Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Axial spondylometaphyseal dysplasia is also caused by NEK1 mutations

(2017) Zheng Wang et al.   JOURNAL OF HUMAN GENETICS

Weighted Protein Interaction Network Analysis of Frontotemporal Dementia

(2017) Raffaele Ferrari et al.   JOURNAL OF PROTEOME RESEARCH

Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways

(2017) Jing Zhong et al.   Cell Death & Disease

LIM kinases: cofilin and beyond

(2017) Chloé Prunier et al.   Oncotarget

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?

(2016) Jean-Marc Taymans et al.   Current Neuropharmacology

Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing

(2016) Brandon E. Aubol et al.   MOLECULAR CELL

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint

(2016) Eleni Petsalaki et al.   Nature Communications

LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation

(2016) Keiko Morimoto et al.   Scientific Reports

NERI: network-medicine based integrative approach for disease gene prioritization by relative importance

(2015) Sérgio N Simões et al.   BMC BIOINFORMATICS

LRRK2 Pathways Leading to Neurodegeneration

(2015) Mark R. Cookson   Current Neurology and Neuroscience Reports

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

(2015) Manoj Amrutkar et al.   FASEB JOURNAL

Cellular processes associated with LRRK2 function and dysfunction

(2015) Rebecca Wallings et al.   FEBS Journal

Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition

(2015) Liu-Xiao Yang et al.   HEPATOLOGY

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

(2015) Mian Zu et al.   MOLECULES

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

(2015) Hiroshi Hanafusa et al.   NATURE CELL BIOLOGY

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology

(2015) Pablo Porras et al.   PROTEOMICS

Computational analysis of the LRRK2 interactome

(2015) Claudia Manzoni et al.   PeerJ

Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains

(2014) Laura Civiero et al.   CHEMISTRY & BIOLOGY

Human CDC2-Like Kinase 1 (CLK1): A Novel Target for Alzheimer’s Disease

(2014) Princi Jain et al.   CURRENT DRUG TARGETS

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

(2014) A. Raquel Esteves et al.   EXPERIMENTAL NEUROLOGY

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

(2014) Lauran Reyniers et al.   JOURNAL OF NEUROCHEMISTRY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Evolutionary Divergence in the Catalytic Activity of the CAM-1, ROR1 and ROR2 Kinase Domains

(2014) Travis W. Bainbridge et al.   PLoS One

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Evaluating DAPK as a therapeutic target

(2013) Yide Huang et al.   APOPTOSIS

DAP-kinase and autophagy

(2013) Vered Levin-Salomon et al.   APOPTOSIS

Regulation of inflammation by DAPK

(2013) Ming-Zong Lai et al.   APOPTOSIS

The DAP-kinase interactome

(2013) Shani Bialik et al.   APOPTOSIS

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway

(2013) C. Kumkhaek et al.   BLOOD

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet

(2013) Emmelie Cansby et al.   FASEB JOURNAL

Aurora kinases in head and neck cancer

(2013) Ranee Mehra et al.   LANCET ONCOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

MASL1: a neglected ROCO protein

(2012) Sybille Dihanich   BIOCHEMICAL SOCIETY TRANSACTIONS

LRRK2 and vesicle trafficking

(2012) Giovanna Sanna et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

(2012) A. Biosa et al.   HUMAN MOLECULAR GENETICS

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium

(2012) Sandra Orchard et al.   NATURE METHODS

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

(2012) Karin Breuer et al.   NUCLEIC ACIDS RESEARCH

Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers

(2012) Laura Civiero et al.   PLoS One

LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

(2012) P. A. Lewis et al.   Science Signaling

Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease

(2012) Byoung Dae Lee et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1

(2012) Joseph D. Jebelli et al.   Scientific Reports

Cyclin-G-associated kinase modifies  -synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study

(2011) A. Dumitriu et al.   HUMAN MOLECULAR GENETICS

PSICQUIC and PSISCORE: accessing and scoring molecular interactions

(2011) Bruno Aranda et al.   NATURE METHODS

MINT, the molecular interaction database: 2012 update

(2011) Luana Licata et al.   NUCLEIC ACIDS RESEARCH

The IntAct molecular interaction database in 2012

(2011) S. Kerrien et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease

(2011) Xianting Li et al.   PLoS One

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor

(2011) Hiroshi Hanafusa et al.   Nature Communications

Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation

(2010) Zdenek Berger et al.   BIOCHEMISTRY

The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization

(2010) B Titz et al.   ONCOGENE

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

(2009) Mar Carmena et al.   CURRENT OPINION IN CELL BIOLOGY

GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression

(2009) H. Shimizu et al.   JOURNAL OF CELL SCIENCE

The WD40 Domain Is Required for LRRK2 Neurotoxicity

(2009) Nathan D. Jorgensen et al.   PLoS One

Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy

(2008) Amir H. DaneshManesh et al.   INTERNATIONAL JOURNAL OF CANCER