Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways

Circulating cell-free DNA indicates M1/M2 responses during septic peritonitis

(2016) Yi Xin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specificity and disease in the ubiquitin system

(2016) V. K. Chaugule et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway

(2016) Ge Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of Sepsis

(2016) Konrad Schmidt et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

E3 ubiquitin ligases as novel targets for inflammatory diseases

(2016) Santosh Kumar Goru et al.   PHARMACOLOGICAL RESEARCH

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

praja2 regulates KSR1 stability and mitogenic signaling

(2016) L Rinaldi et al.   Cell Death & Disease

GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation

(2016) S Ito et al.   Cell Death & Disease

Differential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration

(2016) Chen Yang et al.   Scientific Reports

E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses

(2015) Andrei E. Medvedev et al.   IMMUNOLOGICAL REVIEWS

Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance

(2015) Michael Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

(2015) Nidhi Kapoor et al.   JOURNAL OF IMMUNOLOGY

Overexpression of toll-like receptor 2 in glomerular endothelial cells and podocytes in septic acute kidney injury mouse model

(2015) Yuan Peng et al.   RENAL FAILURE

Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll-like Receptor 2 and Dietary Flavonoid Intake

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MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-κB Signaling Pathway Following Negative Regulation

(2015) Jing Zhong et al.   PLoS One

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

Role of MAPK signal pathways in differentiation process of M2 macrophages induced by high-ambient glucose and TGF-β1

(2014) Ning Su et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

(2014) Feng Xie et al.   Cells

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway

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Cbl-b Is a Critical Regulator of Macrophage Activation Associated With Obesity-Induced Insulin Resistance in Mice

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GTP binding controls complex formation by the human ROCO protein MASL1

(2013) Sybille Dihanich et al.   FEBS Journal

cAMP signalling decreases p300 protein levels by promoting its ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in lung cancer cells

(2013) Min-Jae Jeong et al.   FEBS LETTERS

Ly6 family proteins in neutrophil biology

(2013) Pui Y. Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

(2013) Luca Lignitto et al.   Nature Communications

MASL1: a neglected ROCO protein

(2012) Sybille Dihanich   BIOCHEMICAL SOCIETY TRANSACTIONS

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

HECT and RING finger families of E3 ubiquitin ligases at a glance

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Expression of the Ring Ligase PRAJA2 in Thyroid Cancer

(2012) Silvia Cantara et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

The inflammatory response in sepsis

(2012) Markus Bosmann et al.   TRENDS IN IMMUNOLOGY

Control of PKA stability and signalling by the RING ligase praja2

(2011) Luca Lignitto et al.   NATURE CELL BIOLOGY

Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain

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NF-κB as a central regulator of macrophage function in tumors

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Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity

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The resolution of inflammation: Anti-inflammatory roles for NF-κB

(2009) Toby Lawrence et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NF-κB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes

(2009) Gary Chan et al.   VIRUS RESEARCH