Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

Pinosylvin and Monomethylpinosylvin, Constituents of an Extract from the Knot of Pinus sylvestris, Reduce Inflammatory Gene Expression and Inflammatory Responses in Vivo

(2015) Mirka Laavola et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Why should influenza be a public health priority?

(2015) Ab Osterhaus et al.   VACCINE

Clinical Implications of Antiviral Resistance in Influenza

(2015) Timothy Li et al.   Viruses-Basel

Adamantane-Resistant Influenza A Viruses in the World (1902–2013): Frequency and Distribution of M2 Gene Mutations

(2015) Guoying Dong et al.   PLoS One

N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation

(2014) Brandon E. Aubol et al.   BIOCHEMICAL JOURNAL

Corilagin Protects Against HSV1 Encephalitis Through Inhibiting the TLR2 Signaling Pathways In Vivo and In Vitro

(2014) Yuan-Jin Guo et al.   MOLECULAR NEUROBIOLOGY

Novel Lignan and Stilbenoid Mixture Shows Anticarcinogenic Efficacy in Preclinical PC-3M-luc2 Prostate Cancer Model

(2014) Emrah Yatkin et al.   PLoS One

A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways

(2013) Luoqi Jia et al.   BMC Complementary and Alternative Medicine

A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene

(2013) Jianbo An et al.   JOURNAL OF AUTOIMMUNITY

Inhibitory Effect of the Gallotannin Corilagin on Dextran Sulfate Sodium-Induced Murine Ulcerative Colitis

(2013) Hai-Tao Xiao et al.   JOURNAL OF NATURAL PRODUCTS

Clk/STY (cdc2-Like Kinase 1) and Akt Regulate Alternative Splicing and Adipogenesis in 3T3-L1 Pre-Adipocytes

(2013) Pengfei Li et al.   PLoS One

Library-based Discovery of DYRK1A/CLK1 Inhibitors from Natural Product Extracts

(2012) Patrick Grabher et al.   PLANTA MEDICA

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

(2011) Andrew S. Rosenthal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

(2011) Oleg Fedorov et al.   CHEMISTRY & BIOLOGY

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE