Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

(2017) Gregory M. LaMonte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spread of a single multidrug resistant malaria parasite lineage ( PfPailin ) to Vietnam

(2017) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

Chromosome End Repair and Genome Stability in Plasmodium falciparum

(2017) Susannah F. Calhoun et al.   mBio

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

(2017) Ruda de Luna Almeida Santos et al.   Nature Communications

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

(2017) Celia Miguel-Blanco et al.   Nature Communications

Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome

(2016) Hao-Chi Hsu et al.   BIOCHEMISTRY

Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors

(2016) Pradeep K. Singh et al.   ChemMedChem

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

(2016) Hao Li et al.   NATURE

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

(2016) Shilpi Khare et al.   NATURE

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

(2016) Esilida Sula Karreci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inhibition mechanism of human 20Sproteasomes enables next-generation inhibitor design

(2016) Jil Schrader et al.   SCIENCE

Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum

(2016) James A. Thomas et al.   PLoS One

The novel  2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

(2015) M. Kraus et al.   HAEMATOLOGICA

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Multidrug evolutionary strategies to reverse antibiotic resistance

(2015) M. Baym et al.   SCIENCE

Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914

(2015) Eva M. Huber et al.   STRUCTURE

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

The novel  2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

(2015) M. Kraus et al.   HAEMATOLOGICA

Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

(2014) Hao Li et al.   ACS Chemical Biology

Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome

(2014) Hao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome

(2014) Hao Fan et al.   ACS Medicinal Chemistry Letters

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

(2013) Gang Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis

(2013) Alexander P Gorka et al.   MALARIA JOURNAL

The interplay between drug resistance and fitness in malaria parasites

(2013) Philip J. Rosenthal   MOLECULAR MICROBIOLOGY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Validation of the Proteasome as a Therapeutic Target in Plasmodium Using an Epoxyketone Inhibitor with Parasite-Specific Toxicity

(2012) Hao Li et al.   CHEMISTRY & BIOLOGY

P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

(2012) Laura M. Sanz et al.   PLoS One

Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast

(2011) Makoah N. Aminake et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Proteasome Inhibitor Epoxomicin Has Potent Plasmodium falciparum Gametocytocidal Activity

(2009) B. Czesny et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors selective for mycobacterial versus human proteasomes

(2009) Gang Lin et al.   NATURE

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon

(2008) Andrea Kreidenweiss et al.   MALARIA JOURNAL