The inhibition mechanism of human 20Sproteasomes enables next-generation inhibitor design
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The inhibition mechanism of human 20Sproteasomes enables next-generation inhibitor design
Authors
Keywords
-
Journal
SCIENCE
Volume 353, Issue 6299, Pages 594-598
Publisher
American Association for the Advancement of Science (AAAS)
Online
2016-08-05
DOI
10.1126/science.aaf8993
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ixazomib: First Global Approval
- (2016) Matt Shirley DRUGS
- A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
- (2016) Eva M. Huber et al. Nature Communications
- ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space
- (2015) Ashwin Chari et al. NATURE METHODS
- Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914
- (2015) Eva M. Huber et al. STRUCTURE
- Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib
- (2015) Wayne Harshbarger et al. STRUCTURE
- Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
- (2015) Paula C.A. da Fonseca et al. Nature Communications
- The 26S proteasome is a multifaceted target for anti-cancer therapies
- (2015) Tatyana A. Grigoreva et al. Oncotarget
- Quantum Chemical Studies of Mechanisms for Metalloenzymes
- (2014) Margareta R. A. Blomberg et al. CHEMICAL REVIEWS
- Structural Biology of the Proteasome
- (2013) Erik Kish-Trier et al. Annual Review of Biophysics
- JLigand: a graphical tool for theCCP4 template-restraint library
- (2012) Andrey A. Lebedev et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
- (2012) Eva M. Huber et al. CELL
- Effect of the damping function in dispersion corrected density functional theory
- (2011) Stefan Grimme et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- The ORCA program system
- (2011) Frank Neese Wiley Interdisciplinary Reviews-Computational Molecular Science
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Elucidation of the α-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
- (2010) Melissa Ann Gräwert et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
- (2009) Daniel Finley Annual Review of Biochemistry
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now