Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors

(2016) Pradeep K. Singh et al.   ChemMedChem

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

(2016) Esilida Sula Karreci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inhibition mechanism of human 20Sproteasomes enables next-generation inhibitor design

(2016) Jil Schrader et al.   SCIENCE

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine

(2015) Christian Dubiella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

(2015) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

(2015) Paula C.A. da Fonseca et al.   Nature Communications

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

(2014) Marcelino Arciniega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome

(2014) Hao Fan et al.   ACS Medicinal Chemistry Letters

Optimization of a human IgG B-cell ELISpot assay for the analysis of vaccine-induced B-cell responses

(2013) Maja Jahnmatz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors

(2013) Sevil Ozcan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the Human Proteasome by Imidazoline Scaffolds

(2013) Lauren M. Azevedo et al.   JOURNAL OF MEDICINAL CHEMISTRY

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

(2013) Gang Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noncompetitive Modulation of the Proteasome by Imidazoline Scaffolds Overcomes Bortezomib Resistance and Delays MM Tumor Growth in Vivo

(2012) Theresa A. Lansdell et al.   ACS Chemical Biology

Inhibitors for the Immuno- and Constitutive Proteasome: Current and Future Trends in Drug Development

(2012) Eva Maria Huber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

(2012) K. W. Kalim et al.   JOURNAL OF IMMUNOLOGY

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

(2011) H. Travis Ichikawa et al.   ARTHRITIS AND RHEUMATISM

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome

(2010) Gang Lin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

(2010) Christopher Blackburn et al.   BIOCHEMICAL JOURNAL

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

(2010) Harshani R. Lawrence et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome

(2010) Christopher Blackburn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis

(2010) M. Hirai et al.   BLOOD

Non-Competitive Inhibition by Active Site Binders

(2010) Yuval Blat   Chemical Biology & Drug Design

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

(2009) F. Parlati et al.   BLOOD

Inhibitors selective for mycobacterial versus human proteasomes

(2009) Gang Lin et al.   NATURE

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Distinct Specificities ofMycobacterium tuberculosisand Mammalian Proteasomes forN-Acetyl Tripeptide Substrates

(2008) Gang Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE