Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

(2016) Izidor Sosič et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine

(2015) Christian Dubiella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities

(2015) Gerjan de Bruin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Treatment of chronic graft-versus-host disease with bortezomib

(2014) C.-C. S. Pai et al.   BLOOD

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome

(2014) Hao Fan et al.   ACS Medicinal Chemistry Letters

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

(2013) Gang Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors for the Immuno- and Constitutive Proteasome: Current and Future Trends in Drug Development

(2012) Eva Maria Huber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Hydroxyureas as Noncovalent Proteasome Inhibitors

(2011) Nerea Gallastegui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

Successful use of bortezomib in a patient with systemic lupus erythematosus and multiple myeloma

(2010) K. Frohlich et al.   ANNALS OF THE RHEUMATIC DISEASES

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

(2010) Christopher Blackburn et al.   BIOCHEMICAL JOURNAL

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome

(2010) Christopher Blackburn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Inhibitors selective for mycobacterial versus human proteasomes

(2009) Gang Lin et al.   NATURE

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE