Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Drugging RAS: Know the enemy

(2017) Bjoern Papke et al.   SCIENCE

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells

(2017) Timothy D. Martin et al.   Cell Reports

Deconstruction of the Ras switching cycle through saturation mutagenesis

(2017) Pradeep Bandaru et al.   eLife

Progress in Top-Down Proteomics and the Analysis of Proteoforms

(2016) Timothy K. Toby et al.   Annual Review of Analytical Chemistry

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

(2016) Luca Fornelli et al.   JOURNAL OF PROTEOME RESEARCH

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry

(2016) Lissa C. Anderson et al.   JOURNAL OF PROTEOME RESEARCH

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

(2016) Josiah E. Hutton et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

(2016) Srisathiyanarayanan Dharmaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras activation revisited: role of GEF and GAP systems

(2015) Anne Hennig et al.   BIOLOGICAL CHEMISTRY

A New View of Ras Isoforms in Cancers

(2015) R. Nussinov et al.   CANCER RESEARCH

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

(2015) A. D. Cox et al.   CLINICAL CANCER RESEARCH

Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations

(2015) Dean E. Hammond et al.   JOURNAL OF PROTEOME RESEARCH

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

(2015) J. C. Hunter et al.   MOLECULAR CANCER RESEARCH

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

(2015) Frederick D. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

(2015) William K. Gillette et al.   Scientific Reports

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High-performance Quadrupole and an Ultra-high-field Orbitrap Analyzer

(2014) Richard Alexander Scheltema et al.   MOLECULAR & CELLULAR PROTEOMICS

CPTAC Assay Portal: a repository of targeted proteomic assays

(2014) Jeffrey R Whiteaker et al.   NATURE METHODS

Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair

(2013) P. J. Halvey et al.   CANCER RESEARCH

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

The emergence of top-down proteomics in clinical research

(2013) John P Savaryn et al.   Genome Medicine

Liquid Chromatographic Analysis and Mass Spectrometric Identification of Farnesylated Peptides

(2012) Marina Wotske et al.   ANALYTICAL CHEMISTRY

Glutathiolated Ras: Characterization and implications for Ras activation

(2012) G. Aaron Hobbs et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of RAS oncogenicity by acetylation

(2012) M. H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling

(2012) Amy Young et al.   Cancer Discovery

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

Mutant proteins as cancer-specific biomarkers

(2011) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome

(2008) Jinru Shia   JOURNAL OF MOLECULAR DIAGNOSTICS