Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer’s disease

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

Intrinsically disordered proteins: emerging interaction specialists

(2015) Peter Tompa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shedding light on prion disease

(2015) Markus Glatzel et al.   Prion

ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders

(2015) Mauricio Torres et al.   VIRUS RESEARCH

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease

(2014) Frank Dohler et al.   BRAIN

Aβ induces its own prion protein N-terminal fragment (PrPN1)–mediated neutralization in amorphous aggregates

(2014) Maxime Béland et al.   NEUROBIOLOGY OF AGING

The prion protein is critical for DNA repair and cell survival after genotoxic stress

(2014) Anne Bravard et al.   NUCLEIC ACIDS RESEARCH

Behavioral abnormalities in prion protein knockout mice and the potential relevance of PrPCfor the cytoskeleton

(2014) Matthias Schmitz et al.   Prion

PrP overdrive

(2014) Alex J McDonald et al.   Prion

Endoproteolytic processing of the mammalian prion glycoprotein family

(2013) Charles E. Mays et al.   FEBS Journal

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration

(2013) Hermann C. Altmeppen et al.   FEBS Journal

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PrPC Homodimerization Stimulates the Production of PrPC Cleaved Fragments PrPN1 and PrPC1

(2012) M. Beland et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hsp70 binds to PrPCin the process of PrPCrelease via exosomes from THP-1 monocytes

(2010) Gui‑hua Wang et al.   CELL BIOLOGY INTERNATIONAL

Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers

(2009) Haakon B. Nygaard et al.   ARCHIVES OF NEUROLOGY

Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

(2009) Oishee Chakrabarti et al.   CELL

α-Helical Domains Promote Translocation of Intrinsically Disordered Polypeptides into the Endoplasmic Reticulum

(2009) Margit Miesbauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer

(2009) Chaoyang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

The Comprehensive Native Interactome of a Fully Functional Tagged Prion Protein

(2009) Dorothea Rutishauser et al.   PLoS One

Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

(2009) Joel C. Watts et al.   PLoS Pathogens

Stress-protective signalling of prion protein is corrupted by scrapie prions

(2008) Angelika S Rambold et al.   EMBO JOURNAL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Pathologic Prion Protein Infects Cells by Lipid-Raft Dependent Macropinocytosis

(2008) Jehangir S. Wadia et al.   PLoS One