Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration

Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10

(2012) Johannes Prox et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Targeting the cellular prion protein to treat neurodegeneration

(2012) Emiliano Biasini et al.   Future Medicinal Chemistry

Cellular Prion Protein Regulates Its Own α-Cleavage through ADAM8 in Skeletal Muscle

(2012) Jingjing Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity

(2012) Krzysztof Nieznanski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Protease-sensitive prion species in neoplastic spleens of prion-infected mice with uncoupling of PrPSc and prion infectivity

(2012) S. Krasemann et al.   JOURNAL OF GENERAL VIROLOGY

PrPC Homodimerization Stimulates the Production of PrPC Cleaved Fragments PrPN1 and PrPC1

(2012) M. Beland et al.   JOURNAL OF NEUROSCIENCE

The N-Terminal, Polybasic Region of PrPC Dictates the Efficiency of Prion Propagation by Binding to PrPSc

(2012) J. A. Turnbaugh et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

(2012) X.-Z. Wan et al.   JOURNAL OF NEUROSCIENCE

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Separate mechanisms act concurrently to shed and release the prion protein from the cell

(2012) Lotta Wik et al.   Prion

Regulation of amyloid-β production by the prion protein

(2012) Heledd H. Griffiths et al.   Prion

α-Cleavage of cellular prion protein

(2012) Jingjing Liang et al.   Prion

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PrP Antibodies Do Not Trigger Mouse Hippocampal Neuron Apoptosis

(2012) P.-C. Klohn et al.   SCIENCE

Release of Full-Length PrPC from Cultured Neurons Following Neurotoxic Challenges

(2012) Kevin K. W. Wang et al.   Frontiers in Neurology

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Cellular prion protein is essential for oligomeric amyloid- -induced neuronal cell death

(2011) W. Kudo et al.   HUMAN MOLECULAR GENETICS

Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein

(2011) Heledd H. Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

(2011) Marcia L. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Secretase-derived Fragment of Cellular Prion, N1, Protects against Monomeric and Oligomeric Amyloid β (Aβ)-associated Cell Death

(2011) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

(2011) Clive Bate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Naturally Occurring C-terminal Fragment of the Prion Protein (PrP) Delays Disease and Acts as a Dominant-negative Inhibitor of PrPScFormation

(2011) Laura Westergard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

(2011) Fabiana A. Caetano et al.   JOURNAL OF NEUROCHEMISTRY

A  Inhibition of Ionic Conductance in Mouse Basal Forebrain Neurons Is Dependent upon the Cellular Prion Protein PrPC

(2011) K. Alier et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

(2011) Hermann C Altmeppen et al.   Molecular Neurodegeneration

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

N-Glycans and Glycosylphosphatidylinositol-Anchor Act on Polarized Sorting of Mouse PrPC in Madin-Darby Canine Kidney Cells

(2011) Berta Puig et al.   PLoS One

Prion protein at the crossroads of physiology and disease

(2011) Emiliano Biasini et al.   TRENDS IN NEUROSCIENCES

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

(2011) Johannes Prox et al.   EXPERIMENTAL BRAIN RESEARCH

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse

(2010) Erika Chung et al.   BMC NEUROSCIENCE

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Endogenous Proteolytic Cleavage of Disease-associated Prion Protein to Produce C2 Fragments Is Strongly Cell- and Tissue-dependent

(2010) Michel Dron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis elegans

(2010) N. Bizat et al.   JOURNAL OF NEUROSCIENCE

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unexpected Tolerance of α-Cleavage of the Prion Protein to Sequence Variations

(2010) José B. Oliveira-Martins et al.   PLoS One

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatal Transmissible Amyloid Encephalopathy: A New Type of Prion Disease Associated with Lack of Prion Protein Membrane Anchoring

(2010) Bruce Chesebro et al.   PLoS Pathogens

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein

(2009) David R. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The α-Secretase-derived N-terminal Product of Cellular Prion, N1, Displays Neuroprotective Functionin Vitroandin Vivo

(2009) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Proportions of C1 Truncated Prion Protein Protect Against Cellular M1000 Prion Infection

(2009) Victoria Lewis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo

(2009) Kristina Endres et al.   NEUROBIOLOGY OF DISEASE

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

Stress-protective signalling of prion protein is corrupted by scrapie prions

(2008) Angelika S Rambold et al.   EMBO JOURNAL

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Novel Sorting Nexin SNX33 Interferes with Cellular PrPScFormation by Modulation of PrPcShedding

(2008) Andreas Heiseke et al.   TRAFFIC