Shedding light on prion disease

The sheddase ADAM10 is a potent modulator of prion disease

(2015) Hermann C Altmeppen et al.   eLife

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease

(2014) Frank Dohler et al.   BRAIN

Axonal and Transynaptic Spread of Prions

(2014) H. Shearin et al.   JOURNAL OF VIROLOGY

The GPI-anchoring of PrP

(2014) Berta Puig et al.   Prion

Evidence That Bank Vole PrP Is a Universal Acceptor for Prions

(2014) Joel C. Watts et al.   PLoS Pathogens

Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein

(2014) Alejandra Rangel et al.   Acta Neuropathologica Communications

Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence

(2013) Michael S. Wolin   BIOCHEMICAL JOURNAL

The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers

(2013) Nadine D. Younan et al.   FASEB JOURNAL

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration

(2013) Hermann C. Altmeppen et al.   FEBS Journal

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Paradigm for Enzymatic Control of α-Cleavage and β-Cleavage of the Prion Protein

(2013) Alex J. McDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

ADAM10 in Synaptic Physiology and Pathology

(2013) Stefano Musardo et al.   Neurodegenerative Diseases

Human prion diseases: Molecular, cellular and population biology

(2013) Mark W. Head   NEUROPATHOLOGY

Elucidating the role of cofactors in mammalian prion propagation

(2013) Surachai Supattapone   Prion

Recombinant Human Prion Protein Inhibits Prion Propagation in vitro

(2013) Jue Yuan et al.   Scientific Reports

Chronic Wasting Disease in Bank Voles: Characterisation of the Shortest Incubation Time Model for Prion Diseases

(2013) Michele Angelo Di Bari et al.   PLoS Pathogens

Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein

(2013) Alejandra Rangel et al.   Acta Neuropathologica Communications

Persistent retroviral infection with MoMuLV influences neuropathological signature and phenotype of prion disease

(2012) Susanne Krasemann et al.   ACTA NEUROPATHOLOGICA

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity

(2012) Krzysztof Nieznanski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-sensitive prion species in neoplastic spleens of prion-infected mice with uncoupling of PrPSc and prion infectivity

(2012) S. Krasemann et al.   JOURNAL OF GENERAL VIROLOGY

PrPC Homodimerization Stimulates the Production of PrPC Cleaved Fragments PrPN1 and PrPC1

(2012) M. Beland et al.   JOURNAL OF NEUROSCIENCE

The N-Terminal, Polybasic Region of PrPC Dictates the Efficiency of Prion Propagation by Binding to PrPSc

(2012) J. A. Turnbaugh et al.   JOURNAL OF NEUROSCIENCE

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity

(2012) Victoria Lewis et al.   Molecular Neurodegeneration

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Ion channels induced by the prion protein

(2012) Isaac H. Solomon et al.   Prion

α-Cleavage of cellular prion protein

(2012) Jingjing Liang et al.   Prion

Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

(2011) Marcia L. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Secretase-derived Fragment of Cellular Prion, N1, Protects against Monomeric and Oligomeric Amyloid β (Aβ)-associated Cell Death

(2011) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Naturally Occurring C-terminal Fragment of the Prion Protein (PrP) Delays Disease and Acts as a Dominant-negative Inhibitor of PrPScFormation

(2011) Laura Westergard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

(2011) Hermann C Altmeppen et al.   Molecular Neurodegeneration

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions

(2011) M. Klingeborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous generation of anchorless prions in transgenic mice

(2011) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion protein at the crossroads of physiology and disease

(2011) Emiliano Biasini et al.   TRENDS IN NEUROSCIENCES

An overview of animal prion diseases

(2011) Muhammad Imran et al.   Virology Journal

Rapid cell-surface prion protein conversion revealed using a novel cell system

(2011) R. Goold et al.   Nature Communications

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection

(2010) M. Klingeborn et al.   JOURNAL OF VIROLOGY

Compartment-Restricted Biotinylation Reveals Novel Features of Prion Protein Metabolism in Vivo

(2010) Amy B. Emerman et al.   MOLECULAR BIOLOGY OF THE CELL

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

The role of the prion protein membrane anchor in prion infection

(2010) Suzette A. Priola et al.   Prion

Tunnelling nanotubes

(2010) Karine Gousset et al.   Prion

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Fatal Transmissible Amyloid Encephalopathy: A New Type of Prion Disease Associated with Lack of Prion Protein Membrane Anchoring

(2010) Bruce Chesebro et al.   PLoS Pathogens

The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro

(2009) Jae-Il Kim et al.   FEBS LETTERS

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein

(2009) David R. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The α-Secretase-derived N-terminal Product of Cellular Prion, N1, Displays Neuroprotective Functionin Vitroandin Vivo

(2009) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cells Expressing Anchorless Prion Protein Are Resistant to Scrapie Infection

(2009) K. L. McNally et al.   JOURNAL OF VIROLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo

(2009) Kristina Endres et al.   NEUROBIOLOGY OF DISEASE

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

De Novo Generation of Infectious Prions In Vitro Produces a New Disease Phenotype

(2009) Marcelo A. Barria et al.   PLoS Pathogens

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

(2008) Sandrine Alais et al.   BIOLOGY OF THE CELL

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS