Automated analysis of cell migration and nuclear envelope rupture in confined environments

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability?

(2017) Pragya Shah et al.   TRENDS IN CELL BIOLOGY

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

(2017) Tohru Takaki et al.   Nature Communications

Consequences of a tight squeeze: Nuclear envelope rupture and repair

(2017) Philipp Isermann et al.   Nucleus

Consequences of a tight squeeze: Nuclear envelope rupture and repair

(2017) Philipp Isermann et al.   Nucleus

RETRACTED: FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis

(2016) Colleen T. Skau et al.   CELL

Nuclear Lamins in Cancer

(2016) Jerome Irianto et al.   Cellular and Molecular Bioengineering

Squish and squeeze — the nucleus as a physical barrier during migration in confined environments

(2016) Alexandra Lynn McGregor et al.   CURRENT OPINION IN CELL BIOLOGY

Causes and consequences of nuclear envelope alterations in tumour progression

(2016) Emily S. Bell et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Nuclear envelope rupture drives genome instability in cancer

(2016) Sanghee Lim et al.   MOLECULAR BIOLOGY OF THE CELL

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells

(2016) J. Robijns et al.   Scientific Reports

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

(2015) Lena A. Lautscham et al.   BIOPHYSICAL JOURNAL

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments

(2015) Patricia M. Davidson et al.   Integrative Biology

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion

(2015) Dustin G. Thomas et al.   JOURNAL OF CELL BIOLOGY

An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments

(2015) Majid Malboubi et al.   MICROELECTRONIC ENGINEERING

Cancer cell migration in 3D tissue: Negotiating space by proteolysis and nuclear deformability

(2015) Marina Krause et al.   Cell Adhesion & Migration

Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer

(2015) Ayaka Matsumoto et al.   Cancer Medicine

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling

(2013) Monika Zwerger et al.   HUMAN MOLECULAR GENETICS

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Nuclear deformation during breast cancer cell transmigration

(2012) Yi Fu et al.   LAB ON A CHIP

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer

(2011) Callinice D. Capo-chichi et al.   Chinese Journal of Cancer

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY