Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia

(2017) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

Unacylated ghrelin normalizes skeletal muscle oxidative stress and prevents muscle catabolism by enhancing tissue mitophagy in experimental chronic kidney disease

(2017) Gianluca Gortan Cappellari et al.   FASEB JOURNAL

Exercise training decreases NADPH oxidase activity and restores skeletal muscle mass in heart failure rats

(2017) Telma F. Cunha et al.   JOURNAL OF APPLIED PHYSIOLOGY

Epigenetic regulation of muscle development

(2017) Esther Barreiro et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Epigenetics of cancer-associated muscle catabolism

(2017) Ryan M Carr et al.   Epigenomics

Redox homeostasis and age-related deficits in neuromuscular integrity and function

(2017) Giorgos K. Sakellariou et al.   Journal of Cachexia Sarcopenia and Muscle

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

(2016) Johanna Abrigo et al.   CELLULAR SIGNALLING

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

Redox regulation of autophagy in skeletal muscle

(2016) George G. Rodney et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox control of skeletal muscle atrophy

(2016) Scott K. Powers et al.   FREE RADICAL BIOLOGY AND MEDICINE

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles

(2016) Rosalind F. Roberts et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

(2016) Johanna Abrigo et al.   Oxidative Medicine and Cellular Longevity

The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting

(2016) James A. Carson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

(2016) Eva Pigna et al.   Scientific Reports

Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities

(2015) Nashwa Cheema et al.   AGING CELL

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

(2015) Jon Sin et al.   Autophagy

Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

(2015) Martina Chrisam et al.   Autophagy

Mitochondrial quality control pathways as determinants of metabolic health

(2015) Ntsiki M. Held et al.   BIOESSAYS

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-MediatedMuRF1ExpressionNovelty and Significance

(2015) Philipp Du Bois et al.   CIRCULATION RESEARCH

Increased neuromuscular transmission instability and motor unit remodelling with diabetic neuropathy as assessed using novel near fibre motor unit potential parameters

(2015) Matti D. Allen et al.   CLINICAL NEUROPHYSIOLOGY

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

(2015) Tomoyasu Kadoguchi et al.   EXPERIMENTAL PHYSIOLOGY

Skeletal Muscle Abnormalities in Heart Failure

(2015) Shintaro Kinugawa et al.   International Heart Journal

Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle

(2015) Pearl Lin Tan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

(2015) Claudio Cabello-Verrugio et al.   MEDICINAL RESEARCH REVIEWS

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Xanthine Oxidase: Isolation, Assays of Activity, and Inhibition

(2015) Danijela A. Kostić et al.   Journal of Chemistry

Uremic myopathy: is oxidative stress implicated in muscle dysfunction in uremia?

(2015) Antonia Kaltsatou et al.   Frontiers in Physiology

The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function

(2015) Philip A. Kramer et al.   Frontiers in Physiology

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

Measurement and Characterization of Superoxide Generation from Xanthine Dehydrogenase: A Redox-Regulated Pathway of Radical Generation in Ischemic Tissues

(2014) Masaichi-Chang-il Lee et al.   BIOCHEMISTRY

Effects of allopurinol on exercise-induced muscle damage: new therapeutic approaches?

(2014) F. Sanchis-Gomar et al.   CELL STRESS & CHAPERONES

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

(2014) Daniel T. Shaughnessy et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Isoorientin Induces Apoptosis and Autophagy Simultaneously by Reactive Oxygen Species (ROS)-Related p53, PI3K/Akt, JNK, and p38 Signaling Pathways in HepG2 Cancer Cells

(2014) Li Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Muscle disuse alters skeletal muscle contractile function at the molecular and cellular levels in older adult humans in a sex-specific manner

(2014) Damien M. Callahan et al.   JOURNAL OF PHYSIOLOGY-LONDON

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

(2014) Carla Meneses et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014

(2014) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases

(2014) Atsuko Nakanishi   Aging and Disease

Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans

(2014) Mark S. Miller et al.   Frontiers in Physiology

Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways

(2014) Naomi E. Brooks et al.   Frontiers in Physiology

Autophagy in Locomotor Muscles of Patients with Chronic Obstructive Pulmonary Disease

(2013) Yeting Guo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reactive Oxygen Species Regulation of Autophagy in Skeletal Muscles

(2013) Mashrur Rahman et al.   ANTIOXIDANTS & REDOX SIGNALING

Heart Failure-Induced Cachexia

(2013) Marina Politi Okoshi et al.   Arquivos Brasileiros de Cardiologia

Disuse-induced muscle wasting

(2013) Sue C. Bodine   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

(2013) Marco Sandri   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant

(2013) Erin E. Talbert et al.   JOURNAL OF APPLIED PHYSIOLOGY

Natural Compounds as Modulators of NADPH Oxidases

(2013) Tullia Maraldi   Oxidative Medicine and Cellular Longevity

NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging Concepts

(2012) Sanja Coso et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure–function relationships in calpains

(2012) Robert L. Campbell et al.   BIOCHEMICAL JOURNAL

Angiotensin II: Role in Skeletal Muscle Atrophy

(2012) Claudio Cabello-Verrugio et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia

(2012) Jochen Springer et al.   INTERNATIONAL JOURNAL OF CANCER

Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle

(2012) Sharon L. Rowan et al.   PLoS One

Angiotensin II Infusion Induces Marked Diaphragmatic Skeletal Muscle Atrophy

(2012) Bashir M. Rezk et al.   PLoS One

Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases

(2012) Frederic Derbre et al.   PLoS One

Molecular and cellular mechanisms of skeletal muscle atrophy: an update

(2012) Alessandro Fanzani et al.   Journal of Cachexia Sarcopenia and Muscle

Angiotensin II, Oxidative Stress and Skeletal Muscle Wasting

(2011) Sergiy Sukhanov et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Mitophagy: A Complex Mechanism of Mitochondrial Removal

(2011) Ivana Novak   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent

(2011) Laura C. Semprun-Prieto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myostatin induces autophagy in skeletal muscle in vitro

(2011) Jen Y. Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways

(2011) Wen-Jun Duan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice

(2011) Michael J. Ryan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

(2011) Sue Goo Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis and myostatin mRNA are upregulated in the skeletal muscle of patients with chronic kidney disease

(2011) Daniela Verzola et al.   KIDNEY INTERNATIONAL

Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis

(2011) Christopher L. Mendias et al.   MUSCLE & NERVE

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species

(2011) R. Wani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xanthine Oxidase and Uric Acid in Cardiovascular Disease: Clinical Impact and Therapeutic Options

(2011) Wolfram Doehner et al.   SEMINARS IN NEPHROLOGY

Wasting in chronic kidney disease

(2011) Robert H. Mak et al.   Journal of Cachexia Sarcopenia and Muscle

Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle

(2011) Melanie J. Sullivan-Gunn et al.   Journal of Cachexia Sarcopenia and Muscle

Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model

(2010) Balindiwe Sishi et al.   EXPERIMENTAL PHYSIOLOGY

Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways

(2010) Alexander Doyle et al.   FASEB JOURNAL

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

Oxidation enhances myofibrillar protein degradation via calpain and caspase-3

(2010) Ashley J. Smuder et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

(2010) Melissa A. Whidden et al.   JOURNAL OF APPLIED PHYSIOLOGY

TNF-α Induces Macroautophagy and Regulates MHC Class II Expression in Human Skeletal Muscle Cells

(2010) Christian W. Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

(2009) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Attenuation of skeletal muscle atrophy in cancer cachexia by d-myo-inositol 1,2,6-triphosphate

(2009) S. T. Russell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Up-regulation of calcium-dependent proteolysis in human myoblasts under acute oxidative stress

(2009) Elise Dargelos et al.   EXPERIMENTAL CELL RESEARCH

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen peroxide is the major oxidant product of xanthine oxidase

(2009) Eric E. Kelley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apoptotic signaling induced by H2O2-mediated oxidative stress in differentiated C2C12 myotubes

(2009) Parco M. Siu et al.   LIFE SCIENCES

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

(2009) Nava Bashan et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Cancer cachexia: medical management

(2009) Giovanni Mantovani et al.   SUPPORTIVE CARE IN CANCER

Calpain-1 is required for hydrogen peroxide-induced myotube atrophy

(2008) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells

(2008) Isabella Irrcher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-κB activation and expression

(2008) Bruce C. Frier et al.   CELL STRESS & CHAPERONES

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

(2008) John Papaconstantinou   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

(2008) Scott K. Powers et al.   PHYSIOLOGICAL REVIEWS

Calcium-dependent proteolytic system and muscle dysfunctions: A possible role of calpains in sarcopenia

(2007) E. Dargelos et al.   BIOCHIMIE

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise

(2007) Richard A. Dennis et al.   PHYSIOLOGICAL GENOMICS