A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

The Monocyte in Atherosclerosis — Should I Stay or Should I Go Now?

(2012) Robert E. Gerszten et al.   NEW ENGLAND JOURNAL OF MEDICINE

A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP

(2012) James S. Wiley et al.   Purinergic Signalling

P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers

(2011) LS Antonio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acceleration of disulfide-coupled protein folding using glutathione derivatives

(2011) Masaki Okumura et al.   FEBS Journal

A Loss-of-Function Polymorphism in the Human P2X4 Receptor Is Associated With Increased Pulse Pressure

(2011) Leanne Stokes et al.   HYPERTENSION

P2X7 Is a Scavenger Receptor for Apoptotic Cells in the Absence of Its Ligand, Extracellular ATP

(2011) B. J. Gu et al.   JOURNAL OF IMMUNOLOGY

Age related macular degeneration and drusen: Neuroinflammation in the retina

(2011) Elisa Buschini et al.   PROGRESS IN NEUROBIOLOGY

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

The human P2X7 receptor and its role in innate immunity

(2011) J. S. Wiley et al.   TISSUE ANTIGENS

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Extracellular ATP dissociates nonmuscle myosin from P2X7 complex: this dissociation regulates P2X7 pore formation

(2009) Ben J. Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration

(2009) Anand Swaroop et al.   Annual Review of Genomics and Human Genetics

The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP

(2009) B. J. Gu et al.   BLOOD

New era for personalized medicine: the diagnosis and management of age-related macular degeneration

(2009) Paul N Baird et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Genetics of age-related macular degeneration

(2009) Andrew YC Ting et al.   CURRENT OPINION IN OPHTHALMOLOGY

Dynamic regulation of the P2X4receptor in alveolar macrophages by phagocytosis and classical activation

(2009) Leanne Stokes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents

(2009) Theresa Puthussery et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Modulation of an Active-Site Cysteine pKa Allows PDI to Act as a Catalyst of both Disulfide Bond Formation and Isomerization

(2009) Anna-Riikka Karala et al.   JOURNAL OF MOLECULAR BIOLOGY

Delayed P2X4R expression after hypoxia–ischemia is associated with microglia in the immature rat brain

(2009) Julie A. Wixey et al.   JOURNAL OF NEUROIMMUNOLOGY

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

P2X receptors: dawn of the post-structure era

(2009) Mark T. Young   TRENDS IN BIOCHEMICAL SCIENCES

Age-Related Macular Degeneration

(2008) Rama D. Jager et al.   NEW ENGLAND JOURNAL OF MEDICINE