The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions

Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein–protein interactions of 14-3-3

(2017) Alwin M. Hartman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase–dependent mechanism

(2017) Cen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3ζ binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors

(2017) Y Gu et al.   LEUKEMIA

Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration

(2017) Courtney J. Banks et al.   MOLECULAR AND CELLULAR BIOLOGY

When the guardian sleeps: Reactivation of the p53 pathway in cancer

(2017) Olaf Merkel et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression

(2017) Z Teo et al.   ONCOGENE

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

(2017) Nikolai N. Sluchanko et al.   STRUCTURE

New insights into stem cells

(2017) Q Zhou   Journal of Molecular Cell Biology

Identification of a redox-modulatory interaction between selenoprotein W and 14-3-3 protein

(2016) Yeong Ha Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

(2016) Qiaoli Chen et al.   DIABETOLOGIA

The role of the 14-3-3 protein family in health, disease, and drug development

(2016) Yasaman Aghazadeh et al.   DRUG DISCOVERY TODAY

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)

(2016) Olivia Petrvalska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteome-wide Structural Analysis of PTM Hotspots Reveals Regulatory Elements Predicted to Impact Biological Function and Disease

(2016) Matthew P. Torres et al.   MOLECULAR & CELLULAR PROTEOMICS

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

(2016) Simone M. Schoenwaelder et al.   Nature Communications

Oncogenic regulation of tumor metabolic reprogramming

(2016) Míriam Tarrado-Castellarnau et al.   Oncotarget

14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2

(2015) Jia Xu et al.   CANCER CELL

Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities

(2015) Abigael Cheruiyot et al.   DNA REPAIR

14-3-3 Proteins Restrain the Exo1 Nuclease to Prevent Overresection

(2015) Xiaoqing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase 6 (HDAC6) Promotes the Pro-survival Activity of 14-3-3ζ via Deacetylation of Lysines within the 14-3-3ζ Binding Pocket

(2015) Jeffrey B. Mortenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of PTM Hotspots (SAPH-ire) – A Quantitative Informatics Method Enabling the Discovery of Novel Regulatory Elements in Protein Families

(2015) Henry M. Dewhurst et al.   MOLECULAR & CELLULAR PROTEOMICS

Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins

(2015) Sunny Rae Slone et al.   NEUROBIOLOGY OF DISEASE

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

(2014) Qiaoli Chen et al.   CELLULAR SIGNALLING

Small Molecule Modulators of Protein–Protein Interactions: Selected Case Studies

(2014) Madhu Aeluri et al.   CHEMICAL REVIEWS

Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

(2014) Mattia Mori et al.   ChemMedChem

Effects of Physical Exercise on the P38MAPK/REDD1/14-3-3 Pathways in the Myocardium of Diet-Induced Obesity Rats

(2014) B. Pieri et al.   HORMONE AND METABOLIC RESEARCH

Protein Modifications Regulate the Role of 14-3-3γ Adaptor Protein in cAMP-induced Steroidogenesis in MA-10 Leydig Cells

(2014) Yasaman Aghazadeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOD2 to SOD1 Switch in Breast Cancer

(2014) Luena Papa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

dbSNO 2.0: a resource for exploring structural environment, functional and disease association and regulatory network of protein S-nitrosylation

(2014) Yi-Ju Chen et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W

(2013) Yeong Ha Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

14-3-3  Orchestrates Mammary Tumor Onset and Progression via miR-221-Mediated Cell Proliferation

(2013) S. K. Rehman et al.   CANCER RESEARCH

Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions

(2013) Philipp Thiel et al.   CHEMICAL COMMUNICATIONS

Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3

(2013) Kenji Takeda et al.   GENES TO CELLS

Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation

(2013) Sabine S. Neukamm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

(2013) G. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-I B Kinase Cascade

(2013) M. C. Puckett et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system

(2013) Ben C Collins et al.   NATURE METHODS

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

(2013) Jun Tang et al.   PLoS One

Monomeric 14-3-3ζ Has a Chaperone-Like Activity and Is Stabilized by Phosphorylated HspB6

(2012) Nikolai N. Sluchanko et al.   BIOCHEMISTRY

Small-molecule modulators of 14-3-3 protein–protein interactions

(2012) Christian Ottmann   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis

(2012) Yong-Ming Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

(2012) Sofie Dabros Andersen et al.   DNA REPAIR

14-3-3 zeta as novel molecular target for cancer therapy

(2012) Ajay Matta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein

(2012) Jun-Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Binding of the Phosphorylated S233- and S259-Binding Sites of C-RAF to One 14-3-3ζ Dimer

(2012) Manuela Molzan et al.   JOURNAL OF MOLECULAR BIOLOGY

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

(2011) Markus Bach et al.   BIOCHEMICAL JOURNAL

Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case

(2011) Valentina Corradi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting 14-3-3zeta in cancer therapy

(2011) X Yang et al.   CANCER GENE THERAPY

HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia

(2011) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration

(2011) Hiroki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Biotin Switch-Based Proteomics Approach Identifies 14-3-3ζ as a Target of Sirt1 in the Metabolic Regulation of Caspase-2

(2011) Joshua L. Andersen et al.   MOLECULAR CELL

14-3-3Zeta Positive Expression is Associated With a Poor Prognosis in Patients With Glioblastoma

(2011) Xiaoliang Yang et al.   NEUROSURGERY

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit

(2011) C L Neal et al.   ONCOGENE

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

(2011) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modification of 14-3-3 isoforms and regulation of cellular function

(2011) Alastair Aitken   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis

(2011) Alexandra K. Gardino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

14-3-3 proteins as potential therapeutic targets

(2011) Jing Zhao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

(2011) Shuai Chen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

(2010) François B. Favier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Phosphomimicking mutations of human 14-3-3ζ affect its interaction with tau protein and small heat shock protein HspB6

(2010) Nikolai N. Sluchanko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bioinformatic and experimental survey of 14-3-3-binding sites

(2010) Catherine Johnson et al.   BIOCHEMICAL JOURNAL

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

(2010) Silvia Vega-Rubin-de-Celis et al.   BIOCHEMISTRY

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

(2010) Valentina Corradi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function

(2010) Joanna M. Woodcock et al.   CELLULAR SIGNALLING

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

(2010) B. C. Litzenburger et al.   CLINICAL CANCER RESEARCH

14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

(2010) Kousuke Kasahara et al.   EMBO JOURNAL

14-3-3ζ as a prognostic marker and therapeutic target for cancer

(2010) Christopher L Neal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c

(2010) Takeshi Kanno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

14-3-3 Epsilon Dynamically Interacts with Key Components of Mitogen-Activated Protein Kinase Signal Module for Selective Modulation of the TNF-α-Induced Time Course-Dependent NF-κB Activity

(2010) Shuai Zuo et al.   JOURNAL OF PROTEOME RESEARCH

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

(2010) Yang Li et al.   NATURE MEDICINE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

(2009) Christian Pehmøller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice

(2009) Weidong Cao et al.   APOPTOSIS

Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells

(2009) Jianrui Song et al.   Autophagy

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

14-3-3ζ Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

(2009) Jing Lu et al.   CANCER CELL

14-3-3  Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival

(2009) C. L. Neal et al.   CANCER RESEARCH

Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2

(2009) Leta K. Nutt et al.   DEVELOPMENTAL CELL

Copy number gain and oncogenic activity of YWHAZ/14-3-3ζ in head and neck squamous cell carcinoma

(2009) Mauting Lin et al.   INTERNATIONAL JOURNAL OF CANCER

14-3-3ζ Mediates Resistance of Diffuse Large B Cell Lymphoma to an Anthracycline-based Chemotherapeutic Regimen

(2009) Steve A. Maxwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation

(2009) Hyun-A Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential 14-3-3 Affinity Capture Reveals New Downstream Targets of Phosphatidylinositol 3-Kinase Signaling

(2009) Fanny Dubois et al.   MOLECULAR & CELLULAR PROTEOMICS

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome

(2009) L M Cockrell et al.   ONCOGENE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Effect of mutations mimicking phosphorylation on the structure and properties of human 14-3-3ζ

(2008) Nikolai N. Sluchanko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulating the Motor for GLUT4 Vesicle Traffic

(2008) Geoffrey D. Holman et al.   Cell Metabolism

CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes

(2008) Ming Fai Yip et al.   Cell Metabolism

14-3-3  Modulates Pancreatic Cancer Cell Survival and Invasiveness

(2008) D. Neupane et al.   CLINICAL CANCER RESEARCH

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

(2008) S. Rajagopalan et al.   NUCLEIC ACIDS RESEARCH

Non-functional phosphorylations?

(2008) Gustav E. Lienhard   TRENDS IN BIOCHEMICAL SCIENCES