Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions

A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface

(2013) Carolin Anders et al.   CHEMISTRY & BIOLOGY

Molecular tweezers modulate 14-3-3 protein–protein interactions

(2013) David Bier et al.   Nature Chemistry

Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

(2012) Philipp Thiel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Structure-based prediction of protein–protein interactions on a genome-wide scale

(2012) Qiangfeng Cliff Zhang et al.   NATURE

Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins

(2012) L. Roglin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression

(2011) Negar Asdaghi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

(2011) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microarray-Assisted High-Throughput Identification of a Cell-Permeable Small-Molecule Binder of 14-3-3 Proteins

(2010) Hao Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioinformatic and experimental survey of 14-3-3-binding sites

(2010) Catherine Johnson et al.   BIOCHEMICAL JOURNAL

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

(2010) Valentina Corradi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The First Small-Molecule Inhibitor of 14-3-3s: Modulating the Master Regulator

(2010) Markus Kaiser  et al.   CHEMBIOCHEM

14-3-3  associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1

(2010) A. Ghaffari et al.   JOURNAL OF CELL SCIENCE

The moonlighting enzyme CD13: old and new functions to target

(2008) Paola Mina-Osorio   TRENDS IN MOLECULAR MEDICINE