Histone Deacetylase 6 (HDAC6) Promotes the Pro-survival Activity of 14-3-3ζ via Deacetylation of Lysines within the 14-3-3ζ Binding Pocket

Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative Diseases

(2014) Jin Yan   DNA AND CELL BIOLOGY

Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

(2014) Pablo Garrido et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

(2014) Mu Zhang et al.   MOLECULAR CELL

Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers

(2013) Manuela Molzan et al.   ACS Chemical Biology

A Time-Resolved Fluorescence Resonance Energy Transfer Assay for High-Throughput Screening of 14-3-3 Protein–Protein Interaction Inhibitors

(2013) Yuhong Du et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Interaction of 14-3-3ζ with Microtubule-Associated Protein Tau within Alzheimer’s Disease Neurofibrillary Tangles

(2013) Hamid Y. Qureshi et al.   BIOCHEMISTRY

Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration

(2013) Kendra A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

(2013) Z. Xu et al.   JOURNAL OF CELL SCIENCE

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy

(2012) S. K. McBrayer et al.   BLOOD

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers

(2012) Anna Bergamaschi et al.   BREAST CANCER RESEARCH AND TREATMENT

14-3-3 zeta as novel molecular target for cancer therapy

(2012) Ajay Matta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

(2012) Lei Wang et al.   PLoS One

Targeting 14-3-3zeta in cancer therapy

(2011) X Yang et al.   CANCER GENE THERAPY

A Biotin Switch-Based Proteomics Approach Identifies 14-3-3ζ as a Target of Sirt1 in the Metabolic Regulation of Caspase-2

(2011) Joshua L. Andersen et al.   MOLECULAR CELL

14-3-3 proteins as potential therapeutic targets

(2011) Jing Zhao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

(2011) Shuai Chen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

14-3-3ζ as a prognostic marker and therapeutic target for cancer

(2010) Christopher L Neal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis

(2010) Mercedes Pozuelo-Rubio   FEBS Journal

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Identification of Novel 14-3-3ζ Interacting Proteins by Quantitative Immunoprecipitation Combined with Knockdown (QUICK)

(2010) Feng Ge et al.   JOURNAL OF PROTEOME RESEARCH

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

(2010) M. Namdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

14-3-3ζ Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

(2009) Jing Lu et al.   CANCER CELL

14-3-3  Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival

(2009) C. L. Neal et al.   CANCER RESEARCH

Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2

(2009) Leta K. Nutt et al.   DEVELOPMENTAL CELL

Copy number gain and oncogenic activity of YWHAZ/14-3-3ζ in head and neck squamous cell carcinoma

(2009) Mauting Lin et al.   INTERNATIONAL JOURNAL OF CANCER

14-3-3ζ Mediates Resistance of Diffuse Large B Cell Lymphoma to an Anthracycline-based Chemotherapeutic Regimen

(2009) Steve A. Maxwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAD: undertaker by night, candyman by day

(2009) N N Danial   ONCOGENE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Glucose Transporter 4 Translocation by the Rab Guanosine Triphosphatase-Activating Protein AS160/TBC1D4: Role of Phosphorylation and Membrane Association

(2008) Jacqueline Stöckli et al.   MOLECULAR ENDOCRINOLOGY