Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface

(2013) Carolin Anders et al.   CHEMISTRY & BIOLOGY

Stabilization and Inhibition of Protein–Protein Interactions: The 14-3-3 Case Study

(2012) Lech-Gustav Milroy et al.   ACS Chemical Biology

Small-molecule modulators of 14-3-3 protein–protein interactions

(2012) Christian Ottmann   BIOORGANIC & MEDICINAL CHEMISTRY

An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction

(2012) Anja Richter et al.   CHEMISTRY-A EUROPEAN JOURNAL

Moving to the Core: Spatiotemporal Analysis of Forkhead Box O (FOXO) and Nuclear Factor-κB (NF-κB) Nuclear Translocation

(2012) Fabian Zanella et al.   TRAFFIC

Clinical implication of 14-3-3 epsilon expression in gastric cancer

(2012) Mariana Ferreira Leal   WORLD JOURNAL OF GASTROENTEROLOGY

The role of paclitaxel in the development and treatment of multidrug resistant cancer cell lines

(2011) Ana Podolski-Renić et al.   BIOMEDICINE & PHARMACOTHERAPY

Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case

(2011) Valentina Corradi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer

(2011) Wei-hua Zhou et al.   BMC CANCER

Protein localization in disease and therapy

(2011) M.-C. Hung et al.   JOURNAL OF CELL SCIENCE

Visualization and Biochemical Analyses of the Emerging Mammalian 14-3-3-Phosphoproteome

(2011) Catherine Johnson et al.   MOLECULAR & CELLULAR PROTEOMICS

14-3-3  regulates B-cell homeostasis through stabilization of FOXO1

(2011) Y.-W. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of 14-3-3 protein functions

(2011) Tomas Obsil et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The 14-3-3 proteins in regulation of cellular metabolism

(2011) Rune Kleppe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microarray-Assisted High-Throughput Identification of a Cell-Permeable Small-Molecule Binder of 14-3-3 Proteins

(2010) Hao Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions

(2010) Rolf Rose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

(2010) Valentina Corradi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693

(2010) Rakesh Kumar et al.   BMC GENOMICS

The expression of seven 14-3-3 isoforms in human meningioma

(2010) Yang Liu et al.   BRAIN RESEARCH

14-3-3ζ Overexpression and abnormal β-catenin expression are associated with poor differentiation and progression in stage I non-small cell lung cancer

(2010) Dongyu Zang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

14-3-3ζ as a prognostic marker and therapeutic target for cancer

(2010) Christopher L Neal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A New Nonpeptidic Inhibitor of 14-3-3 Induces Apoptotic Cell Death in Chronic Myeloid Leukemia Sensitive or Resistant to Imatinib

(2010) M. Mancini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators

(2009) Fabian Zanella et al.   BMC CELL BIOLOGY

Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases

(2009) Wolfgang Link et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Genetic Analysis of FOXO Nuclear-Cytoplasmic Shuttling by Using Image-Based Cell Screening

(2008) Fabian Zanella et al.   CHEMBIOCHEM

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY

A computational method for the analysis and prediction of protein:phosphopeptide-binding sites

(2004) Brian A. Joughin et al.   PROTEIN SCIENCE