Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia

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The heat-shock, or HSF1-mediated proteotoxic stress, response in cancer: from proteomic stability to oncogenesis

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Common nonmutationalNOTCH1activation in chronic lymphocytic leukemia

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Rethinking HSF1 in Stress, Development, and Organismal Health

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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

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Drugging the addict: non‐oncogene addiction as a target for cancer therapy

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Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation

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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

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The epichaperome is an integrated chaperome network that facilitates tumour survival

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HSF1: Guardian of Proteostasis in Cancer

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MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

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The Chemical Biology of Molecular Chaperones—Implications for Modulation of Proteostasis

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HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

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FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

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Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

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A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

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The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

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Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

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The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

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NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

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Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

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STAR: ultrafast universal RNA-seq aligner

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HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

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Heat Shock Factor Hsf1 Cooperates with ErbB2 (Her2/Neu) Protein to Promote Mammary Tumorigenesis and Metastasis

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NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

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Fast gapped-read alignment with Bowtie 2

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mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

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Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy

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Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

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Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

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Promotion of Heat Shock Factor Hsf1 Degradation via Adaptor Protein Filamin A-interacting Protein 1-Like (FILIP-1L)

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ETV6mutations in early immature human T cell leukemias

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Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

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Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

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Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis

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A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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The Human Epigenome Browser at Washington University

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Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

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c-Myc Regulates Transcriptional Pause Release

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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Heat shock factors: integrators of cell stress, development and lifespan

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Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

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Inhibiting the transcription factor HSF1 as an anticancer strategy

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

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STRING 8--a global view on proteins and their functional interactions in 630 organisms

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Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

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