Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Early replication fragile sites: where replication–transcription collisions cause genetic instability

(2013) Oliver Mortusewicz et al.   EMBO JOURNAL

Common chromosome fragile sites in human and murine epithelial cells andFHIT/FRA3Bloss-induced global genome instability

(2013) Seyed Ali Hosseini et al.   GENES CHROMOSOMES & CANCER

The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability

(2013) Jennifer M. Mason et al.   HUMAN MOLECULAR GENETICS

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

(2013) Anne-Sophie Boyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D

(2013) Xing Lu et al.   Molecular Cancer

A blooming resolvase at chromosomal fragile sites

(2013) Achille Pellicioli et al.   NATURE CELL BIOLOGY

Large scale chromosomal mapping of human microRNA structural clusters

(2013) Anthony Mathelier et al.   NUCLEIC ACIDS RESEARCH

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells

(2013) Audesh Bhat et al.   NUCLEIC ACIDS RESEARCH

Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines

(2013) Anne Gibaud et al.   NUCLEIC ACIDS RESEARCH

CTCF: the protein, the binding partners, the binding sites and their chromatin loops

(2013) S. J. B. Holwerda et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

DNA Topoisomerases Participate in Fragility of the Oncogene RET

(2013) Laura W. Dillon et al.   PLoS One

Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement

(2013) Ruth N. MacKinnon et al.   Cancer Genetics

Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites

(2013) Assaf C. Bester et al.   Scientific Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

(2013) Stéphane Koundrioukoff et al.   PLoS Genetics

Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability

(2013) Annapaola Franchitto   Biomed Research International

Chromatin condensation dynamics and implications of induced premature chromosome condensation

(2012) Maddaly Ravi et al.   BIOCHIMIE

Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats

(2012) Lena M. Brueckner et al.   HUMAN GENETICS

Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

(2012) Ke Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication

(2012) Erin Walsh et al.   JOURNAL OF MOLECULAR BIOLOGY

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

2′-Deoxyriboguanylurea, the primary breakdown product of 5-aza-2′-deoxyribocytidine, is a mutagen, an epimutagen, an inhibitor of DNA methyltransferases and an inducer of 5-azacytidine-type fragile sites

(2012) Katarzyna Lamparska et al.   NUCLEIC ACIDS RESEARCH

The complex basis underlying common fragile site instability in cancer

(2012) Efrat Ozeri-Galai et al.   TRENDS IN GENETICS

Severe intellectual disability, omphalocele, hypospadia and high blood pressure associated to a deletion at 2q22.1q22.3: case report

(2012) Milene Mulatinho et al.   Molecular Cytogenetics

Topoisomerase II– and Condensin-Dependent Breakage of MEC1ATR-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis

(2012) Nadia Hashash et al.   PLoS Genetics

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Understanding the molecular basis of common fragile sites instability: Role of the proteins involved in the recovery of stalled replication forks

(2011) Annapaola Franchitto et al.   CELL CYCLE

The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers

(2011) Anne Blumrich et al.   HUMAN MOLECULAR GENETICS

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

(2011) Maria Sideridou et al.   JOURNAL OF CELL BIOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

(2011) Efrat Ozeri-Galai et al.   MOLECULAR CELL

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

(2011) Aygül Dereli-Öz et al.   Molecular Oncology

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Molecular profiling of common fragile sites in human fibroblasts

(2011) Benoî Le Tallec et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Ensembl BioMarts: a hub for data retrieval across taxonomic space

(2011) R. J. Kinsella et al.   Database-The Journal of Biological Databases and Curation

Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region

(2010) Nazario Bosco et al.   CANCER GENETICS AND CYTOGENETICS

Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 – Molecular characterization of FRA2H and localization of a new CFS FRA2S

(2010) Franca Pelliccia et al.   CANCER LETTERS

Replication dynamics at common fragile site FRA6E

(2010) Elisa Palumbo et al.   CHROMOSOMA

DNA Instability at Chromosomal Fragile Sites in Cancer

(2010) Laura W. Dillon et al.   CURRENT GENOMICS

Deletion at Fragile Sites Is a Common and Early Event in Barrett's Esophagus

(2010) L. A. Lai et al.   MOLECULAR CANCER RESEARCH

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

(2010) M Gandhi et al.   ONCOGENE

Variability in the Incidence of miRNAs and Genes in Fragile Sites and the Role of Repeats and CpG Islands in the Distribution of Genetic Material

(2010) Alessandro Laganà et al.   PLoS One

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GeneCards Version 3: the human gene integrator

(2010) M. Safran et al.   Database-The Journal of Biological Databases and Curation

Methylated H3K4, a Transcription-Associated Histone Modification, Is Involved in the DNA Damage Response Pathway

(2010) David Faucher et al.   PLoS Genetics

Genome wide DNA-profiling of HIV-related B-cell lymphomas

(2009) Daniela Capello et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Claspin inhibition leads to fragile site expression

(2009) Maria Luisa Focarelli et al.   GENES CHROMOSOMES & CANCER

Common fragile sites are characterized by histone hypoacetylation

(2009) Yanwen Jiang et al.   HUMAN MOLECULAR GENETICS

Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions

(2008) E. Darai-Ramqvist et al.   GENOME RESEARCH

Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor

(2008) P.V. Peña et al.   JOURNAL OF MOLECULAR BIOLOGY

The Insulator Binding Protein CTCF Positions 20 Nucleosomes around Its Binding Sites across the Human Genome

(2008) Yutao Fu et al.   PLoS Genetics