Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes

Alkaloid Cluster Gene ccsA of the Ergot Fungus Claviceps purpurea Encodes Chanoclavine I Synthase, a Flavin Adenine Dinucleotide-Containing Oxidoreductase Mediating the Transformation of N-Methyl-Dimethylallyltryptophan to Chanoclavine I

(2010) N. Lorenz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An Old Yellow Enzyme Gene Controls the Branch Point between Aspergillus fumigatus and Claviceps purpurea Ergot Alkaloid Pathways

(2010) C. M. Coyle et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Postpartum Hemorrhage: Evidence-based Medical Interventions for Prevention and Treatment

(2010) PRIYA V. RAJAN et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

New therapeutic developments in chronic migraine

(2010) Brigitte V Lovell et al.   CURRENT OPINION IN NEUROLOGY

Genome-Based Characterization of Two Prenylation Steps in the Assembly of the Stephacidin and Notoamide Anticancer Agents in a Marine-DerivedAspergillussp.

(2010) Yousong Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Role for Old Yellow Enzyme in Ergot Alkaloid Biosynthesis

(2010) Johnathan Z. Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlling a Structural Branch Point in Ergot Alkaloid Biosynthesis

(2010) Johnathan Z. Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asexual Endophytes in a Native Grass: Tradeoffs in Mortality, Growth, Reproduction, and Alkaloid Production

(2010) Stanley H. Faeth et al.   MICROBIAL ECOLOGY

Reconstruction of pyrrolo[2,3-b]indoles carrying an α-configured reverse C3-dimethylallyl moiety by using recombinant enzymes

(2010) Wen-Bing Yin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3

(2010) Christiane Wallwey et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Preparation of pyrrolo[2,3-b]indoles carrying a β-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT

(2010) Wen-Bing Yin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Management of Migraine Headache in the Emergency Department

(2010) Carrie Robertson et al.   SEMINARS IN NEUROLOGY

Cluster Headache: Diagnosis and Treatment

(2010) Rashmi Halker et al.   SEMINARS IN NEUROLOGY

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

(2010) Anne Osbourn   TRENDS IN GENETICS

Applications of dimethylallyltryptophan synthases and other indole prenyltransferases for structural modification of natural products

(2009) Shu-Ming Li   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH

(2009) Christiane Wallwey et al.   ARCHIVES OF MICROBIOLOGY

Increasing structure diversity of prenylated diketopiperazine derivatives by using a 4-dimethylallyltryptophan synthase

(2009) Nicola Steffan et al.   ARCHIVES OF MICROBIOLOGY

Ergot Alkaloid Biosynthesis inAspergillus fumigatus: FgaAT Catalyses the Acetylation of Fumigaclavine B

(2009) Xiaoqing Liu et al.   CHEMBIOCHEM

Combinatorial Assembly of Simple and Complex d-Lysergic Acid Alkaloid Peptide Classes in the Ergot FungusClaviceps purpurea

(2009) Ingo Ortel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aromatic Prenylation in Phenazine Biosynthesis

(2009) Orwah Saleh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive Alkaloids from EndophyticAspergillus fumigatus

(2009) Hui Ming Ge et al.   JOURNAL OF NATURAL PRODUCTS

Mechanism of Dimethylallyltryptophan Synthase: Evidence for a Dimethylallyl Cation Intermediate in an Aromatic Prenyltransferase Reaction

(2009) Louis Y. P. Luk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL

(2009) A. Kremer et al.   MICROBIOLOGY-SGM

Ergot: from witchcraft to biotechnology

(2009) THOMAS HAARMANN et al.   MOLECULAR PLANT PATHOLOGY

New natural product biosynthetic chemistry discovered by genome mining

(2009) Christophe Corre et al.   NATURAL PRODUCT REPORTS

Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

(2009) Shu-Ming Li   NATURAL PRODUCT REPORTS

PKS and NRPS release mechanisms

(2009) Liangcheng Du et al.   NATURAL PRODUCT REPORTS

Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases

(2009) Wen-Bing Yin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Systematic review of the effect of dopamine receptor agonists on patient health-related quality of life

(2009) Pablo Martinez-Martin et al.   PARKINSONISM & RELATED DISORDERS

Role of dopamine receptor agonists in the treatment of early Parkinson's disease

(2009) Ubaldo Bonuccelli et al.   PARKINSONISM & RELATED DISORDERS

Prenylation of aromatic compounds, a key diversification of plant secondary metabolites

(2009) Kazufumi Yazaki et al.   PHYTOCHEMISTRY

Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives

(2009) Shu-Ming Li   PHYTOCHEMISTRY

The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects

(2009) Nicole Lorenz et al.   PHYTOCHEMISTRY

Toxicity of Endophyte-Infected Tall Fescue Alkaloids and Grass Metabolites onPratylenchus scribneri

(2009) A. A. Bacetty et al.   PHYTOPATHOLOGY

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria

(2009) U. Metzger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Lysine Residues are Responsible for the Enzymatic Activities of Indole Prenyltransferases from Fungi

(2008) Edyta Stec et al.   CHEMBIOCHEM

Indole Prenyltransferases from Fungi: A New Enzyme Group with High Potential for the Production of Prenylated Indole Derivatives

(2008) N. Steffan et al.   CURRENT MEDICINAL CHEMISTRY

Ergot Alkaloid Biosynthesis inAspergillus fumigatus

(2008) Ole Rigbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Analysis of a 4-Dimethylallyltryptophan Synthase fromMalbranchea aurantiaca

(2008) Yousong Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics ofAspergillus fumigatus

(2008) Jens C. Frisvad et al.   MEDICAL MYCOLOGY

Biosynthesis and Accumulation of Ergoline Alkaloids in a Mutualistic Association between Ipomoea asarifolia (Convolvulaceae) and a Clavicipitalean Fungus

(2008) A. Markert et al.   PLANT PHYSIOLOGY

Lactam ergot alkaloids (ergopeptams) as predominant alkaloids in sclerotia of Claviceps purpurea from Norwegian wild grasses

(2008) Silvio Uhlig et al.   TOXICON

Use of a nonhomologous end joining deficient strain (Δku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis

(2007) Thomas Haarmann et al.   FUNGAL GENETICS AND BIOLOGY