Flavoenzymes: Versatile catalysts in biosynthetic pathways

Elucidating the Biosynthetic Pathway for the Polyketide-Nonribosomal Peptide Collismycin A: Mechanism for Formation of the 2,2′-bipyridyl Ring

(2012) Ignacio Garcia et al.   CHEMISTRY & BIOLOGY

A functional screen for recovery of 4′-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries

(2012) J. G. Owen et al.   ENVIRONMENTAL MICROBIOLOGY

Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis

(2012) Atsushi Minami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of Aminovinyl-Cysteine-Containing Peptides and Its Application in the Production of Potential Drug Candidates

(2011) Clarissa S. Sit et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chemical Logic and Enzymatic Machinery for Biological Assembly of Peptidyl Nucleoside Antibiotics

(2011) Christopher T. Walsh et al.   ACS Chemical Biology

Structure Determination and Interception of Biosynthetic Intermediates for the Plantazolicin Class of Highly Discriminating Antibiotics

(2011) Katie J. Molohon et al.   ACS Chemical Biology

Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks

(2011) Christopher T. Walsh et al.   ACS Chemical Biology

Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: Oxidation of Fumiquinazoline A to the Heptacyclic Hemiaminal Fumiquinazoline C by the Flavoenzyme Af12070 fromAspergillus fumigatus

(2011) Brian D. Ames et al.   BIOCHEMISTRY

Flavoprotein Hydroxylase PgaE Catalyzes Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis

(2011) Pauli Kallio et al.   BIOCHEMISTRY

Streptomyces clavuligerusHlmI Is an Intramolecular Disulfide-Forming Dithiol Oxidase in Holomycin Biosynthesis

(2011) Bo Li et al.   BIOCHEMISTRY

Stereochemical Studies of the Type II Isopentenyl Diphosphate-Dimethylallyl Diphosphate Isomerase Implicate the FMN Coenzyme in Substrate Protonation

(2011) Jordi Calveras et al.   CHEMBIOCHEM

The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus

(2011) Carol Davis et al.   CHEMISTRY & BIOLOGY

Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus

(2011) John W. Phillips et al.   CHEMISTRY & BIOLOGY

Nucleophilic Participation of Reduced Flavin Coenzyme in Mechanism of UDP-galactopyranose Mutase

(2011) He G. Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis

(2011) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snapshots of Enzymatic Baeyer-Villiger Catalysis

(2011) Roberto Orru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of NotB as an FAD-Dependent Oxidase in the Biosynthesis of Notoamide Indole Alkaloids

(2011) Shengying Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fungal Indole Alkaloid Biosynthesis: Genetic and Biochemical Investigation of the Tryptoquialanine Pathway inPenicillium aethiopicum

(2011) Xue Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biogenesis of the Unique 4′,5′-Dehydronucleoside of the Uridyl Peptide Antibiotic Pacidamycin

(2011) Amany E. Ragab et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

(2011) Madan K. Kharel et al.   NATURAL PRODUCT REPORTS

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

(2011) Yu-Chen Liu et al.   Nature Chemical Biology

Plantazolicin A and B: Structure Elucidation of Ribosomally Synthesized Thiazole/Oxazole Peptides fromBacillus amyloliquefaciensFZB42

(2011) Bahar Kalyon et al.   ORGANIC LETTERS

Current understanding of fatty acid biosynthesis and the acyl carrier protein

(2010) David I. Chan et al.   BIOCHEMICAL JOURNAL

Enzymatic Processing of Fumiquinazoline F: A Tandem Oxidative-Acylation Strategy for the Generation of Multicyclic Scaffolds in Fungal Indole Alkaloid Biosynthesis

(2010) Brian D. Ames et al.   BIOCHEMISTRY

Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes

(2010) Chantel D. Campbell et al.   BIOPOLYMERS

Solanapyrone Synthase, a Possible Diels-Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani

(2010) Ken Kasahara  et al.   CHEMBIOCHEM

Thiazolyl Peptide Antibiotic Biosynthesis: A Cascade of Post-translational Modifications on Ribosomal Nascent Proteins

(2010) Christopher T. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin–Aspartate Bond

(2010) Kateryna Podzelinska et al.   JOURNAL OF MOLECULAR BIOLOGY

Catalysis of a Flavoenzyme-Mediated Amide Hydrolysis

(2010) Tathagata Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linear Free Energy Relationships Demonstrate a Catalytic Role for the Flavin Mononucleotide Coenzyme of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase

(2010) Christopher J. Thibodeaux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin

(2010) Markus Schrettl et al.   PLoS Pathogens

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Control of catalysis in flavin-dependent monooxygenases

(2009) Bruce A. Palfey et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Crystal Structures of Intermediates in the Nitroalkane Oxidase Reaction†‡

(2009) Annie Héroux et al.   BIOCHEMISTRY

Characterization ofcyclo-Acetoacetyl-l-Tryptophan Dimethylallyltransferase in Cyclopiazonic Acid Biosynthesis: Substrate Promiscuity and Site Directed Mutagenesis Studies

(2009) Xinyu Liu et al.   BIOCHEMISTRY

Crystallographic, Spectroscopic, and Computational Analysis of a Flavin C4a−Oxygen Adduct in Choline Oxidase†,‡

(2009) Allen M. Orville et al.   BIOCHEMISTRY

X-ray Crystallography Reveals a Reduced Substrate Complex of UDP-Galactopyranose Mutase Poised for Covalent Catalysis by Flavin,

(2009) Todd D. Gruber et al.   BIOCHEMISTRY

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

Genome Mining inStreptomyces avermitilis: A Biochemical Baeyer−Villiger Reaction and Discovery of a New Branch of the Pentalenolactone Family Tree

(2009) Jiaoyang Jiang et al.   BIOCHEMISTRY

Crystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,

(2009) Miranda P. Beam et al.   BIOCHEMISTRY

An FAD-Dependent Pyridine Nucleotide-Disulfide Oxidoreductase Is Involved in Disulfide Bond Formation in FK228 Anticancer Depsipeptide

(2009) Cheng Wang et al.   CHEMISTRY & BIOLOGY

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

(2009) Xiaofeng Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage of Four Carbon−Carbon Bonds during Biosynthesis of the Griseorhodin A Spiroketal Pharmacophore

(2009) Zeynep Yunt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate/Dimethylallyl Diphosphate Isomerase fromStaphylococcus aureus†

(2008) Christopher J. Thibodeaux et al.   BIOCHEMISTRY

Sequential Action of Two Flavoenzymes, PgaE and PgaM, in Angucycline Biosynthesis: Chemoenzymatic Synthesis of Gaudimycin C

(2008) Pauli Kallio et al.   CHEMISTRY & BIOLOGY

Halogenation Strategies In Natural Product Biosynthesis

(2008) Christopher S. Neumann et al.   CHEMISTRY & BIOLOGY

Cofactor biosynthesis—still yielding fascinating new biological chemistry

(2008) Tadhg P Begley et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mechanism and Regulation of the Two-component FMN-dependent Monooxygenase ActVA-ActVB fromStreptomyces coelicolor

(2008) Julien Valton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tandem Action of the O2- and FADH2-Dependent Halogenases KtzQ and KtzR Produce 6,7-Dichlorotryptophan for Kutzneride Assembly

(2008) John R. Heemstra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyunsaturated Fatty-Acid-LikeTrans-Enoyl Reductases Utilized in Polyketide Biosynthesis

(2008) Stefanie B. Bumpus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

(2008) Elizabeth S. Sattely et al.   NATURAL PRODUCT REPORTS

The Chemical Versatility of Natural-Product Assembly Lines

(2007) Christopher T. Walsh   ACCOUNTS OF CHEMICAL RESEARCH