Biosynthesis of fungal meroterpenoids

Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem

(2015) Chengwei Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional Characterization of MpaG′, the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid

(2015) Wei Zhang et al.   CHEMBIOCHEM

Uncovering the Unusual D-Ring Construction in Terretonin Biosynthesis by Collaboration of a Multifunctional Cytochrome P450 and a Unique Isomerase

(2015) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids

(2015) Yi Zou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic studies on the indole prenyltransferases

(2015) Martin E. Tanner   NATURAL PRODUCT REPORTS

New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression

(2015) Chih-Chuang Liaw et al.   ORGANIC LETTERS

Meroterpenoid, isocoumarin, and phenol derivatives from the seagrass-derived fungus Pestalotiopsis sp. PSU-ES194

(2015) Jiraporn Arunpanichlert et al.   TETRAHEDRON

Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens

(2015) Junko Yaegashi et al.   Chemical Science

Molecular Cloning and Functional Analysis of Gene Clusters for the Biosynthesis of Indole-Diterpenes in Penicillium crustosum and P. janthinellum

(2015) Matthew Nicholson et al.   Toxins

Highly Selective but Multifunctional Oxygenases in Secondary Metabolism

(2014) Rachel V. K. Cochrane et al.   ACCOUNTS OF CHEMICAL RESEARCH

Non-Heme Dioxygenase Catalyzes Atypical Oxidations of 6,7-Bicyclic Systems To Form the 6,6-Quinolone Core of Viridicatin-Type Fungal Alkaloids

(2014) Noriyasu Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of two acetyltransferase genes in the pyripyropene biosynthetic gene cluster fromPenicillium coprobium

(2014) Jie Hu et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites inAspergillus oryzae: Total Biosynthesis of Aflatrem

(2014) Koichi Tagami et al.   CHEMBIOCHEM

Molecular and Chemical Characterization of the Biosynthesis of the 6-MSA-Derived Meroterpenoid Yanuthone D in Aspergillus niger

(2014) Dorte K. Holm et al.   CHEMISTRY & BIOLOGY

Terretonin G, a new sesterterpenoid antibiotic from marine-derived Aspergillus sp. OPMF00272

(2014) Takashi Fukuda et al.   JOURNAL OF ANTIBIOTICS

Characterization of four new antifungal yanuthones from Aspergillus niger

(2014) Lene M Petersen et al.   JOURNAL OF ANTIBIOTICS

Dhilirolides E–N, Meroterpenoids Produced in Culture by the Fungus Penicillium purpurogenum Collected in Sri Lanka: Structure Elucidation, Stable Isotope Feeding Studies, and Insecticidal Activity

(2014) Ryan M. Centko et al.   JOURNAL OF ORGANIC CHEMISTRY

Complete Biosynthetic Pathway of Anditomin: Nature’s Sophisticated Synthetic Route to a Complex Fungal Meroterpenoid

(2014) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Methyltransferase Initiates Terpene Cyclization in Teleocidin B Biosynthesis

(2014) Takayoshi Awakawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway

(2014) Hsiao-Ching Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative rearrangements during fungal biosynthesis

(2014) Russell Cox   NATURAL PRODUCT REPORTS

Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations

(2014) Huixian Li et al.   ORGANIC LETTERS

Structural Insights into Ubiquinone Biosynthesis in Membranes

(2014) W. Cheng et al.   SCIENCE

Allosteric Regulation of Epoxide Opening Cascades by a Pair of Epoxide Hydrolases in Monensin Biosynthesis

(2013) Atsushi Minami et al.   ACS Chemical Biology

Regiospecificities and Prenylation Mode Specificities of the Fungal Indole Diterpene Prenyltransferases AtmD and PaxD

(2013) Chengwei Liu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster

(2013) Chengwei Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ubiI,a New Gene inEscherichia coliCoenzyme Q Biosynthesis, Is Involved in Aerobic C5-hydroxylation

(2013) Mahmoud Hajj Chehade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene

(2013) Hsiao-Ching Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cytochrome P450 Serves as an Unexpected Terpene Cyclase during Fungal Meroterpenoid Biosynthesis

(2013) Yit-Heng Chooi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spiro-Ring Formation is Catalyzed by a Multifunctional Dioxygenase in Austinol Biosynthesis

(2013) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline in Aspergillus oryzae

(2013) Koichi Tagami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans

(2013) Junko Yaegashi et al.   ORGANIC LETTERS

Reconstituted biosynthesis of fungal meroterpenoid andrastin A

(2013) Yudai Matsuda et al.   TETRAHEDRON

Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli

(2013) Barry Scott et al.   Toxins

Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

(2012) Bjarne Gram Hansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of a Key Prenyltransferase Involved in Biosynthesis of the Most Abundant Fungal Meroterpenoids Derived from 3,5-Dimethylorsellinic Acid.

(2012) Takayuki Itoh et al.   CHEMBIOCHEM

Terretonin Biosynthesis Requires Methylation as Essential Step for Cyclization

(2012) Yudai Matsuda et al.   CHEMBIOCHEM

Terpendole E, a Kinesin Eg5 Inhibitor, Is a Key Biosynthetic Intermediate of Indole-Diterpenes in the Producing Fungus Chaunopycnis alba

(2012) Takayuki Motoyama et al.   CHEMISTRY & BIOLOGY

Anti-inflammatory effect of berkeleyacetal C through the inhibition of interleukin-1 receptor-associated kinase-4 activity

(2012) Tadahiro Etoh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Functional analysis of an indole-diterpene gene cluster for lolitrem B biosynthesis in the grass endosymbiontEpichloë festucae

(2012) Sanjay Saikia et al.   FEBS LETTERS

Meroterpenoid and Diphenyl Ether Derivatives from Penicillium sp. MA-37, a Fungus Isolated from Marine Mangrove Rhizospheric Soil

(2012) Yi Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Discovery and Characterization of a Group of Fungal Polycyclic Polyketide Prenyltransferases

(2012) Yit-Heng Chooi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans

(2012) Hsien-Chun Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Merochlorins A–D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases

(2012) Leonard Kaysser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

(2012) Chun-Jun Guo et al.   ORGANIC LETTERS

Terretonin, ophiobolin, and drimaneterpenes with absolute configurations from an algicolous Aspergillus ustus

(2012) Xiang-Hong Liu et al.   RSC Advances

Versatile Enzyme Expression and Characterization System for Aspergillus nidulans, with the Penicillium brevicompactum Polyketide Synthase Gene from the Mycophenolic Acid Gene Cluster as a Test Case

(2011) Bjarne G. Hansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

(2011) Torsten Bak Regueira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Novel terpenoids of the fungus Aspergillus insuetus isolated from the Mediterranean sponge Psammocinia sp. collected along the coast of Israel

(2011) Elazar Cohen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

(2011) Naoki Kato et al.   CHEMBIOCHEM

A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans

(2011) Michael L. Nielsen et al.   FEMS MICROBIOLOGY LETTERS

Characterization of two cytochrome P450 monooxygenase genes of the pyripyropene biosynthetic gene cluster from Penicillium coprobium

(2011) Jie Hu et al.   JOURNAL OF ANTIBIOTICS

Berkeleyones and Related Meroterpenes from a Deep Water Acid Mine Waste Fungus That Inhibit the Production of Interleukin 1-β from Induced Inflammasomes

(2011) Donald B. Stierle et al.   JOURNAL OF NATURAL PRODUCTS

Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-like Cyclization Catalyzed by a Dimanganese Thioesterase

(2011) Yanran Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dhilirolides A−D, Meroterpenoids Produced in Culture by the Fruit-Infecting FungusPenicillium purpurogenumCollected in Sri Lanka

(2011) E. Dilip de Silva et al.   ORGANIC LETTERS

Emervaridione and varioxiranediol, two new metabolites from the endophytic fungus, Emericella variecolor

(2011) Jatupol Liangsakul et al.   TETRAHEDRON LETTERS

Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

(2010) Yit-Heng Chooi et al.   CHEMISTRY & BIOLOGY

Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans

(2010) Kirstin Scherlach et al.   JOURNAL OF ANTIBIOTICS

Chemical Epigenetics Alters the Secondary Metabolite Composition of Guttate Excreted by an Atlantic-Forest-Soil-DerivedPenicillium citreonigrum

(2010) Xiaoru Wang et al.   JOURNAL OF NATURAL PRODUCTS

Not just passing through

(2010) Jason M. Crawford et al.   Nature Chemistry

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases

(2010) Takayuki Itoh et al.   Nature Chemistry

Identification of Two Aflatrem Biosynthesis Gene Loci in Aspergillus flavus and Metabolic Engineering of Penicillium paxilli To Elucidate Their Function

(2009) M. J. Nicholson et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived FungusAspergillus insuetus#

(2009) M. Pilar López-Gresa et al.   JOURNAL OF NATURAL PRODUCTS

Meroterpenoids produced by fungi

(2009) Regina Geris et al.   NATURAL PRODUCT REPORTS

Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

(2009) Shu-Ming Li   NATURAL PRODUCT REPORTS

FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

(2009) Nicola Steffan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the  / -hydrolase fold

(2009) R. A. Steiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nature-inspired Diels–Alder reaction facilitates construction of the bicyclo[2.2.2]octane core of andibenin B

(2009) Jillian E. Spangler et al.   TETRAHEDRON

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

(2008) Elena G Kovaleva et al.   Nature Chemical Biology

Three New Polyketide−Terpenoid Hybrids fromPenicilliumsp.

(2008) Motoo Iida et al.   ORGANIC LETTERS

Novofumigatonin, a New Orthoester Meroterpenoid fromAspergillus novofumigatus

(2008) Christian Rank et al.   ORGANIC LETTERS