Antibacterial properties and clinical potential of pleuromutilins

Transition-Metal-Catalyzed Selective Functionalization of C(sp3 )−H Bonds in Natural Products

(2018) Rashad R. Karimov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed C–H Bond Oxidation of (+)-Pleuromutilin

(2018) Xiaoshen Ma et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Pleuromutilin

(2018) Elliot P. Farney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and antibacterial evaluation of novel pleuromutilin derivatives possessing piperazine linker

(2017) Mei-Ling Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety

(2017) Yunpeng Yi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The antibiotic resistance crisis, with a focus on the United States

(2017) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Development of a Modular Synthetic Route to (+)-Pleuromutilin, (+)-12-epi-Mutilins, and Related Structures

(2017) Mingshuo Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular, Scalable Synthesis of Group A Streptogramin Antibiotics

(2017) Qi Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Biological Activity Evaluation of Novel Heterocyclic Pleuromutilin Derivatives

(2017) et al.   MOLECULES

Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics

(2017) Stephen K. Murphy et al.   ORGANIC LETTERS

A modular and enantioselective synthesis of the pleuromutilin antibiotics

(2017) Stephen K. Murphy et al.   SCIENCE

Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives

(2017) Fabrizio Alberti et al.   Nature Communications

In VitroActivity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States

(2016) Rodrigo E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, synthesis, and structure-activity relationship studies of novel pleuromutilin derivatives having a piperazine ring

(2016) Jian Luo et al.   Chemical Biology & Drug Design

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics

(2016) Fan Liu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A platform for the discovery of new macrolide antibiotics

(2016) Ian B. Seiple et al.   NATURE

Stereoselective Multicomponent Reactions Using Zincate Nucleophiles: β-Dicarbonyl Synthesis and Functionalization

(2016) Stephen K. Murphy et al.   ORGANIC LETTERS

Pleuromutilins: Potent Drugs for Resistant Bugs—Mode of Action and Resistance

(2016) Susanne Paukner et al.   Cold Spring Harbor Perspectives in Medicine

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production

(2016) Andy M. Bailey et al.   Scientific Reports

A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism

(2016) Zohar Eyal et al.   Scientific Reports

Mechanistic Basis for Regioselection and Regiodivergence in Nickel-Catalyzed Reductive Couplings

(2015) Evan P. Jackson et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives

(2015) Huixian Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and evaluation of novel pleuromutilin derivatives with a substituted pyrimidine moiety

(2015) Yunpeng Yi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Horizontal gene transmission of thecfrgene to MRSA andEnterococcus: role ofStaphylococcus epidermidisas a reservoir and alternative pathway for the spread of linezolid resistance

(2015) Fabio Cafini et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Stable TEMPO and ABNO Catalyst Solutions for User-Friendly (bpy)Cu/Nitroxyl-Catalyzed Aerobic Alcohol Oxidation

(2015) Janelle E. Steves et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Adjacent Quaternary Stereocenters by Catalytic Asymmetric Allylboration

(2015) Rauful Alam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A manganese catalyst for highly reactive yet chemoselective intramolecular C(sp3)–H amination

(2015) Shauna M. Paradine et al.   Nature Chemistry

Exo-Selective Reductive Macrocyclization of Ynals

(2015) Hengbin Wang et al.   ORGANIC LETTERS

Structural insights into species-specific features of the ribosome from the pathogenStaphylococcus aureus

(2015) Zohar Eyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and Characterization of a New Peptide Prodrug of Glucosamine with Enhanced Gut Permeability

(2015) Hamed Gilzad Kohan et al.   PLoS One

The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

(2014) Peter M. Wright et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A click chemistry approach to pleuromutilin derivatives. Part 3: Extended footprinting analysis and excellent MRSA inhibition for a derivative with an adenine phenyl side chain

(2014) Ida Dreier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Antimicrobial Activity of the Hybrid Molecules between Sulfonamides and Active Antimicrobial Pleuromutilin Derivative

(2014) Liangzhu Chen et al.   Chemical Biology & Drug Design

Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with a Substituted Thiadiazole Moiety as Potent Drug-Resistant Bacteria Inhibitors

(2014) Ruofeng Shang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of Novel Thioether Pleuromutilin Derivatives as Potent Antibacterial Agents

(2014) Chenyu Ling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol

(2014) Kotaro Iwasaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Biological Evaluation of New Pleuromutilin Derivatives as Antibacterial Agents

(2014) Ruo-Feng Shang et al.   MOLECULES

Synthesis and synthetic chemistry of pleuromutilin

(2014) Neal J. Fazakerley et al.   TETRAHEDRON

Antimicrobial Activity of the Pleuromutilin Antibiotic BC-3781 against Bacterial Pathogens Isolated in the SENTRY Antimicrobial Surveillance Program in 2010

(2013) Susanne Paukner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Total Synthesis of (+)-Pleuromutilin

(2013) Neal J. Fazakerley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Efficient Antibacterial Agents: A Review of the Synthesis, Biological Evaluation and Mechanism of Pleuromutilin Derivatives

(2013) Ruofeng Shang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis and antibacterial evaluation of novel pleuromutilin derivatives

(2013) Ruofeng Shang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety

(2013) Ruofeng Shang et al.   PLoS One

Transferable Plasmid-Mediated Resistance to Linezolid Due tocfrin a Human Clinical Isolate of Enterococcus faecalis

(2012) Lorena Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, Synthesis, and Antibacterial Activity of Novel Pleuromutilin Derivatives Bearing an Amino Thiazolyl Ring

(2012) Yong Ling et al.   ARCHIV DER PHARMAZIE

Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies

(2012) Xinyang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The enterococcal ABC transporter gene lsa(E) confers combined resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-susceptible and methicillin-resistant Staphylococcus aureus

(2012) Sarah Wendlandt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)

(2012) H. S. Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Disk Diffusion and MIC Quality Control Ranges for BC-3205 and BC-3781, Two Novel Pleuromutilin Antibiotics

(2012) J. E. Ross et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Click Chemistry Approach to Pleuromutilin Derivatives, Part 2: Conjugates with Acyclic Nucleosides and Their Ribosomal Binding and Antibacterial Activity

(2012) Ida Dreier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic functionalization of unactivated primary C–H bonds directed by an alcohol

(2012) Eric M. Simmons et al.   NATURE

Are pleuromutilin antibiotics finally fit for human use?

(2011) Rodger Novak   Annals of the New York Academy of Sciences

New Transposon Tn6133in Methicillin-Resistant Staphylococcus aureus ST398 Containsvga(E), a Novel Streptogramin A, Pleuromutilin, and Lincosamide Resistance Gene

(2011) Sybille Schwendener et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cross-Resistance to Lincosamides, Streptogramins A, and Pleuromutilins Due to thelsa(C) Gene inStreptococcus agalactiaeUCN70

(2011) Brigitte Malbruny et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, synthesis, and structure–activity relationship studies of conformationally restricted mutilin 14-carbamates

(2011) Liqiang Fu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Detection of the novel vga(E) gene in methicillin-resistant Staphylococcus aureus CC398 isolates from cattle and poultry

(2011) T. Hauschild et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pleuromutilin and its Derivatives-The Lead Compounds for Novel Antibiotics

(2011) Y. -Z. Tang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A stereoselective, Sm(ii)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

(2011) Thomas J. K. Findley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product

(2011) Daniel P. Uccello et al.   TETRAHEDRON LETTERS

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

(2011) Stephen D. Lotesta et al.   Chemical Science

Nickel-catalyzed regiodivergent approach to macrolide motifs

(2011) Abdur-Rafay Shareef et al.   Chemical Science

A concise synthesis of the molecular framework of pleuromutilin

(2010) Junjia Liu et al.   CHEMICAL COMMUNICATIONS

Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

(2010) Li Qiang Fu et al.   CHINESE CHEMICAL LETTERS

Multicity Outbreak of Linezolid‐ResistantStaphylococcus epidermidisAssociated with Clonal Spread of acfr‐Containing Strain

(2010) Hector Bonilla et al.   CLINICAL INFECTIOUS DISEASES

Small plasmids carrying vga(A) or vga(C) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-resistant Staphylococcus aureus ST398 from swine

(2010) K. Kadlec et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation

(2010) M. S. Chen et al.   SCIENCE

Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens

(2009) Liqiang Fu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Pleuromutilin Derivatives with Excellent Antibacterial Activity AgainstStaphylococcus aureus

(2009) Peng Xu et al.   Chemical Biology & Drug Design

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P)

(2009) Dietmar W Siemann et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mutilins Derivatives: From Veterinary to Human-used Antibiotics

(2009) Changhua Hu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Iridium‐Catalyzed H/D Exchange at Vinyl Groups without Olefin Isomerization

(2008) Jianrong Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus

(2008) D. R. Gentry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pleuromutilin derivatives having a purine ring. Part 1: New compounds with promising antibacterial activity against resistant Gram-positive pathogens

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pleuromutilin derivatives having a purine ring. Part 3: Synthesis and antibacterial activity of novel compounds possessing a piperazine ring spacer

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antibacterial activities of pleuromutilin derivatives

(2008) Yuan Yuan Zhang et al.   CHINESE CHEMICAL LETTERS

A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome

(2008) Line Lolk et al.   JOURNAL OF MEDICINAL CHEMISTRY

The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

(2003) Susan M. Poulsen et al.   MOLECULAR MICROBIOLOGY