Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 8, Issue 3, Pages 317-321Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2014.01.018
Keywords
MCF 7; HeLa; EDCI; HOBt; Diamide
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Funding
- Board for Research in Nuclear Sciences, Department of Atomic Energy, Government of India
- Deanship of Scientific Research at King Saud University [RGP-VPP-207]
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Synthesis and characterization of new heterocyclic pyrazole chalcones (4a-e) and diamide (6a-e) derivatives are described. Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones. Diamides were synthesized by the reaction of phthalic acid and amines. Newly synthesized compounds were characterized by spectral studies and their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma) and HeLa (human cervical tumor cells) cell lines. Few of the synthesized molecules inhibited the growth of the human breast cancer cell lines and human cervical tumor cell lines at low micromolar to nanomolar concentrations. (C) 2014 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
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