Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 22, Issue 2, Pages 352-358Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532011000200022
Keywords
synthesis; 1-aryl-1H-pyrazole-4-carboximidamides; leishmaniasis
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Funding
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Programa de Desenvolvimento Tecnologico em Insumos para Saude (PDTIS)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal Docente (CAPES)
- Universidade Federal Fluminense (PROPP-UFF)
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Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4-carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.
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