Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders
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Title
Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders
Authors
Keywords
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Journal
MOLECULES
Volume 23, Issue 2, Pages 411
Publisher
MDPI AG
Online
2018-02-14
DOI
10.3390/molecules23020411
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- (2018) John S. Lazo et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats
- (2017) Naoki Tajiri et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1
- (2017) Fei Yi et al. JOURNAL OF VIROLOGY
- RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis
- (2017) Stephanie Devaux et al. MOLECULAR & CELLULAR PROTEOMICS
- A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish
- (2017) Sudhanshu Sahu et al. MOLECULAR NEUROBIOLOGY
- A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase
- (2017) Samantha Wellington et al. Nature Chemical Biology
- Spinal cord injury drives chronic brain changes
- (2017) Florencia Labombarda et al. Neural Regeneration Research
- Necrostatin-1 Mitigates Endoplasmic Reticulum Stress After Spinal Cord Injury
- (2017) Shuang Wang et al. NEUROCHEMICAL RESEARCH
- Small-Molecule Potentiators for Conventional Antibiotics against Staphylococcus aureus
- (2017) Arno Vermote et al. ACS Infectious Diseases
- HDAC3 inhibition ameliorates spinal cord injury by immunomodulation
- (2017) Tomoharu Kuboyama et al. Scientific Reports
- Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injury
- (2016) Qiong Wu et al. BRAIN RESEARCH
- Selective small molecule inhibitor of theMycobacterium tuberculosisfumarate hydratase reveals an allosteric regulatory site
- (2016) Monica Kasbekar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
- (2016) Johnny Habchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The potential use of histone deacetylase inhibitors in the treatment of depression
- (2016) Manabu Fuchikami et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency
- (2016) Michael Bidinosti et al. SCIENCE
- Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma
- (2016) Akihiro Fujikawa et al. Scientific Reports
- MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses
- (2016) Adam D. Bachstetter et al. PLoS One
- Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic
- (2015) Adam D Bachstetter et al. Journal of Neuroinflammation
- The Small-Molecule TrkB Agonist 7, 8-Dihydroxyflavone Decreases Hippocampal Newborn Neuron Death After Traumatic Brain Injury
- (2015) Liang Chen et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The Role of 7,8-Dihydroxyflavone in Preventing Dendrite Degeneration in Cortex After Moderate Traumatic Brain Injury
- (2015) Shu Zhao et al. MOLECULAR NEUROBIOLOGY
- A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients
- (2015) M Fava et al. MOLECULAR PSYCHIATRY
- A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
- (2015) Samuel I A Cohen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PubChem Substance and Compound databases
- (2015) Sunghwan Kim et al. NUCLEIC ACIDS RESEARCH
- A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
- (2015) Samuel I A Cohen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action
- (2015) Sumana Chakravarty et al. Scientific Reports
- Attenuation of Cell Death in Injured Cortex After Post-Traumatic Brain Injury Moderate Hypothermia: Possible Involvement of Autophagy Pathway
- (2015) Yichao Jin et al. World Neurosurgery
- Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis
- (2014) Paul C. Trippier et al. ACS Chemical Neuroscience
- A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
- (2014) Eric Karran et al. ANNALS OF NEUROLOGY
- SMTP-7, a new thrombolytic agent, decreases hemorrhagic transformation after transient middle cerebral artery occlusion under warfarin anticoagulation in mice
- (2014) Akira Ito et al. BRAIN RESEARCH
- Altered Gene Expression in an Embolic Stroke Model After Thrombolysis With Tissue Plasminogen Activator and Stachybotrys microspora Triprenyl Phenol-7
- (2014) Terumasa Hashimoto et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- TLR4 inhibitor resatorvid provides neuroprotection in experimental traumatic brain injury: Implication in the treatment of human brain injury
- (2014) Dingding Zhang et al. NEUROCHEMISTRY INTERNATIONAL
- Tegaserod, a small compound mimetic of polysialic acid, promotes functional recovery after spinal cord injury in mice
- (2014) H.-C. Pan et al. NEUROSCIENCE
- Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated -synuclein
- (2014) M. Oh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule inhibitors of HCV replication from Pomegranate
- (2014) B. Uma Reddy et al. Scientific Reports
- Targeting GTPases in Parkinson’s disease: comparison to the historic path of kinase drug discovery and perspectives
- (2014) Lin Hong et al. Frontiers in Molecular Neuroscience
- Neurotrophic Natural Products: Chemistry and Biology
- (2013) Jing Xu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
- (2013) Nicholas T. Hertz et al. CELL
- PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
- (2013) G Arena et al. CELL DEATH AND DIFFERENTIATION
- A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS
- (2013) Yin M. Yang et al. Cell Stem Cell
- IlliciumSesquiterpenes: Divergent Synthetic Strategy and Neurotrophic Activity Studies
- (2013) Lynnie Trzoss et al. CHEMISTRY-A EUROPEAN JOURNAL
- A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury
- (2013) Kelli G. Sharp et al. EXPERIMENTAL NEUROLOGY
- Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats
- (2013) Elena Redondo-Castro et al. EXPERIMENTAL NEUROLOGY
- Recent progress in the discovery of small-molecule inhibitors of the HMT EZH2 for the treatment of cancer
- (2013) Sharad K Verma et al. Future Medicinal Chemistry
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- (2013) Michel Weïwer et al. Future Medicinal Chemistry
- SMTP-7, a Novel Small-Molecule Thrombolytic for Ischemic Stroke: A Study in Rodents and Primates
- (2013) Hironobu Sawada et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
- (2013) C. Tep et al. JOURNAL OF NEUROSCIENCE
- Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: A New Target of Disease Mechanisms
- (2013) Lee J. Martin et al. Neurotherapeutics
- Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism
- (2013) S. I. A. Cohen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia
- (2012) Peder Buchhave ARCHIVES OF GENERAL PSYCHIATRY
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- (2012) Jodi Nunnari et al. CELL
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- (2012) M. A. Kopp et al. CELL AND TISSUE RESEARCH
- Mitochondrial quality control: a matter of life and death for neurons
- (2012) Elena I Rugarli et al. EMBO JOURNAL
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- (2012) Takuya Kanno et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2012) Ernesto Miquel et al. PLoS One
- Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy
- (2012) Amanda J. Law et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
- (2012) C. Kondapalli et al. Open Biology
- NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease
- (2011) Dong-Hee Choi et al. ANTIOXIDANTS & REDOX SIGNALING
- PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia
- (2011) Jan Kehler et al. CURRENT PHARMACEUTICAL DESIGN
- Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis
- (2011) Kazunori Tanaka et al. EXPERIMENTAL NEUROLOGY
- RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury
- (2011) Bin Xing et al. EXPERIMENTAL NEUROLOGY
- Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis
- (2011) Young-Eun Yoo et al. EXPERIMENTAL NEUROLOGY
- Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
- (2011) Arie Neymotin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats
- (2011) Guo-Hua Wang et al. JOURNAL OF NEUROTRAUMA
- SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments
- (2011) Peter I. Joyce et al. MAMMALIAN GENOME
- Distinct Effects of Tissue-Type Plasminogen Activator and SMTP-7 on Cerebrovascular Inflammation Following Thrombolytic Reperfusion
- (2011) Takuro Miyazaki et al. STROKE
- Calcium dysregulation in amyotrophic lateral sclerosis
- (2010) Julian Grosskreutz et al. CELL CALCIUM
- Two Functions, One Molecule: A Metal-Binding and a Targeting Moiety to Combat Alzheimer's Disease
- (2010) Christelle Hureau et al. CHEMBIOCHEM
- Histone Deacetylases and Mood Disorders: Epigenetic Programming in Gene-Environment Interactions
- (2010) Rodrigo Machado-Vieira et al. CNS Neuroscience & Therapeutics
- Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems
- (2010) Keiji Hasumi et al. FEBS Journal
- Neuroprotective Properties of Mildronate, a Small Molecule, in a Rat Model of Parkinson’s Disease
- (2010) Vija Z. Klusa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Molecular Mechanism for Ibuprofen-Mediated RhoA Inhibition in Neurons
- (2010) J. Dill et al. JOURNAL OF NEUROSCIENCE
- A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice
- (2010) Keita Shibata et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Calpastatin reduces toxicity of SOD1G93A in a culture model of amyotrophic lateral sclerosis
- (2010) Miranda L. Tradewell et al. NEUROREPORT
- Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies
- (2010) David J. Loane et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
- (2009) Adam K. Walker et al. BRAIN
- Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease
- (2009) Lauren E. Scott et al. CHEMICAL REVIEWS
- The chemistry of Alzheimer’s disease
- (2009) Arvi Rauk CHEMICAL SOCIETY REVIEWS
- Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
- (2009) I. Niebroj-Dobosz et al. EUROPEAN JOURNAL OF NEUROLOGY
- Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia
- (2009) Peixiong Yuan et al. JOURNAL OF AFFECTIVE DISORDERS
- Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
- (2009) Hristelina Ilieva et al. JOURNAL OF CELL BIOLOGY
- Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth
- (2009) Xingxing Wang et al. JOURNAL OF NEUROTRAUMA
- Small Molecule Modulators of Copper-Induced Aβ Aggregation
- (2009) Sarmad S. Hindo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Neuroprotective properties of mildronate, a mitochondria-targeted small molecule
- (2009) Jolanta Pupure et al. NEUROSCIENCE LETTERS
- Alzheimer's disease, metal ions and metal homeostatic therapy
- (2009) Paolo Zatta et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Metals in Alzheimer's and Parkinson's Diseases
- (2008) Kevin J Barnham et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury
- (2008) Feng Bao et al. EXPERIMENTAL NEUROLOGY
- A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice
- (2008) Kazunori Tanaka et al. EXPERIMENTAL NEUROLOGY
- Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents
- (2008) Wei-hui Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition
- (2008) Y. Leng et al. JOURNAL OF NEUROSCIENCE
- Small-Molecule Protein Tyrosine Phosphatase Inhibition as a Neuroprotective Treatment after Spinal Cord Injury in Adult Rats
- (2008) S. Nakashima et al. JOURNAL OF NEUROSCIENCE
- Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection
- (2008) B. Langley et al. JOURNAL OF NEUROSCIENCE
- Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
- (2008) Lars Lannfelt et al. LANCET NEUROLOGY
- Small-molecule catalysis
- (2008) Andrew Mitchinson et al. NATURE
- Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
- (2008) Paul A. Adlard et al. NEURON
- Therapeutics for Alzheimer’s disease based on the metal hypothesis
- (2008) Ashley I. Bush et al. Neurotherapeutics
- National US Estimates of Recombinant Tissue Plasminogen Activator Use
- (2008) Dawn Kleindorfer et al. STROKE
- Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection
- (2007) Rajiv P. Sharma et al. SCHIZOPHRENIA RESEARCH
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