SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

(2010) Brian C. Kraemer et al.   ACTA NEUROPATHOLOGICA

Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents

(2010) C. F. Meehan et al.   Acta Physiologica

Aggregation modulating elements in mutant human superoxide dismutase 1

(2010) Celeste M. Karch et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ultrastructural diversity of inclusions and aggregations in the lumbar spinal cord of SOD1-G93A transgenic mice

(2010) Yansu Guo et al.   BRAIN RESEARCH

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

(2010) T. Ramesh et al.   Disease Models & Mechanisms

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice

(2010) A. Florence Keller et al.   EXPERIMENTAL NEUROLOGY

Decreased GLT-1 and increased SOD1 and HO-1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1-G93A transgenic mice

(2010) Yansu Guo et al.   FEBS LETTERS

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

(2010) Margaret Wong et al.   HUMAN MOLECULAR GENETICS

The unfolded protein response in familial amyotrophic lateral sclerosis

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Neurotoxic effects of TDP-43 overexpression in C. elegans

(2010) Peter E.A. Ash et al.   HUMAN MOLECULAR GENETICS

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

(2010) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity

(2010) Alberto Ferri et al.   HUMAN MOLECULAR GENETICS

Ubiquilin Modifies TDP-43 Toxicity in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

(2010) Keith A. Hanson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

(2010) Nichole A. Reyes et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U

(2010) Kuen-Jer Tsai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS

(2010) Samer Abou Ezzi et al.   JOURNAL OF NEUROCHEMISTRY

Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis

(2010) Marco Milanese et al.   JOURNAL OF NEUROCHEMISTRY

Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models

(2010) Eun Jin Yang et al.   Journal of Neuroinflammation

Monitoring systemic oxidative stress in an animal model of amyotrophic lateral sclerosis

(2010) Francisco Javier Miana-Mena et al.   JOURNAL OF NEUROLOGY

Induction of Protective Immunity by Vaccination With Wild-Type Apo Superoxide Dismutase 1 in Mutant SOD1 Transgenic Mice

(2010) Shigeko Takeuchi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy

(2010) N. F. Liachko et al.   JOURNAL OF NEUROSCIENCE

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS

(2010) Farhad Ghoddoussi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2010) Swati P Aggarwal et al.   LANCET NEUROLOGY

Mitochondrial dysfunction and intracellular calcium dysregulation in ALS

(2010) Hibiki Kawamata et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial fission/fusion dynamics and apoptosis

(2010) Clare Sheridan et al.   MITOCHONDRION

Excitability properties of mouse motor axons in the mutant SOD1G93A model of amyotrophic lateral sclerosis

(2010) Delphine Boërio et al.   MUSCLE & NERVE

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

(2010) Andrew C. Elden et al.   NATURE

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis

(2010) John M Lincecum et al.   NATURE GENETICS

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Progressive motor weakness in transgenic mice expressing human TDP-43

(2010) Nancy R. Stallings et al.   NEUROBIOLOGY OF DISEASE

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies

(2010) Laetitia Miguel et al.   NEUROBIOLOGY OF DISEASE

TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology

(2010) Iga Wegorzewska et al.   Neurodegenerative Diseases

Lithium carbonate in amyotrophic lateral sclerosis: Lack of efficacy in a dose-finding trial

(2010) A. Chio et al.   NEUROLOGY

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis

(2010) Ruth Chia et al.   PLoS One

TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity

(2010) Aaron Voigt et al.   PLoS One

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

(2010) Angela S. Laird et al.   PLoS One

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Drosophila model for TDP-43 proteinopathy

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

(2010) P.-M. Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice

(2010) X. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

(2010) Hans Wils et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canine Degenerative Myelopathy

(2010) Joan R. Coates et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene

(2010) Hongxia Zhou et al.   PLoS Genetics

Toward more efficient clinical trials for amyotrophic lateral sclerosis

(2009) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis

(2009) Sanne Piepers et al.   ANNALS OF NEUROLOGY

A Role for Copper in the Toxicity of Zinc-Deficient Superoxide Dismutase to Motor Neurons in Amyotrophic Lateral Sclerosis

(2009) Kari A. Trumbull et al.   ANTIOXIDANTS & REDOX SIGNALING

Axonal Mitochondrial Clusters Containing Mutant SOD1 in Transgenic Models of ALS

(2009) Jose R. Sotelo-Silveira et al.   ANTIOXIDANTS & REDOX SIGNALING

Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis

(2009) Shizuo Ohnishi et al.   BRAIN RESEARCH

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

(2009) Kathryn Volkening et al.   BRAIN RESEARCH

Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration

(2009) J. Simon Lunn et al.   Developmental Neurobiology

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

(2009) Fabienne C Fiesel et al.   EMBO JOURNAL

Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2009) Yan-Su Guo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Lenalidomide (Revlimid®) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis

(2009) Arie Neymotin et al.   EXPERIMENTAL NEUROLOGY

Depletion of TDP-43 affectsDrosophila motoneuronsterminal synapsis and locomotive behavior

(2009) Fabian Feiguin et al.   FEBS LETTERS

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

(2009) B. J. Turner et al.   HUMAN MOLECULAR GENETICS

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

(2009) Edor Kabashi et al.   HUMAN MOLECULAR GENETICS

Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse

(2009) L. Wang et al.   HUMAN MOLECULAR GENETICS

Hyperactive Intracellular Calcium Signaling Associated with Localized Mitochondrial Defects in Skeletal Muscle of an Animal Model of Amyotrophic Lateral Sclerosis

(2009) Jingsong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development

(2009) Chantelle F. Sephton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Early Excitability Changes in Lumbar Motoneurons of Transgenic SOD1G85R and SOD1G93A-Low Mice

(2009) Arnaud Pambo-Pambo et al.   JOURNAL OF NEUROPHYSIOLOGY

Progressive Changes in Synaptic Inputs to Motoneurons in Adult Sacral Spinal Cord of a Mouse Model of Amyotrophic Lateral Sclerosis

(2009) M. Jiang et al.   JOURNAL OF NEUROSCIENCE

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis

(2009) Jun Sone et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)

(2009) Michael J. Strong   JOURNAL OF THE NEUROLOGICAL SCIENCES

Dynamic NAD(P)H post-synaptic autofluorescence signals for the assessment of mitochondrial function in a neurodegenerative disease: Monitoring the primary motor cortex of G93A mice, an amyotrophic lateral sclerosis model

(2009) Stefano Loizzo et al.   MITOCHONDRION

Changes in the Spinal Cord Proteome of an Amyotrophic Lateral Sclerosis Murine Model Determined by Differential In-gel Electrophoresis

(2009) Daniel Bergemalm et al.   MOLECULAR & CELLULAR PROTEOMICS

Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice

(2009) Hanna Wootz et al.   NEUROBIOLOGY OF DISEASE

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

(2009) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association analysis reveals aSOD1mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

(2009) Tomoyuki Awano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching

(2009) Yubing Lu et al.   Molecular Brain

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease

(2008) Richard W. Orrell et al.   Amyotrophic Lateral Sclerosis

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

TDP-43mutation in familial amyotrophic lateral sclerosis

(2008) Akio Yokoseki et al.   ANNALS OF NEUROLOGY

The prostaglandin E2EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

(2008) Xibin Liang et al.   ANNALS OF NEUROLOGY

TDP-43A315T mutation in familial motor neuron disease

(2008) Michael A. Gitcho et al.   ANNALS OF NEUROLOGY

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis

(2008) Claudia Pitzer et al.   BRAIN

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

(2008) Maria C.N. Marchetto et al.   Cell Stem Cell

KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the Treatment of Amyotrophic Lateral Sclerosis

(2008) Valentin K. Gribkoff et al.   CNS Neuroscience & Therapeutics

GABAAreceptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis

(2008) Irene Carunchio et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

(2008) Eiichi Tokuda et al.   EXPERIMENTAL NEUROLOGY

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

(2008) Hidefumi Ito et al.   EXPERIMENTAL NEUROLOGY

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice

(2008) Kazunori Tanaka et al.   EXPERIMENTAL NEUROLOGY

Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1G93A mice

(2008) Joanna Riddoch-Contreras et al.   EXPERIMENTAL NEUROLOGY

Molecular dissection of ALS-associated toxicity of SOD1 in transgenic mice using an exon-fusion approach

(2008) Deng Han-Xiang et al.   HUMAN MOLECULAR GENETICS

Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS

(2008) Jody B. Proescher et al.   HUMAN MOLECULAR GENETICS

Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration

(2008) Claire L. Simpson et al.   HUMAN MOLECULAR GENETICS

A Limited Role for Disulfide Cross-linking in the Aggregation of Mutant SOD1 Linked to Familial Amyotrophic Lateral Sclerosis

(2008) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADrosophilaModel for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1

(2008) Melanie R. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of mutant SOD1G93Ain astrocytes induces functional deficits in motoneuron mitochondria

(2008) Lynsey G. Bilsland et al.   JOURNAL OF NEUROCHEMISTRY

Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

(2008) Bernadett Kalmar et al.   JOURNAL OF NEUROCHEMISTRY

Motor Neuron Regeneration in Adult Zebrafish

(2008) M. M. Reimer et al.   JOURNAL OF NEUROSCIENCE

Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

(2008) D. Jaarsma et al.   JOURNAL OF NEUROSCIENCE

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

(2008) G. Gowing et al.   JOURNAL OF NEUROSCIENCE

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

(2008) B. van Zundert et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

(2008) Vivianna M Van Deerlin et al.   LANCET NEUROLOGY

Cu/Zn Superoxide Dismutase Typical for Familial Amyotrophic Lateral Sclerosis Increases the Vulnerability of Mitochondria and Perturbs Ca2+ Homeostasis in SOD1G93A Mice

(2008) M. K. Jaiswal et al.   MOLECULAR PHARMACOLOGY

Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice

(2008) Chris Towne et al.   MOLECULAR THERAPY

Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis

(2008) Merit E. Cudkowicz et al.   MUSCLE & NERVE

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

(2008) Angelo C Lepore et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE

CLINICAL, ELECTROPHYSIOLOGIC, AND PATHOLOGIC EVIDENCE FOR SENSORY ABNORMALITIES IN ALS

(2008) G. Amoiridis et al.   NEUROLOGY

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

(2008) E. J. Sorenson et al.   NEUROLOGY

Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1G93A–transgenic mice

(2008) G. Rohde et al.   NEUROSCIENCE

VEGF and ALS

(2008) Sivakumar Sathasivam   NEUROSCIENCE RESEARCH

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

(2008) Yueming Chang et al.   PLoS One

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Up-Regulation of Insulin-Like Growth Factor-II Receptor in Reactive Astrocytes in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Rats

(2008) Byambasuren Dagvajantsan et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice

(2007) Chan-Il Choi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

(2007) Paul S. Sharp et al.   NEUROBIOLOGY OF DISEASE