SMTP-7, a Novel Small-Molecule Thrombolytic for Ischemic Stroke: A Study in Rodents and Primates

A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke

(2012) Mark Parsons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice

(2011) Keita Shibata et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain

(2011) Yosuke Akamatsu et al.   NEUROSCIENCE LETTERS

Distinct Effects of Tissue-Type Plasminogen Activator and SMTP-7 on Cerebrovascular Inflammation Following Thrombolytic Reperfusion

(2011) Takuro Miyazaki et al.   STROKE

Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems

(2010) Keiji Hasumi et al.   FEBS Journal

A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite

(2010) Terumasa Hashimoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice

(2010) Keita Shibata et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study

(2008) Werner Hacke et al.   LANCET NEUROLOGY

National US Estimates of Recombinant Tissue Plasminogen Activator Use

(2008) Dawn Kleindorfer et al.   STROKE

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

(2008) Manuel Yepes et al.   TRENDS IN NEUROSCIENCES