Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases

CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis

(2017) Hiroshi Matsuno et al.   INFLAMMATORY BOWEL DISEASES

Diversity and functions of intestinal mononuclear phagocytes

(2017) T Joeris et al.   Mucosal Immunology

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Role of Monocytes and Intestinal Macrophages in Crohnʼs Disease and Ulcerative Colitis

(2016) Susanne T. Gren et al.   INFLAMMATORY BOWEL DISEASES

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

(2016) T M Fenton et al.   Mucosal Immunology

Age-related alterations in blood and colonic dendritic cell properties

(2016) Rakesh Vora et al.   Oncotarget

slan-defined subsets of CD16-positive monocytes: impact of granulomatous inflammation and M-CSF receptor mutation

(2015) T. P. Hofer et al.   BLOOD

Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum

(2015) Elizabeth R Mann et al.   GUT

Human blood CD1c dendritic cells stimulate IL-12-independent IFN-γ responses and have a strikingly low inflammatory profile

(2015) Adel Benlahrech et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn's versus ulcerative colitis patients

(2015) M. Bsat et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation

(2015) M K Magnusson et al.   Mucosal Immunology

A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System

(2015) Martin Guilliams et al.   Frontiers in Immunology

Human and Mouse Mononuclear Phagocyte Networks: A Tale of Two Species?

(2015) Gary Reynolds et al.   Frontiers in Immunology

Increased Production of Retinoic Acid by Intestinal Macrophages Contributes to Their Inflammatory Phenotype in Patients With Crohn's Disease

(2014) Theodore J. Sanders et al.   GASTROENTEROLOGY

miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD

(2014) Wei Wu et al.   GUT

Pattern Recognition Receptor Signaling in Human Dendritic Cells is Enhanced by ICOS Ligand and Modulated by the Crohn’s Disease ICOSLG Risk Allele

(2014) Matija Hedl et al.   IMMUNITY

Macrophages in intestinal homeostasis and inflammation

(2014) Calum C. Bain et al.   IMMUNOLOGICAL REVIEWS

Intestinal dendritic cells in the regulation of mucosal immunity

(2014) Vasileios Bekiaris et al.   IMMUNOLOGICAL REVIEWS

Innate Immune Factors in the Development and Maintenance of Pouchitis

(2014) Jonathan Landy et al.   INFLAMMATORY BOWEL DISEASES

Human Gut Dendritic Cells Drive Aberrant Gut-specific T-cell Responses in Ulcerative Colitis, Characterized by Increased IL-4 Production and Loss of IL-22 and IFNγ

(2014) Elizabeth R. Mann et al.   INFLAMMATORY BOWEL DISEASES

Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells

(2014) I Vicente-Suarez et al.   Mucosal Immunology

CCR2+CD103− intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells

(2014) C L Scott et al.   Mucosal Immunology

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Intestinal macrophages and dendritic cells: what's the difference?

(2014) Vuk Cerovic et al.   TRENDS IN IMMUNOLOGY

Blood dendritic cells: “canary in the coal mine” to predict chronic inflammatory disease?

(2014) Brodie Miles et al.   Frontiers in Microbiology

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Lost therapeutic potential of monocyte-derived dendritic cells through lost tissue homing: stable restoration of gut specificity with retinoic acid

(2013) D. Bernardo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Organization of the mouse and human DC network

(2013) Andreas Schlitzer et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function

(2013) Emma K. Persson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased Th17-Inducing Activity of CD14+ CD163low Myeloid Cells in Intestinal Lamina Propria of Patients With Crohn’s Disease

(2013) Takayuki Ogino et al.   GASTROENTEROLOGY

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

Human dendritic cell subsets

(2013) Matthew Collin et al.   IMMUNOLOGY

Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men

(2013) Elizabeth R. Mann et al.   IMMUNOLOGY LETTERS

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic StrainLactobacillus caseiShirota

(2013) Elizabeth R. Mann et al.   MEDIATORS OF INFLAMMATION

Altered human gut dendritic cell properties in ulcerative colitis are reversed byLactobacillus plantarumextracellular encrypted peptide STp

(2013) Hafid O. Al-Hassi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

Dendritic Cells from Crohn’s Disease Patients Show Aberrant STAT1 and STAT3 Signaling

(2013) Janne K. Nieminen et al.   PLoS One

Human intestinal dendritic cells as controllers of mucosal immunity

(2013) David Bernardo   REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and Tcells they stimulate

(2012) David Bernardo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells

(2012) John J. Worthington et al.   IMMUNOBIOLOGY

Enumeration of human peripheral blood dendritic cells throughout the life

(2012) G. Orsini et al.   INTERNATIONAL IMMUNOLOGY

Homing marker expression on circulating dendritic cells correlates with different phenotypes of Crohn's disease

(2012) Simon T. Peake et al.   Journal of Crohns & Colitis

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn’s disease

(2012) H O Al-Hassi et al.   Mucosal Immunology

Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells

(2012) V Cerovic et al.   Mucosal Immunology

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Effect of age on surface molecules and cytokine expression in human dendritic cells

(2011) Antonio Ciaramella et al.   CELLULAR IMMUNOLOGY

Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis

(2011) D. C. Baumgart et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Human Gut-Specific Homeostatic Dendritic Cells Are Generated from Blood Precursors by the Gut Microenvironment

(2011) Elizabeth R. Mann et al.   INFLAMMATORY BOWEL DISEASES

Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

(2011) T. L. Denning et al.   JOURNAL OF IMMUNOLOGY

Mucosal Macrophages in Intestinal Homeostasis and Inflammation

(2011) Allan McI Mowat et al.   Journal of Innate Immunity

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

(2011) Pin-Yu Perera et al.   MICROBES AND INFECTION

Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells

(2011) E Jaensson-Gyllenbäck et al.   Mucosal Immunology

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer

(2011) Adriana J. Michielsen et al.   PLoS One

Intestinal CD103+ dendritic cells: master regulators of tolerance?

(2011) Charlotte L. Scott et al.   TRENDS IN IMMUNOLOGY

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

(2011) William W. Agace et al.   TRENDS IN IMMUNOLOGY

Impact of aging on dendritic cell functions in humans

(2010) Anshu Agrawal et al.   AGEING RESEARCH REVIEWS

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis

(2010) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Homing of immune cells: Role in homeostasis and intestinal inflammation

(2010) Ailsa L. Hart et al.   INFLAMMATORY BOWEL DISEASES

Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohnʼs disease

(2010) S. C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Human Intestinal Lamina Propria CD1c+ Dendritic Cells Display an Activated Phenotype at Steady State and Produce IL-23 in Response to TLR7/8 Stimulation

(2010) S. M. Dillon et al.   JOURNAL OF IMMUNOLOGY

Epithelial crosstalk at the microbiota-mucosal interface

(2010) J. M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease

(2009) D. C. Baumgart et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Salmonella Induces Flagellin- and MyD88-Dependent Migration of Bacteria-Capturing Dendritic Cells Into the Gut Lumen

(2009) Juan L. Arques et al.   GASTROENTEROLOGY

How intestinal epithelial cells tolerise dendritic cells and its relevance to inflammatory bowel disease

(2009) M Shale et al.   GUT

Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells

(2009) I D Iliev et al.   GUT

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

(2009) Chen Varol et al.   IMMUNITY

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD

(2009) Alberto J. León et al.   MEDIATORS OF INFLAMMATION

Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning

(2009) I D Iliev et al.   Mucosal Immunology

Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors

(2008) Szilvia Benkő et al.   BIOLOGICAL CHEMISTRY

Central role of dendritic cells in the regulation and deregulation of immune responses

(2008) F. Granucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mucosal macrophages and the regulation of immune responses in the intestine

(2008) Andrew M. Platt et al.   IMMUNOLOGY LETTERS

Small intestinal CD103+dendritic cells display unique functional properties that are conserved between mice and humans

(2008) Elin Jaensson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vitamin A rewrites the ABCs of oral tolerance

(2008) W Strober   Mucosal Immunology

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

(2008) Hekla Sigmundsdottir et al.   NATURE IMMUNOLOGY