Review
Biochemistry & Molecular Biology
Andrea Padoan, Giulia Musso, Nicole Contran, Daniela Basso
Summary: The role of innate and adaptive immunity in the pathogenesis of inflammatory bowel diseases (IBD) is discussed. Altered innate immunity with increased Th17 and decreased Treg cells, along with an imbalance of inflammatory and anti-inflammatory cytokines, contribute to persistent gut mucosal inflammation. The activation of inflammasomes by exogenous or endogenous triggers, favored by mutations of NOD and NLRP proteins, highlights the role of autoinflammation in IBD. Autoimmunity mechanisms, triggered by bacterial antigens and antigens derived from intestinal cell degradation, lead to the production of antibodies and autoantibodies, further contributing to the pathogenesis of IBD. Inflammation, autoinflammation, and autoimmunity collectively disrupt the mucus layer and increase intestinal permeability, perpetuating mucosal inflammation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aws Sadik, Christina Dardani, Panagiota Pagoni, Alexandra Havdahl, Evie Stergiakouli, Golam M. Khandaker, Sarah A. Sullivan, Stan Zammit, Hannah J. Jones, George Davey Smith, Christina Dalman, Hakan Karlsson, Renee M. Gardner, Dheeraj Rai
Summary: Evidence from multiple studies indicates a potential causal link between parental inflammatory bowel disease and autism in children. These studies utilized various methodologies and datasets to establish this association.
Review
Pharmacology & Pharmacy
Hajime Honjo, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Summary: Inflammatory bowel diseases (IBDs) are increasing worldwide, with many patients showing refractoriness to current treatments. Therefore, the search for novel therapeutic targets, such as RIPK2, is crucial. Experimental and clinical studies have implicated RIPK2 in the development of autoimmune diseases, particularly IBD, suggesting its potential as a new therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Niusha Sharifinejad, Elaheh Mahmoudi
Summary: Inflammatory bowel disease is an immune-mediated inflammatory condition, and recent research has highlighted the role of intestinal fungal flora and immune pathways in its pathogenesis.
GASTROENTEROLOGY REPORT
(2023)
Article
Dentistry, Oral Surgery & Medicine
Buket Acar, Ersin Gumus, Selcen Ozcan-Bulut, Cansu Ozsin-Ozler, Meryem Seda Boyraz, Cagman Tan, Ismail Yaz, Begum Ozbek, Deniz Cagdas, Inci Nur Saltik-Temizel, Hulya Demir, Hasan Ozen, Erdem Karabulut, Ilhan Tezcan, Aysel Yuce, Ezel Berker
Summary: The cytokine profile in gingival crevicular fluid and serum of pediatric inflammatory bowel disease (IBD) patients was evaluated, with 50 IBD patients and 21 healthy children enrolled in the study. Patients with IBD were categorized into subgroups based on disease activity and response to treatment, and the levels of pro- and anti-inflammatory cytokines were measured. Results showed that disease activity might impact gingival inflammation in pediatric patients with IBD due to increased cytokine interactions and severity of inflammation.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Grzegorz Chmielewski, Michal S. Majewski, Jakub Kuna, Mateusz Mikiewicz, Magdalena Krajewska-Wlodarczyk
Summary: Fatigue is a common symptom in various rheumatic diseases, affecting patients' quality of life and exacerbating disability. Its nature involves multiple factors, including physiological, psychological, and social aspects. Despite its significance, fatigue is often underestimated in clinical practice. Comprehensive assessment of the subjective components of fatigue is crucial for effective management of this symptom in inflammatory joint diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Anja Schulz-Kuhnt, Markus F. Neurath, Stefan Wirtz, Imke Atreya
Summary: The occurrence of epithelial defects in the gut contributes to the pathogenesis of IBD, with intestinal epithelial barrier integrity impairment being a primary trigger and consequence of chronic inflammation. Immune cells and their secretome play critical roles in altering IEC function in IBD. Recent attention has focused on ILCs, specifically their impact on IEC survival, differentiation, and barrier function, suggesting potential therapeutic targets for maintaining epithelial integrity and promoting mucosal healing in IBD.
FRONTIERS IN MEDICINE
(2021)
Letter
Gastroenterology & Hepatology
Neasa Mc Gettigan, Aoibhlinn O'Toole, Karen Boland
Summary: Exercise-induced changes in the microbiome and immunometabolic pathways show promise as a therapeutic approach for treating inflammatory bowel diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Immunology
Shin Morizane, Tomoyuki Mukai, Ko Sunagawa, Kota Tachibana, Yoshio Kawakami, Mamoru Ouchida
Summary: This review aims to provide a foundation of knowledge on the cytokines recognized or produced by epidermal keratinocytes, deepening our understanding of the role of cytokines in inflammatory skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Dziabowska-Grabias, Malgorzata Sztanke, Przemyslaw Zajac, Michal Celejewski, Katarzyna Kurek, Stanislaw Szkutnicki, Patryk Korga, Wlodzimierz Bulikowski, Krzysztof Sztanke
Summary: Inflammatory bowel diseases (IBD) are chronic, incurable diseases of the digestive tract with unclear etiology, resulting in significant impact on patients' quality of life. The incidence and prevalence of IBD are continuously increasing worldwide, becoming a significant public health burden. Current pharmaceutical management options often have side effects and may not provide sufficient disease control, leading to research on antioxidant and anti-inflammatory substances as potential treatment options.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Review
Pharmacology & Pharmacy
Xuhui Tong, Yuanyuan Zheng, Yu Li, Yongjian Xiong, Dapeng Chen
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal condition characterized by persistent inflammation, with targeting of cytokines showing efficacy in treatment. Soluble ligands as drug targets are gaining importance, being more accessible compared to receptors, and presenting opportunities for intervention in IBD treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
Summary: This study aimed to evaluate the levels of cytokines in saliva and gingival crevicular fluid (GCF) in patients with ulcerative colitis (UC), Crohn disease (CD), and non-IBD, and analyze their associations with periodontal conditions. The study found that UC and CD patients with periodontitis and gingivitis had higher levels of TNF-alpha and lower levels of IL-10 compared to non-IBD patients. Additionally, UC patients with periodontitis had higher scores of bleeding on probing and increased levels of IL-1 beta in saliva and GCF compared to CD patients. The study concluded that in the presence of periodontal diseases, UC and CD patients showed different expression levels of TNF-alpha, IL-1 beta, and IL-10 in oral secretions compared to non-IBD patients.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Chemistry, Medicinal
Yijie Song, Man Yuan, Yu Xu, Hongxi Xu
Summary: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders caused by abnormal immune response. The development of proinflammatory cytokine therapeutic agents, including TNF inhibitors, shows promise for treating IBD. Antagonizing other cytokines has shown advantages in clinical trials and can be used to target anti-TNF therapy failure. Additionally, blocking lymphocyte homing helps alleviate inflammation and tissue damage.
Article
Allergy
Shunya Mashiko, Salim Bouguermouh, Manuel Rubio, Nobuyasu Baba, Robert Bissonnette, Marika Sarfati
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Abderrahim Naji, Basilua Andre Muzembo, Ken-ichi Yagyu, Nobuyasu Baba, Frederic Deschaseaux, Luc Sensebe, Narufumi Suganuma
SCIENTIFIC REPORTS
(2016)
Article
Cell & Tissue Engineering
Abderrahim Naji, Narufumi Suganuma, Nicolas Espagnolle, Ken-ichi Yagyu, Nobuyasu Baba, Luc Sense, Frederic Deschaseaux
STEM CELLS TRANSLATIONAL MEDICINE
(2017)
Article
Cell & Tissue Engineering
Feifei Wang, Nobuyasu Baba, Yuan Shen, Tatsuyuki Yamashita, Emi Tsuru, Masayuki Tsuda, Nagamasa Maeda, Yusuke Sagara
STEM CELL RESEARCH & THERAPY
(2017)
Article
Hematology
Keiko Wakahara, Nobuyasu Baba, Vu Quang Van, Philippe Begin, Manuel Rubio, Pasquale Ferraro, Benoit Panzini, Ramses Wassef, Raymond Lahaie, Yves Caussignac, Raja Tamaz, Carole Richard, Genevieve Soucy, Guy Delespesse, Marika Sarfati
Article
Immunology
Nobuyasu Baba, Manuel Rubio, Linda Kenins, Camille Regairaz, Maximilian Woisetschlager, Jose M. Carballido, Marika Sarfati
Article
Immunology
Nobuyasu Baba, Manuel Rubio, Marika Sarfati
INTERNATIONAL IMMUNOLOGY
(2010)
Letter
Allergy
Laurence Chapuy, Marwa Bsat, Heena Mehta, Manuel Rubio, Keiko Wakahara, Vu Quang Van, Nobuyasu Baba, Cheolho Cheong, Tae Jin Yun, Benoit Panzini, Ramses Wassef, Carole Richard, Raja Tamaz, Genevieve Soucy, Guy Delespesse, Marika Sarfati
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2014)
Article
Immunology
Nobuyasu Baba, Vu Quang Van, Keiko Wakahara, Manuel Rubio, Genevieve Fortin, Benoit Panzini, Genevieve Soucy, Ramses Wassef, Carole Richard, Raja Tamaz, Raymond Lahaie, Edmond-Jean Bernard, Yves Caussignac, Raymond Leduc, Rasmy Lougnarath, Carole Bergeron, Marc-Andre Racicot, Fanny Bergeron, Marie-Andree Panzini, Pieter Demetter, Denis Franchimont, Knut Schakel, Gisbert Weckbecker, Frank Kolbinger, Christoph Heusser, Thomas Huber, Karl Welzenbach, Marika Sarfati
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Immunology
Vu Quang Van, Marianne Raymond, Nobuyasu Baba, Manuel Rubio, Keiko Wakahara, Santos A. Susin, Marika Sarfati
JOURNAL OF IMMUNOLOGY
(2012)
Article
Obstetrics & Gynecology
Feifei Wang, Yuan Shen, Emi Tsuru, Tatsuyuki Yamashita, Nobuyasu Baba, Masayuki Tsuda, Nagamasa Maeda, Yusuke Sagara
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2015)
Article
Multidisciplinary Sciences
Vu Quang Van, Nobuyasu Baba, Manuel Rubio, Keiko Wakahara, Benoit Panzini, Carole Richard, Genevieve Soucy, Denis Franchimont, Genevieve Fortin, Ana Carolina Martinez Torres, Lauriane Cabon, Santos Susin, Marika Sarfati
Article
Multidisciplinary Sciences
Nobuyasu Baba, Feifei Wang, Michiro Iizuka, Yuan Shen, Tatsuyuki Yamashita, Kimiko Takaishi, Emi Tsuru, Sachio Matsushima, Mitsuhiko Miyamura, Mikiya Fujieda, Masayuki Tsuda, Yusuke Sagara, Nagamasa Maeda
Meeting Abstract
Immunology
Vu Quang Van, Nobuyasu Baba, Manuel Rubio, Keiko Wakahara, Benoit Panzini, Carole Richard, Genevieve Susin, Denis Franchimont, Genevieve Fortin, Ana Carolina Martinez Torres, Lauriane Cabon, Santos Susin, Marika Sarfati
JOURNAL OF IMMUNOLOGY
(2012)