Article
Oncology
Yu-Fen Tsai, Leong-Perng Chan, Yuk-Kwan Chen, Chang-Wei Su, Ching-Wei Hsu, Yen-Yun Wang, Shyng-Shiou F. Yuan
Summary: RAD51 overexpression in oral squamous cell carcinoma is associated with poor prognosis and resistance to chemotherapy and radiotherapy. RAD51 overexpression promotes tumorsphere formation ability in oral cancer cells. Combination treatment of RAD51 inhibitor B02 and cisplatin enhances cytotoxicity in oral cancer cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Genetics & Heredity
Basudeb Das, Neha Jain, Bibekanand Mallick
Summary: A potential oncogene RRM2 associated with soft tissue sarcoma prognosis was identified, with high RRM2 expression linked to lower survival rates in patients.
Article
Rheumatology
Idil Esen, William F. Jiemy, Yannick van Sleen, Johan Bijzet, Daniel M. de Jong, Pieter H. Nienhuis, Riemer H. J. A. Slart, Peter Heeringa, Annemieke M. H. Boots, Elisabeth Brouwer
Summary: Circulating PKM2 levels are elevated in giant cell arteritis and correlate with other inflammatory markers. PKM2 is abundantly expressed in inflamed tissues of GCA patients and can reflect active vascular inflammation.
Review
Biochemistry & Molecular Biology
Guan-Jun Yang, Jia Wu, Chung-Hang Leung, Dik-Lung Ma, Jiong Chen
Summary: Glycolysis is a crucial step for cellular respiration, and PKM2 plays a key role in tumor cell metabolism and proliferation. Through both aerobic glycolysis and non-metabolic pathways, PKM2 contributes to leukemic proliferation, differentiation, and drug resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Oncology
Zonglei Zhao, Xixiu Wang, Yan Ding, Xuefeng Cao, Xingyuan Zhang
Summary: SMC4 is a member of the ATPase family of chromosomes and is involved in various biological functions such as compression and dissociation of sister chromatids, DNA damage repair, and transcription. It also plays a role in embryonic cell division cycle, immune response regulation, and tumor development. High expression of SMC4 is consistently associated with worse overall survival in tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiaozhen Peng, Ruochan Chen, Shenglan Cai, Shanshan Lu, Yiya Zhang
Summary: SLC1A4 expression in HCC is associated with prognosis, serving as an independent prognostic marker and being related to cell cycle, metabolism, and cancer-related pathways. Silencing SLC1A4 can inhibit proliferation, migration, cell cycle, and promote apoptosis in HCC cells, also affecting immune infiltration and chemokine expression. Additionally, potential sensitivity drugs for HCC patients with high-expressed SLC1A4 have been identified.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xujun He, Ji Xu, Nan Niu, Guoxi Xu, Honglin Zhu, Zhengchuang Liu, Yiping Mou, Zhengyuan Qian, Huiju Wang, Junfeng Hu, Tonghui Ma, Jie Ma, Houquan Tao
Summary: This study provides new insights into the mutational landscape of duodenal papillary carcinoma (DPC) and identifies PBRM1 as a key molecular driver. PBRM1 deficiency is associated with poor prognosis and may serve as a potential therapeutic target.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jae Hyeon Park, Amit Kundu, Su Hyun Lee, ChunXue Jiang, Song Hee Lee, Ye Seul Kim, So Young Kyung, So Hyun Park, Hyung Sik Kim
Summary: The study demonstrated that compound 3K had anticancer effects on PKM2-overexpressing ovarian cancer cells by regulating autophagic and apoptotic pathways, inhibiting tumor progression and reducing cell proliferation. Inhibition of PKM2 by compound 3K affected the Warburg effect and induced autophagic cell death, offering a promising therapeutic approach for treating PKM2-overexpressing ovarian cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Paula Hoffmeister-Wittmann, Andreas Mock, Federico Nichetti, Felix Korell, Christop E. Heilig, Anna-Lena Scherr, Michael Gunther, Thomas Albrecht, Eblina Kelmendi, Kaiyu Xu, Luisa Nader, Annika Kessler, Nathalie Schmitt, Sarah Fritzsche, Sofia Weiler, Benjamin Sobol, Albrecht Stenzinger, Stefan Boeck, Christoph B. Westphalen, Klaus Schulze-Osthoff, Jorg Trojan, Thomas Kindler, Wilko Weichert, Karsten Spiekermann, Michael Bitzer, Gunnar Folprecht, Anna-Lena Illert, Melanie Boerries, Frederick Klauschen, Sebastian Ochsenreiter, Jens Siveke, Sebastian Bauer, Hanno Glimm, Benedikt Brors, Jennifer Huellein, Daniel Huebschmann, Sebastian Uhrig, Peter Horak, Simon Kreutzfeld, Jesus M. Banales, Christoph Springfeld, Dirk Jaeger, Peter Schirmacher, Stephanie Roessler, Steffen Ormanns, Benjamin Goeppert, Stefan Froehling, Bruno C. Koehler
Summary: The study identified Bcl-x(L) as a key protein in cell death resistance of CCA and suggested its potential prognostic value, serving as a potential therapeutic target.
LIVER INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Thale Kristin Olsen, Cecilia Dyberg, Bethel Tesfai Embaie, Adele Alchahin, Jelena Milosevic, Jane Ding, Jorg Otte, Conny Tummler, Ida Hed Myrberg, Ellen M. Westerhout, Jan Koster, Rogier Versteeg, Han-Fei Ding, Per Kogner, John Inge Johnsen, David B. Sykes, Ninib Baryawno
Summary: By applying a multiomic system approach, researchers identified DHODH as a potential treatment target for high-risk neuroblastoma. Inhibiting DHODH could significantly reduce tumor growth and improve survival rates. Combining the DHODH inhibitor brequinar with temozolomide showed promising therapeutic potential in neuroblastoma.
Review
Biochemistry & Molecular Biology
Antonella Cormio, Francesca Sanguedolce, Vito Pesce, Clara Musicco
Summary: ClpP plays a crucial role in regulating mitochondrial function and protein homeostasis, and its overexpression in tumor cells can lead to drug resistance. Modulation of ClpP activity can impair oxidative phosphorylation in cancer cells and induce apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Wen-Zhao Luo, Xian Li, Xiu-Xia Wu, Yi-Wan Shang, Dan-Hua Meng, Yu-Long Chen, Qin-Sheng Zhang
Summary: This study investigated the expression of MAGED4B mRNA in gastric adenocarcinoma (STAD) tissues and found that high expression was associated with poor progression free survival (PFS). Furthermore, overexpression of MAGED4B enhanced the vitality, migration, and proliferation of STAD cells, while silencing of MAGED4B inhibited these cell functions. Additionally, overexpression of MAGED4B reduced cisplatin-induced apoptosis and increased cisplatin resistance, while silencing of MAGED4B promoted cisplatin-induced apoptosis and decreased cisplatin resistance. Overall, MAGED4B may serve as an important prognostic biomarker and therapeutic target for gastric adenocarcinoma.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Marina Ciscar, Eva M. Trinidad, Gema Perez-Chacon, Mansour Alsaleem, Maria Jimenez, Maria J. Jimenez-Santos, Hector Perez-Montoyo, Adrian Sanz-Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T. Soler-Monso, Victor Lopez, Jorge Gomez-Miragaya, Clara Gomez-Aleza, Lacey E. Dobrolecki, Michael T. Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela-Fandino, Fatima Al-Shahrour, Antonio Martinez-Aranda, Angels Sierra, Andrew R. Green, Emad Rakha, Eva Gonzalez-Suarez
Summary: In this study, the expression of RANK and RANKL proteins in breast cancer tumors was analyzed. It was found that RANK protein expression was associated with poor prognosis and poor response to chemotherapy in estrogen receptor-negative tumors. In breast cancer patients after menopause, RANK protein expression was associated with poor prognosis, activation of NFKB signaling, and modulation of immune and metabolic pathways. These findings suggest that RANK protein expression can serve as an independent biomarker for poor prognosis and support the use of RANK pathway inhibitors, such as denosumab, in breast cancer patients with RANK(+) estrogen receptor-negative tumors after menopause.
EMBO MOLECULAR MEDICINE
(2023)
Review
Neurosciences
Chih Hung Lo, Jialiu Zeng
Summary: Lysosomal acidification dysfunction is a key factor in the pathogenesis of neurodegenerative diseases. Genetic factors can impair lysosomal de-acidification and similar abnormalities are present in sporadic forms of neurodegeneration. Early occurrence of lysosomal acidification impairment has been observed, but there is a lack of methods and therapeutic agents for monitoring and restoring lysosomal function.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Chemistry, Medicinal
Pavels Dimitrijevs, Marina Makrecka-Kuka, Agnieszka Bogucka, Marko Hyvonen, Teodors Pantelejevs, Pavel Arsenyan
Summary: Changes in cancer metabolic pathways provide an opportunity for targeted elimination of tumor cells. The design and mechanism of action of a novel class of selective PKM2 inhibitors as anti-cancer agents are reported. Compound 5c is the most active with IC50 = 0.35 +/- 0.07 μM, downregulating PKM2 mRNA expression and inducing oxidative burst, making it cytotoxic for various cancer types. Isoselenazolium chlorides inhibit PKM2 by inducing a functionally deficient tetrameric assembly and displaying a competitive inhibitor character. The discovery of robust PKM2 inhibitors is not only valuable for anticancer therapy, but also crucial for studying the role of PKM2 in cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Rui-Lan Huang, Po-Hsuan Su, Yu-Ping Liao, Tzu-I Wu, Ya-Ting Hsu, Wei-Yu Lin, Hui-Chen Wang, Yu-Chun Weng, Yu-Che Ou, Tim Hui-Ming Huang, Hung-Cheng Lai
CLINICAL CANCER RESEARCH
(2017)
Article
Obstetrics & Gynecology
Li-Chun Liu, Hung-Cheng Lai, Yu-Ching Chou, Rui-Lan Huang, Mu-Hsien Yu, Chi-Pin Lin, Wen-Chiuan Tsai, Kai-Jo Chiang, Yu-Chi Wang, Tai-Kuang Chao
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2016)
Article
Genetics & Heredity
Vin Yee Chung, Tuan Zea Tan, Rui-Lan Huang, Hung-Cheng Lai, Ruby Yun-Ju Huang
Article
Oncology
Yaw-Wen Hsu, Rui-Lan Huang, Po-Hsuan Su, Yu-Chih Chen, Hui-Chen Wang, Chi-Chun Liao, Hung-Cheng Lai
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2017)
Article
Endocrinology & Metabolism
Chien-Wen Chen, Ya-Li Huang, Chii-Ruey Tzeng, Rui-Lan Huang, Chi-Huang Chen
Article
Oncology
Po-Hsuan Su, Yao-Wen Hsu, Rui-Lan Huang, Yu-Chun Weng, Hui-Chen Wang, Yu-Chih Chen, Yueh-Ju Tsai, Chiou-Chung Yuan, Hung-Cheng Lai
Article
Oncology
Ping-Ying Chang, Yu-Ping Liao, Hui-Chen Wang, Yu-Chih Chen, Rui-Lan Huang, Yu-Chi Wang, Chiou-Chung Yuan, Hung-Cheng Lai
Article
Oncology
Phui-Ly Liew, Rui-Lan Huang, Yu-Chun Weng, Chia-Lang Fang, Tim Hui-Ming Huang, Hung-Cheng Lai
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Oncology
Rui-Lan Huang, Hsiang-Ju Chen, Lin-Yu Chen, Tai-Kuang Chao, Wei-Yu Lin, Phui-Ly Liew, Po-Hsuan Su, Yu-Chun Weng, Yu-Chi Wang, Chi-Chun Liao, Yaw-Wen Hsu, Hui-Chen Wang, Hung-Cheng Lai
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Oncology
Hsiang-Ju Chen, Rui-Lan Huang, Phui-Ly Liew, Po-Hsuan Su, Lin-Yu Chen, Yu-Chun Weng, Cheng-Chang Chang, Yu-Chi Wang, Michael Wing-Yan Chan, Hung-Cheng Lai
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Multidisciplinary Sciences
Maggie K. S. Tang, Patrick Y. K. Yue, Philip P. Ip, Rui-Lan Huang, Hung-Cheng Lai, Annie N. Y. Cheung, Ka Yu Tse, Hextan Y. S. Ngan, Alice S. T. Wong
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Frank H. C. Cheng, Hon-Yi Lin, Tzy-Wei Hwang, Yin-Chen Chen, Rui-Lan Huang, Chia-Bin Chang, Weiqin Yang, Ru-Inn Lin, Ching-Wen Lin, Gary C. W. Chen, Shu-Yuan Mai, Jora M. J. Lin, Yu-Ming Chuang, Jian-Liang Chou, Li-Wei Kuo, Chin Li, Alfred S. L. Cheng, Hung-Cheng Lai, Shu-Fen Wu, Je-Chiang Tsai, Michael W. Y. Chan
Article
Oncology
Po-Hsuan Su, Yaw-Wen Hsu, Rui-Lan Huang, Lin-Yu Chen, Tai-Kuang Chao, Chi-Chun Liao, Chien-Wen Chen, Tzu-I. Wu, Shih-Peng Mao, Curt Balch, Hung-Cheng Lai
Article
Multidisciplinary Sciences
Po-Hsuan Su, Hung-Cheng Lai, Rui-Lan Huang, Lin-Yu Chen, Yu-Chi Wang, Tzu- Wu, Michael W. Y. Chan, Chi-Chun Liao, Chien-Wen Chen, Wei-Yu Lin, Cheng-Chang Chang
SCIENTIFIC REPORTS
(2019)