IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections

Role of Interleukin-22 in liver diseases

(2014) Chun-xiao Pan et al.   INFLAMMATION RESEARCH

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

(2013) Juanjuan Zhao et al.   HEPATOLOGY

IL-22, not simply a Th17 cytokine

(2013) Sascha Rutz et al.   IMMUNOLOGICAL REVIEWS

Therapeutic opportunities of the IL-22–IL-22R1 system

(2013) Robert Sabat et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-22 Promotes Proliferation of Liver Stem/Progenitor Cells in Mice and Patients With Chronic Hepatitis B Virus Infection

(2012) Dechun Feng et al.   GASTROENTEROLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

(2011) Ogyi Park et al.   HEPATOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3

(2010) Sung Hwan Ki et al.   HEPATOLOGY

Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections

(2010) M. S. Wilson et al.   JOURNAL OF IMMUNOLOGY

IL-22 is involved in liver regeneration after hepatectomy

(2009) Xiaodan Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice

(2009) Lies Geboes et al.   ARTHRITIS AND RHEUMATISM

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

(2009) Kristine E. Nograles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

(2009) Melba Muñoz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes

(2009) Alain Dessein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Antiapoptotic Activity of Autocrine Interleukin-22 and Therapeutic Effects of Interleukin-22-Small Interfering RNA on Human Lung Cancer Xenografts

(2008) W. Zhang et al.   CLINICAL CANCER RESEARCH

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Regulatory Role of Interleukin–10 and Interferon-γ in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected withSchistosoma japonicum

(2008) Violaine Arnaud et al.   JOURNAL OF INFECTIOUS DISEASES

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE