Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

(2016) C. Silvestre-Roig et al.   BLOOD

Matters of life and death. How neutrophils die or survive along NET release and is “NETosis” = necroptosis?

(2016) Jyaysi Desai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alterations in neonatal neutrophil function attributable to increased immature forms

(2016) Marjorie Makoni et al.   EARLY HUMAN DEVELOPMENT

Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation

(2016) Christian C. Yost et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps — the dark side of neutrophils

(2016) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Less Neutrophil Extracellular Trap Formation in Term Newborns than in Adults

(2016) Patrick Lipp et al.   Neonatology

NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways

(2016) Joshua Yuen et al.   Frontiers in Immunology

Effects of Maternal Age and Age-Specific Preterm Birth Rates on Overall Preterm Birth Rates — United States, 2007 and 2014

(2016) Cynthia Ferré et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection

(2016) Nastaran Mohammadi et al.   PLoS One

Neutrophil extracellular traps can activate alternative complement pathways

(2015) H. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Newborn infant skin: Physiology, development, and care

(2015) Marty O. Visscher et al.   CLINICS IN DERMATOLOGY

Breast milk and its impact on maturation of the neonatal immune system

(2015) Mathilde Turfkruyer et al.   CURRENT OPINION IN INFECTIOUS DISEASES

NETosis in Neonates: Evidence of a Reactive Oxygen Species–Independent Pathway in Response to Fungal Challenge

(2015) Angel S. Byrd et al.   JOURNAL OF INFECTIOUS DISEASES

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(2015) James Wynn et al.   MOLECULAR MEDICINE

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Early-Onset Neutropenia in Small-for-Gestational-Age Infants

(2015) R. D. Christensen et al.   PEDIATRICS

A Randomized Case-Controlled Study of Recombinant Human Granulocyte Colony Stimulating Factor for the Treatment of Sepsis in Preterm Neutropenic Infants

(2015) Doğukan Aktaş et al.   Pediatrics and Neonatology

Neutrophil Leukocyte: Combustive Microbicidal Action and Chemiluminescence

(2015) Robert C. Allen   Journal of Immunology Research

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Central Role of Conventional Dendritic Cells in Regulation of Bone Marrow Release and Survival of Neutrophils

(2014) J. Jiao et al.   JOURNAL OF IMMUNOLOGY

Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter

(2014) Corryn Greenwood et al.   JOURNAL OF PEDIATRICS

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

A Prime Time for Trained Immunity: Innate Immune Memory in Newborns and Infants

(2014) Ofer Levy et al.   Neonatology

Role of Guidelines on Length of Therapy in Chorioamnionitis and Neonatal Sepsis

(2014) C. Kiser et al.   PEDIATRICS

Granule Protein Processing and Regulated Secretion in Neutrophils

(2014) Avinash Sheshachalam et al.   Frontiers in Immunology

Hypoxia and HIFs in regulating the development of the hematopoietic system

(2013) Parisa Imanirad et al.   BLOOD CELLS MOLECULES AND DISEASES

Cord blood neutrophils display a galectin-3 responsive phenotype accentuated by vaginal delivery

(2013) Martina Sundqvist et al.   BMC Pediatrics

Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease

(2013) Wenli Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR2-Induced IL-10 Production Impairs Neutrophil Recruitment to Infected Tissues during Neonatal Bacterial Sepsis

(2013) E. B. Andrade et al.   JOURNAL OF IMMUNOLOGY

Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease

(2013) Natasha Strydom et al.   Journal of Innate Immunity

Expression profile of cord blood neutrophils and dysregulation of HSPA1A and OLR1 upon challenge by bacterial peptidoglycan

(2013) O. N. Fong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Galectin-3 plays an important role in protection against disseminated candidiasis

(2013) Jennifer R. Linden et al.   MEDICAL MYCOLOGY

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

(2013) Amanda Welin et al.   PLoS One

The embryonic origins of erythropoiesis in mammals

(2012) M. H. Baron et al.   BLOOD

The role of galectin-3 in phagocytosis ofCandida albicansandCandida parapsilosisby human neutrophils

(2012) Jennifer R. Linden et al.   CELLULAR MICROBIOLOGY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Neutrophil and endothelial adhesive function during human fetal ontogeny

(2012) C. Nussbaum et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Signal transduction pathways regulating hematopoietic stem cell biology: Introduction to a series of Spotlight Reviews

(2012) T C Luis et al.   LEUKEMIA

The Impact of Various Reactive Oxygen Species on the Formation of Neutrophil Extracellular Traps

(2012) Tina Kirchner et al.   MEDIATORS OF INFLAMMATION

New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors

(2012) Ross Corriden et al.   Purinergic Signalling

Risk Assessment in Neonatal Early Onset Sepsis

(2012) Sagori Mukhopadhyay et al.   SEMINARS IN PERINATOLOGY

Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes

(2012) Pei-Chen Hou et al.   TheScientificWorldJOURNAL

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Serglycin participates in retention of  -defensin in granules during myelopoiesis

(2011) A. Glenthoj et al.   BLOOD

Phagocytic ability of neutrophils and monocytes in neonates

(2011) Athanasios Filias et al.   BMC Pediatrics

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes

(2011) Nicholas T. Funderburg et al.   IMMUNOLOGY

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate immune cell recruitment in the fetus and neonate

(2011) Claudia Nussbaum et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Toll-Like Receptor 1/2 Stimulation Induces Elevated Interleukin-8 Secretion in Polymorphonuclear Leukocytes Isolated from Preterm and Term Newborn Infants

(2011) Nathan L. Thornton et al.   Neonatology

Treatment of Neonatal Sepsis with Intravenous Immune Globulin

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

LPS-Induced Galectin-3 Oligomerization Results in Enhancement of Neutrophil Activation

(2011) Marise Lopes Fermino et al.   PLoS One

Intrauterine Growth Retardation in Preterm Infants ≤32 Weeks of Gestation is Associated with Low White Blood Cell Counts

(2010) Johannes Wirbelauer et al.   AMERICAN JOURNAL OF PERINATOLOGY

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Neutrophil adhesion molecules in term and premature infants: normal or enhanced leucocyte integrins but defective L-selectin expression and shedding

(2010) N. REBUCK et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of Innate Host Defenses in Susceptibility to Early-Onset Neonatal Sepsis

(2010) James L. Wynn et al.   CLINICS IN PERINATOLOGY

Biosynthesis, processing and sorting of neutrophil proteins: insight into neutrophil granule development

(2010) Urban Gullberg et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

(2009) C. C. Yost et al.   BLOOD

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Oxidative burst and phagocytosis of neonatal neutrophils confronting Candida albicans and Candida parapsilosis

(2009) Kisha G. Destin et al.   EARLY HUMAN DEVELOPMENT

HIF-1 in the inflammatory microenvironment

(2009) Nathalie Dehne et al.   EXPERIMENTAL CELL RESEARCH

Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial

(2009) Robert Carr et al.   LANCET

Siglec-9 and SHP-1 Are Differentially Expressed in Neonatal and Adult Neutrophils

(2009) Ramachandran Rashmi et al.   PEDIATRIC RESEARCH

Developmental Biology of the Innate Immune Response: Implications for Neonatal and Infant Vaccine Development

(2009) Victoria Jane Philbin et al.   PEDIATRIC RESEARCH

Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines

(2008) Peter C. E. Burdon et al.   BRITISH JOURNAL OF HAEMATOLOGY

The  -galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist

(2008) H. Forsman et al.   GLYCOBIOLOGY

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine

(2008) Ross Corriden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early neutropenia is not associated with an increased rate of nosocomial infection in very low-birth-weight infants

(2008) R-J Teng et al.   Journal of Perinatology

Expected ranges for blood neutrophil concentrations of neonates: the Manroe and Mouzinho charts revisited

(2008) N Schmutz et al.   Journal of Perinatology

Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis

(2008) M. J. Bizzarro et al.   PEDIATRICS

Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants

(2008) C. M. Cotten et al.   PEDIATRICS