Molecular Targets of Active Anticancer Compounds Derived from Marine Sources

Protein kinase C activator bryostatin-1 modulates proteasome function

(2018) Tapan K. Khan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sulawesins A–C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a Psammocinia sp. Marine Sponge

(2017) Ahmed H. Afifi et al.   JOURNAL OF NATURAL PRODUCTS

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

(2017) Alejandro Mayer et al.   Marine Drugs

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents

(2017) Laura Llorach-Pares et al.   Marine Drugs

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

(2017) Verónica Ruiz-Torres et al.   MOLECULES

Cytotoxic effects of the anthraquinone derivatives 1′-deoxyrhodoptilometrin and (S)-(−)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.

(2016) Wim Wätjen et al.   ARCHIVES OF TOXICOLOGY

Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure–activity study on simplified analogs of the receptor-recognition domain

(2016) Yoshiki Ashida et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy

(2016) Takahiro Domoto et al.   CANCER SCIENCE

Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction

(2016) Andrew K. L. Goey et al.   JOURNAL OF NATURAL PRODUCTS

Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β

(2016) Jutta Wiese et al.   Marine Drugs

Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells

(2016) Ana Zovko et al.   Oncotarget

Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1

(2016) Yong-Joon Choi et al.   Oncotarget

Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

(2016) Kuei-Hung Lai et al.   Scientific Reports

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+pumps with a unique mode of binding

(2015) Maho Morita et al.   FEBS LETTERS

Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects

(2015) Shuaiyu Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anticancer agent-based marine natural products and related compounds

(2015) Jian-Wei Chen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

(2015) Shou-Ping Shih et al.   Marine Drugs

Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating β1-Integrin/FAK Signaling

(2015) Ning Wu et al.   Marine Drugs

Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?

(2015) Nelson Gomes et al.   Marine Drugs

Marine Natural Products as Breast Cancer Resistance Protein Inhibitors

(2015) Lilia Cherigo et al.   Marine Drugs

Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of patched and increase chemotherapy efficiency on melanoma cells

(2015) Laura Fiorini et al.   Oncotarget

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

(2015) Xiaoping Song et al.   Oncotarget

Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin

(2014) Kazuhiro Irie et al.   CHEMICAL RECORD

Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses

(2014) K. Coughlin et al.   CLINICAL CANCER RESEARCH

Metal-based 2,3-indolinedione derivatives as proteasome inhibitors and inducers of apoptosis in human cancer cells

(2014) PENGFEI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Bazedoxifene-Scaffold-Based Mimetics of Solomonsterols A and B as Novel Pregnane X Receptor Antagonists

(2014) Žiga Hodnik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Marine Sponge Cribrochalina vasculum Compounds Activate Intrinsic Apoptotic Signaling and Inhibit Growth Factor Signaling Cascades in Non-Small Cell Lung Carcinoma

(2014) A. Zovko et al.   MOLECULAR CANCER THERAPEUTICS

Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling

(2014) Asmaa A. Sallam et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs

(2014) Paul A. Wender et al.   ORGANIC LETTERS

Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor

(2013) Michitaka Yamaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Successful importation of cytarabine into the United States during a critical national drug shortage

(2012) D. Hunnisett-Dritz   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium

(2012) Alban R. Pereira et al.   CHEMBIOCHEM

Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin

(2012) Axel Bidon-Chanal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets

(2012) Matthias G. J. Baud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities

(2012) Raquel Pereira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance

(2012) Ioana Abraham et al.   Marine Drugs

Mycalamide A Shows Cytotoxic Properties and Prevents EGF-Induced Neoplastic Transformation through Inhibition of Nuclear Factors

(2012) Sergey A. Dyshlovoy et al.   Marine Drugs

Meridianins: Marine-Derived Potent Kinase Inhibitors

(2012) S. B. Bharate et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

(2012) Simona De Marino et al.   STEROIDS

Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction

(2011) Karla L. Malloy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors

(2011) Giorgio V. Scagliotti et al.   CANCER TREATMENT REVIEWS

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Brentuximab Vedotin (SGN-35)

(2011) J. Katz et al.   CLINICAL CANCER RESEARCH

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

(2011) Susanna Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the hedgehog signaling pathway with interacting peptides to Patched-1

(2011) Masafumi Nakamura et al.   JOURNAL OF GASTROENTEROLOGY

Kinase Inhibitors from Marine Sponges

(2011) Danielle Skropeta et al.   Marine Drugs

Dihydrohymenialdisines, new pyrrole-2-aminoimidazole alkaloids from the marine sponge Cymbastela cantharella

(2011) Pierre Sauleau et al.   TETRAHEDRON LETTERS

Targeting the insulin-like growth factor receptor pathway in lung cancer: problems and pitfalls

(2011) Mary Jo Fidler et al.   Therapeutic Advances in Medical Oncology

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells

(2010) Ioana Abraham et al.   BIOCHEMICAL PHARMACOLOGY

A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

(2010) Esther A. Guzmán et al.   INVESTIGATIONAL NEW DRUGS

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

(2010) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

(2010) Barbara C. Potts et al.   Marine Drugs

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui

(2009) G. Gurel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The inhibition of TNF-α-induced NF-κB activation by marine natural products

(2009) Florence Folmer et al.   BIOCHEMICAL PHARMACOLOGY

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

(2009) Shensi Shen et al.   JOURNAL OF CELL BIOLOGY

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Antitumour polyether macrolides: Four new halichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp.

(2008) Sarah J.H. Hickford et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

(2008) C. M. Sloss et al.   CLINICAL CANCER RESEARCH

Advances in and applications of proteasome inhibitors

(2008) Bradley S Moore et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Product-likeness Score and Its Application for Prioritization of Compound Libraries

(2007) Peter Ertl et al.   Journal of Chemical Information and Modeling