Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy

Targeting Cancer Stem Cells: Promises and Challenges

(2015) Jan Dominik Kuhlmann et al.   Anti-Cancer Agents in Medicinal Chemistry

Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

(2015) Yuki Yoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combining targeted therapeutics in the era of precision medicine

(2015) D Papadatos-Pastos et al.   BRITISH JOURNAL OF CANCER

GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway

(2015) Xu Ying et al.   Cancer Cell International

Prodding the Beast: Assessing the Impact of Treatment-Induced Metastasis

(2015) J. M. L. Ebos   CANCER RESEARCH

Intratumoral Heterogeneity: From Diversity Comes Resistance

(2015) A. Pribluda et al.   CLINICAL CANCER RESEARCH

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy

(2015) A Borah et al.   Oncogenesis

Glycogen synthase kinase-3β inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth

(2015) Jan Kroon et al.   Oncotarget

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells

(2015) Yuki Yoshino et al.   Scientific Reports

Glycogen Synthase Kinase 3  Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway

(2014) Y. Chikano et al.   MOLECULAR CANCER THERAPEUTICS

Mechanism-based cancer therapy: resistance to therapy, therapy for resistance

(2014) P Ramos et al.   ONCOGENE

GSK3β Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells

(2014) Jing Zeng et al.   PLoS One

Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation

(2014) Emma E. Vincent et al.   PLoS One

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/ -catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma

(2014) E. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activator or inhibitor? GSK-3 as a new drug target

(2013) Fumi Takahashi-Yanaga   BIOCHEMICAL PHARMACOLOGY

Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O 6 -methylguanine DNA methyltransferase promoter methylation via c-Myc signaling

(2013) Ilya V. Pyko et al.   CARCINOGENESIS

Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy

(2013) E. Grassilli et al.   CLINICAL CANCER RESEARCH

Glycogen Synthase Kinase 3β Inhibition as a Therapeutic Approach in the Treatment of Endometrial Cancer

(2013) Yan Yin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of GSK-3 Induces Differentiation and Impaired Glucose Metabolism in Renal Cancer

(2013) K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

Invading one step at a time: the role of invadopodia in tumor metastasis

(2013) H Paz et al.   ONCOGENE

Aberrant Glycogen Synthase Kinase 3β Is Involved in Pancreatic Cancer Cell Invasion and Resistance to Therapy

(2013) Ayako Kitano et al.   PLoS One

An Emerging Strategy for Cancer Treatment Targeting Aberrant Glycogen Synthase Kinase 3β

(2012) Katsuyoshi Miyashita et al.   Anti-Cancer Agents in Medicinal Chemistry

GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC)

(2012) Hisashi Kawazoe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Dark Side of E2F1: In Transit beyond Apoptosis

(2012) D. Engelmann et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer

(2012) R. Siobhan Darrington et al.   INTERNATIONAL JOURNAL OF CANCER

Glycogen Synthase Kinase-3β, NF-κB Signaling, and Tumorigenesis of Human Osteosarcoma

(2012) Qing-Lian Tang et al.   JNCI-Journal of the National Cancer Institute

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments

(2011) S. P. Williams et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cancer Stem Cells and Chemosensitivity

(2011) M. Maugeri-Sacca et al.   CLINICAL CANCER RESEARCH

Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine

(2011) Takeo Shimasaki et al.   JOURNAL OF GASTROENTEROLOGY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway

(2011) Mohammad Reza Mirlashari et al.   LEUKEMIA RESEARCH

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure

(2011) Stephanie Alexander et al.   TRENDS IN MOLECULAR MEDICINE

Glycogen Synthase Kinase-3 : A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer

(2010) S. Naito et al.   CLINICAL CANCER RESEARCH

Targeting the RB-pathway in Cancer Therapy

(2010) E. S. Knudsen et al.   CLINICAL CANCER RESEARCH

Glycogen synthase kinase 3 in the world of cell migration

(2010) Tong Sun et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo

(2010) Qing Zhu et al.   PROSTATE

Glycogen synthase kinase 3 regulates PAX3–FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells

(2009) Fu-Yue Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma

(2009) V Bilim et al.   BRITISH JOURNAL OF CANCER

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Potential Therapeutic Effect of Glycogen Synthase Kinase 3  Inhibition against Human Glioblastoma

(2009) K. Miyashita et al.   CLINICAL CANCER RESEARCH

Deregulated GSK3  Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase

(2009) W. Mai et al.   CLINICAL CANCER RESEARCH

Glycogen synthase kinases-3β controls differentiation of malignant glioma cells

(2009) Yan Li et al.   INTERNATIONAL JOURNAL OF CANCER

GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma

(2009) Serdar Korur et al.   PLoS One

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

(2009) Eléonore Beurel et al.   TRENDS IN IMMUNOLOGY

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

Maintenance of Constitutive I B Kinase Activity by Glycogen Synthase Kinase-3 /  in Pancreatic Cancer

(2008) W. Wilson et al.   CANCER RESEARCH

Glycogen Synthase Kinase-3 Inhibition Induces Glioma Cell Death through c-MYC, Nuclear Factor- B, and Glucose Regulation

(2008) S. Kotliarova et al.   CANCER RESEARCH

Lamellipodia and filopodia in metastasis and invasion

(2008) Laura M. Machesky   FEBS LETTERS

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE

Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3

(2008) Michal O. Nowicki et al.   NEURO-ONCOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE