Recent advances in microfluidic technologies for cell-to-cell interaction studies

Bridging the gap: microfluidic devices for short and long distance cell–cell communication

(2017) Timothy Quang Vu et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity

(2017) Shih-Yu Chang et al.   TOXICOLOGY IN VITRO

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells

(2017) Stefania Parlato et al.   Scientific Reports

Microfluidic models for adoptive cell-mediated cancer immunotherapies

(2016) Giulia Adriani et al.   DRUG DISCOVERY TODAY

Development of a microphysiological model of human kidney proximal tubule function

(2016) Elijah J. Weber et al.   KIDNEY INTERNATIONAL

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

A microphysiological model of the human placental barrier

(2016) Cassidy Blundell et al.   LAB ON A CHIP

Three-dimensional manipulation of single cells using surface acoustic waves

(2016) Feng Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Impedance Spectroscopy for Microtissue Spheroid Analysis in Hanging-Drop Networks

(2016) Yannick R. F. Schmid et al.   ACS Sensors

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Recent advances and future applications of microfluidic live-cell microarrays

(2015) Mario Rothbauer et al.   BIOTECHNOLOGY ADVANCES

Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

(2015) Young Bok Abraham Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions

(2015) E. E. Zahavi et al.   JOURNAL OF CELL SCIENCE

Placenta-on-a-chip: a novel platform to study the biology of the human placenta

(2015) Ji Soo Lee et al.   Journal of Maternal-Fetal & Neonatal Medicine

In vitro micro-physiological models for translational immunology

(2015) Qasem Ramadan et al.   LAB ON A CHIP

Adding the ‘heart’ to hanging drop networks for microphysiological multi-tissue experiments

(2015) Saeed Rismani Yazdi et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications

(2015) Drago Sticker et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering opportunities in cancer immunotherapy

(2015) Laura Jeanbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Microfluidics for cell-cell interactions: A review

(2015) Rui Li et al.   Frontiers of Chemical Science and Engineering

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

(2015) David Wartmann et al.   Frontiers in Materials

Electrolytic valving isolation of cell co-culture microenvironment with controlled cell pairing ratios

(2014) Yu-Chih Chen et al.   ANALYST

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

A microfluidic co-culture system to monitor tumor-stromal interactions on a chip

(2014) Nishanth V. Menon et al.   Biomicrofluidics

Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform

(2014) Andrew D. Wong et al.   CANCER RESEARCH

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

A multidisciplinary study usingin vivotumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells

(2014) Fabrizio Mattei et al.   Journal of Immunotoxicology

A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening

(2014) K. Kwapiszewska et al.   LAB ON A CHIP

Block-Cell-Printing for live single-cell printing

(2014) K. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic chip with a U-shaped microstructure array for multicellular spheroid formation, culturing and analysis

(2014) Chien-Yu Fu et al.   Biofabrication

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Brain microvascular endothelial cells resist elongation due to curvature and shear stress

(2014) Mao Ye et al.   Scientific Reports

Cancer-driven dynamics of immune cells in a microfluidic environment

(2014) Elena Agliari et al.   Scientific Reports

Anisotropic Crystalline Protein Nanolayers as Multi-Functional Biointerface for Patterned Co-Cultures of Adherent and Non-Adherent Cells in Microfluidic Devices

(2014) Mario Rothbauer et al.   Advanced Materials Interfaces

Microfluidics co-culture systems for studying tooth innervation

(2014) Pierfrancesco Pagella et al.   Frontiers in Physiology

Exploitation of S-Layer Anisotropy: pH-Dependent Nanolayer Orientation for Cellular Micropatterning

(2013) Mario Rothbauer et al.   ACS Nano

Monitoring Dynamic Interactions of Tumor Cells with Tissue and Immune Cells in a Lab-on-a-Chip

(2013) Verena Charwat et al.   ANALYTICAL CHEMISTRY

3D-printed devices for continuous-flow organic chemistry

(2013) Vincenza Dragone et al.   Beilstein Journal of Organic Chemistry

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Organs-on-a-chip for drug discovery

(2013) Šeila Selimović et al.   CURRENT OPINION IN PHARMACOLOGY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Effects of Mechanical and Chemical Stimuli on Differentiation of Human Adipose-Derived Stem Cells into Endothelial Cells

(2013) Shahrokh Shojaei et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model

(2013) Scott S. Verbridge et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Nano-volume drop patterning for rapid on-chip neuronal connect-ability assays

(2013) Alessia Petrelli et al.   LAB ON A CHIP

Microfluidic oxygen imaging using integrated optical sensor layers and a color camera

(2013) Birgit Ungerböck et al.   LAB ON A CHIP

Rapid fabrication of nickel molds for prototyping embossed plastic microfluidic devices

(2013) Richard Novak et al.   LAB ON A CHIP

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

(2013) Mingjian Shi et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capillary-valve-based platform towards cell-on-chip mechanotransduction assays

(2013) Tanja C. Hausherr et al.   SENSORS AND ACTUATORS B-CHEMICAL

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System

(2013) Jordan A. Whisler et al.   TISSUE ENGINEERING PART C-METHODS

Three-Dimensional Microfluidic Collagen Hydrogels for Investigating Flow-Mediated Tumor-Endothelial Signaling and Vascular Organization

(2013) Cara F. Buchanan et al.   TISSUE ENGINEERING PART C-METHODS

High-throughput co-encapsulation of self-ordered cell trains: cell pair interactions in microdroplets

(2013) Todd P. Lagus et al.   RSC Advances

An integrated in vitro model of perfused tumor and cardiac tissue

(2013) Monica Moya et al.   Stem Cell Research & Therapy

Quantitative Study of the Dynamic Tumor–Endothelial Cell Interactions through an Integrated Microfluidic Coculture System

(2012) Chunhong Zheng et al.   ANALYTICAL CHEMISTRY

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Integrated Microfluidics Platforms for Investigating Injury and Regeneration of CNS Axons

(2012) Hyung Joon Kim et al.   ANNALS OF BIOMEDICAL ENGINEERING

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Neuroscience goes on a chip

(2012) Aung K. Soe et al.   BIOSENSORS & BIOELECTRONICS

Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer

(2012) Jin Zheng et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Single-cell level co-culture platform for intercellular communication

(2012) Soongweon Hong et al.   Integrative Biology

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

(2012) Ju Hun Yeon et al.   LAB ON A CHIP

Multi-compartment neuron–glia co-culture platform for localized CNS axon–glia interaction study

(2012) Jaewon Park et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Brain slice on a chip: opportunities and challenges of applying microfluidic technology to intact tissues

(2012) Yu Huang et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

(2012) Luca Businaro et al.   LAB ON A CHIP

Standardization of microfluidic cell cultures using integrated organic photodiodes and electrode arrays

(2012) Verena Charwat et al.   LAB ON A CHIP

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

Emergent Functional Properties of Neuronal Networks with Controlled Topology

(2012) Emanuele Marconi et al.   PLoS One

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Development of a three-dimensional microfluidic system for long-term tumor spheroid culture

(2012) Karina Ziółkowska et al.   SENSORS AND ACTUATORS B-CHEMICAL

Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform (MCP)-based Neuronal Axon and Glia Co-culture System

(2012) Haruki Higashimori et al.   Jove-Journal of Visualized Experiments

Mechanical stimulation of bovine embryos in a microfluidic culture platform

(2011) Chae Yun Bae et al.   BioChip Journal

A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology

(2011) Yandong Gao et al.   BIOMEDICAL MICRODEVICES

A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells

(2011) Thurston Herricks et al.   LAB ON A CHIP

Mechanical stimulation of epithelial cells using polypyrrole microactuators

(2011) Karl Svennersten et al.   LAB ON A CHIP

A living system on a chip

(2011) Monya Baker   NATURE

Endothelial Cells in Co-culture Enhance Embryonic Stem Cell Differentiation to Pancreatic Progenitors and Insulin-Producing Cells through BMP Signaling

(2011) Dodanim Talavera-Adame et al.   Stem Cell Reviews and Reports

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

(2011) Yu Huang et al.   Jove-Journal of Visualized Experiments

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Compartmental culture of embryonic stem cell-derived neurons in microfluidic devices for use in axonal biology

(2010) Hwa Sung Shin et al.   BIOTECHNOLOGY LETTERS

Micro-scale and microfluidic devices for neurobiology

(2010) Anne M Taylor et al.   CURRENT OPINION IN NEUROBIOLOGY

Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device

(2010) Huipeng Ma et al.   ELECTROPHORESIS

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

3D microchannel co-culture: method and biological validation

(2010) Maret Bauer et al.   Integrative Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Co-culture of neurons and glia in a novel microfluidic platform

(2010) Devi Majumdar et al.   JOURNAL OF NEUROSCIENCE METHODS

Directing the flow of medium in controlled cocultures of HeLa cells and human umbilical vein endothelial cells with a microfluidic device

(2010) Hirokazu Kaji et al.   LAB ON A CHIP

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

A multicellular spheroid formation and extraction chip using removable cell trapping barriers

(2010) Hye-Jin Jin et al.   LAB ON A CHIP

Microfluidic Local Perfusion Chambers for the Visualization and Manipulation of Synapses

(2010) Anne M. Taylor et al.   NEURON

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Simultaneous generation of chemical concentration and mechanical shear stress gradients using microfluidic osmotic flow comparable to interstitial flow

(2009) Joong Yull Park et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Patterning bio-molecules for cell attachment at single cell levels in PDMS microfluidic chips

(2009) L. Wang et al.   MICROELECTRONIC ENGINEERING

Microfluidic control of cell pairing and fusion

(2009) Alison M Skelley et al.   NATURE METHODS

Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system

(2008) Zhizhong Yin et al.   Molecular Systems Biology

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS