Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-β Protein Precursor and Amyloid-β

(2017) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species

(2014) Steven L. Wagner et al.   BIOCHEMISTRY

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

An Antidepressant Decreases CSF A  Production in Healthy Individuals and in Transgenic AD Mice

(2014) Y. I. Sheline et al.   Science Translational Medicine

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Longitudinal Amyloid Imaging in Mouse Brain with 11C-PIB: Comparison of APP23, Tg2576, and APPswe-PS1dE9 Mouse Models of Alzheimer Disease

(2013) A. Snellman et al.   JOURNAL OF NUCLEAR MEDICINE

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reply: Beyond the limits of detection: Failure of PiB imaging to capture true Aβ burden

(2013) Stephen N. Gomperts et al.   MOVEMENT DISORDERS

Beyond the limits of detection: Failure of PiB imaging to capture true Aβ burden

(2013) Michail E. Kalaitzakis et al.   MOVEMENT DISORDERS

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Pollination Decline in Context--Response

(2013) J. M. Tylianakis   SCIENCE

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

(2012) Masahiro Ono et al.   ACS Chemical Neuroscience

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Molecular imaging of dementia

(2012) Takaaki MORI et al.   Psychogeriatrics

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents

(2012) Chester A. Mathis et al.   SEMINARS IN NUCLEAR MEDICINE

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

(2011) Willy M. Chang et al.   ACS Chemical Neuroscience

Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes

(2011) Julie Lee et al.   BIOCHEMISTRY

Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors

(2011) Christopher J. Monceaux et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Structure−Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques

(2011) Mengchao Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

NIA Commentary: Translational Issues in Alzheimer’s Disease Drug Development

(2011) Neil S Buckholtz et al.   NEUROPSYCHOPHARMACOLOGY

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species

(2011) Chongzhao Ran et al.   PLoS One

Molecular imaging in Alzheimer's disease: new perspectives on biomarkers for early diagnosis and drug development

(2011) Agneta Nordberg   Alzheimers Research & Therapy

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of PET in Alzheimer disease

(2010) Agneta Nordberg et al.   Nature Reviews Neurology

Ante mortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies

(2010) Kejal Kantarci et al.   NEUROBIOLOGY OF AGING

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural integrity of β-sheet assembly

(2009) Karen E. Marshall et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation

(2009) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preclinical Properties of 18F-AV-45: A PET Agent for A  Plaques in the Brain

(2009) S. R. Choi et al.   JOURNAL OF NUCLEAR MEDICINE

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease

(2009) Claudia Kuntner et al.   MOLECULAR IMAGING AND BIOLOGY

β-Amyloid, Blood Vessels, and Brain Function

(2009) Eric E. Smith et al.   STROKE

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase‡

(2008) James C. Barrow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroscience: The plaque plan

(2008) Alison Abbott   NATURE

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

A Craniotomy Surgery Procedure for Chronic Brain Imaging

(2008) Ricardo Mostany et al.   Jove-Journal of Visualized Experiments