Structure-based drug design identifies polythiophenes as antiprion compounds

Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts

(2014) Rozalyn A. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids

(2014) Bradley R. Groveman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial

(2014) Stéphane Haïk et al.   LANCET NEUROLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

(2014) J. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates

(2013) Therése Klingstedt et al.   CHEMISTRY-A EUROPEAN JOURNAL

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

(2013) Tiziana Sonati et al.   NATURE

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases

(2013) Mathéa Pietri et al.   NATURE MEDICINE

Drug resistance confounding prion therapeutics

(2013) D. B. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics

(2013) Florent Laferrière et al.   PLoS Pathogens

Effect of Immunotherapy With Bapineuzumab on Cerebrospinal Fluid Biomarker Levels in Patients With Mild to Moderate Alzheimer Disease

(2012) Henrik Zetterberg   ARCHIVES OF NEUROLOGY

Multiple Substitutions of Methionine 129 in Human Prion Protein Reveal Its Importance in the Amyloid Fibrillation Pathway

(2012) Sofie Nyström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

(2012) Ilan Margalith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

High-resolution structure of infectious prion protein: the final frontier

(2012) Rodrigo Diaz-Espinoza et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

(2012) Jeppe Falsig et al.   PLoS Pathogens

The Amyloid-Congo Red Interface at Atomic Resolution

(2011) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interactions between a luminescent conjugated polyelectrolyte and amyloid fibrils investigated with flow linear dichroism spectroscopy

(2011) Jens Wigenius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Universal Method for Detection of Amyloidogenic Misfolded Proteins

(2011) Alice Y. Yam et al.   BIOCHEMISTRY

Oligomeric-Induced Activity by Thienyl Pyrimidine Compounds Traps Prion Infectivity

(2011) A. Ayrolles-Torro et al.   JOURNAL OF NEUROSCIENCE

Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion

(2011) Hiroyuki Honda et al.   NEUROPATHOLOGY

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ruthenium-Catalyzed Oxidative Vinylation of Heteroarene Carboxylic Acids with Alkenes via Regioselective C−H Bond Cleavage

(2011) Takumi Ueyama et al.   ORGANIC LETTERS

The α-Helical C-Terminal Domain of Full-Length Recombinant PrP Converts to an In-Register Parallel β-Sheet Structure in PrP Fibrils: Evidence from Solid State Nuclear Magnetic Resonance

(2010) Robert Tycko et al.   BIOCHEMISTRY

Atypical Prion Protein Conformation in Familial Prion Disease with PRNP P105T Mutation

(2010) Magdalini Polymenidou et al.   BRAIN PATHOLOGY

Rapidly progressive dementias and the treatment of human prion diseases

(2010) Brian S Appleby et al.   EXPERT OPINION ON PHARMACOTHERAPY

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

The HADDOCK web server for data-driven biomolecular docking

(2010) Sjoerd J de Vries et al.   Nature Protocols

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Amyloid fibrils of human prion protein are spun and woven from morphologically disordered aggregates

(2010) Karin Almstedt et al.   Prion

The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent

(2010) Philippe Tixador et al.   PLoS Pathogens

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

Structural Typing of Systemic Amyloidoses by Luminescent-Conjugated Polymer Spectroscopy

(2009) K. Peter R. Nilsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Controlling Rigidity and Planarity in Conjugated Polymers: Poly(3,4-ethylenedithioselenophene)

(2009) Yair H. Wijsboom et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Complex Polyamines: Unique Prion Disaggregating Compounds

(2009) Surachai Supattapone et al.   CNS & Neurological Disorders-Drug Targets

Prion protein library of recombinant constructs for structural biology

(2009) Simone Hornemann et al.   FEBS Journal

Polyselenophenes

(2009) Asit Patra et al.   JOURNAL OF MATERIALS CHEMISTRY

Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial

(2009) John Collinge et al.   LANCET NEUROLOGY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions

(2009) Sina Ghaemmaghami et al.   PLoS Pathogens

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE