Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications

Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis

(2018) Ilanit Boyango et al.   MATRIX BIOLOGY

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression

(2017) Preeti Singh et al.   NEOPLASIA

Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation: Risk Factors and Stratification, Prophylaxis, and Treatment

(2016) Jean-Hugues Dalle et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The IASLC Mesothelioma Staging Project: Proposals for the M Descriptors and for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Mesothelioma

(2016) Valerie W. Rusch et al.   Journal of Thoracic Oncology

Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial

(2016) Gérard Zalcman et al.   LANCET

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype

(2016) Vishnu C. Ramani et al.   MATRIX BIOLOGY

Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis

(2016) Marina Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparanase is required for activation and function of macrophages

(2016) Lilach Gutter-Kapon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy

(2015) Anna Shteingauz et al.   CANCER RESEARCH

PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples

(2015) Boris Winterhoff et al.   EUROPEAN JOURNAL OF CANCER

Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma

(2015) Vishnu C. Ramani et al.   Oncotarget

Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies

(2015) Angela Bononi et al.   Expert Review of Respiratory Medicine

The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers

(2015) Hideki Ujiie et al.   OncoImmunology

Heparanase Cooperates with Ras to Drive Breast and Skin Tumorigenesis

(2014) I. Boyango et al.   CANCER RESEARCH

Heparanase enhances myeloma progression via CXCL10 downregulation

(2014) U Barash et al.   LEUKEMIA

Molecular pathogenesis of malignant mesothelioma

(2013) Y. Sekido   CARCINOGENESIS

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

The heparanase system and tumor metastasis: is heparanase the seed and soil?

(2011) Gil Arvatz et al.   CANCER AND METASTASIS REVIEWS

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Malignant mesothelioma: Facts, Myths, and Hypotheses

(2011) Michele Carbone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Asbestos, Lung Cancers, and Mesotheliomas

(2010) Nicholas H. Heintz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Post-transcriptional regulation of heparanase gene expression by a 3′ AU-rich element

(2010) Gil Arvatz et al.   FASEB JOURNAL

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

(2009) Eyal Zcharia et al.   PLoS One

Use of defibrotide in the treatment and prevention of veno-occlusive disease

(2009) Paul Richardson et al.   Expert Review of Hematology

p21 and p27: roles in carcinogenesis and drug resistance

(2008) Abde M. Abukhdeir et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE