Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?

Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

(2013) Marcus A Lawson et al.   Journal of Neuroinflammation

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

p38 MAP kinase activation does not stimulate serotonin transport in rat brain: Implications for sickness behaviour mechanisms

(2013) Filippo Andreetta et al.   LIFE SCIENCES

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: An intracranial self-stimulation study

(2012) Floor van Heesch et al.   BRAIN BEHAVIOR AND IMMUNITY

In vitro evidence for the brain glutamate efflux hypothesis: Brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

(2012) Hans Christian Helms et al.   GLIA

Blood Glutamate Scavenging: Insight into Neuroprotection

(2012) Akiva Leibowitz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

(2012) Junpei Takaki et al.   Journal of Neuroinflammation

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Neuroinflammation and Depression

(2012) M. Elizabeth Sublette et al.   PSYCHOSOMATIC MEDICINE

EAAT expression by macrophages and microglia: still more questions than answers

(2011) Gabriel Gras et al.   AMINO ACIDS

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo

(2011) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department

(2011) Gregory Luke Larkin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: Evidence from the Young Finns study

(2011) Marko Elovainio et al.   JOURNAL OF AFFECTIVE DISORDERS

Mechanisms of Glutamate Efflux at the Blood—Brain Barrier: Involvement of Glial Cells

(2011) Katayun Cohen-Kashi-Malina et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: An experimental study

(2011) Francisco Campos et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The possible role of the kynurenine pathway in anhedonia in adolescents

(2011) Vilma Gabbay et al.   JOURNAL OF NEURAL TRANSMISSION

The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment

(2011) Allison B Gold et al.   Journal of Neuroinflammation

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Effects of Blood Glutamate Scavenging on Cortical Evoked Potentials

(2010) Dávid Nagy et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Association between increased tryptophan degradation and depression in cancer patients

(2010) Katharina Kurz et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

(2010) Xin Fu et al.   Journal of Neuroinflammation

Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters

(2010) Chong-Bin Zhu et al.   NEUROPSYCHOPHARMACOLOGY

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

5-Hydroxyanthranilic Acid, a Tryptophan Metabolite, Generates Oxidative Stress and Neuronal Death via p38 Activation in Cultured Cerebellar Granule Neurones

(2009) Andrew J. Smith et al.   NEUROTOXICITY RESEARCH

Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease

(2009) Walter Swardfager et al.   PSYCHONEUROENDOCRINOLOGY

Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior

(2008) Maïté Moreau et al.   BRAIN BEHAVIOR AND IMMUNITY

Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells

(2008) Yadollah Omidi et al.   CELL BIOCHEMISTRY AND FUNCTION

Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer

(2008) Andrew H. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors

(2008) Izumi Yawata et al.   LIFE SCIENCES

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Homeostasis of glutamate in brain fluids: An accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies

(2008) V.I. Teichberg et al.   NEUROSCIENCE

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

(2007) Lêda S.B. Garcia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY