Preparing the ground for tissue regeneration: from mechanism to therapy

Complete cardiac regeneration in a mouse model of myocardial infarction

(2016) Bernhard Johannes Haubner et al.   Aging-US

The dynamic lives of macrophage and dendritic cell subsets in atherosclerosis

(2014) Parésa L. Taghavie-Moghadam et al.   Annals of the New York Academy of Sciences

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Activation of the Epidermal Growth Factor Receptor in Macrophages Regulates Cytokine Production and Experimental Colitis

(2014) N. Lu et al.   JOURNAL OF IMMUNOLOGY

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Cell therapy for cardiac repair—lessons from clinical trials

(2014) Atta Behfar et al.   Nature Reviews Cardiology

Immune system modulation of kidney regeneration—mechanisms and implications

(2014) Hans-Joachim Anders   Nature Reviews Nephrology

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat

(2014) J. Hu et al.   SCIENCE

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Toward the Development of a Global Induced Pluripotent Stem Cell Library

(2013) Marc Turner et al.   Cell Stem Cell

Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo

(2013) Tim Czopka et al.   DEVELOPMENTAL CELL

Dll4 and PDGF-BB Convert Committed Skeletal Myoblasts to Pericytes without Erasing Their Myogenic Memory

(2013) Ornella Cappellari et al.   DEVELOPMENTAL CELL

Mast cell activity in the healing wound: more than meets the eye?

(2013) Brian C. Wulff et al.   EXPERIMENTAL DERMATOLOGY

Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

(2013) Tae–Young Choi et al.   GASTROENTEROLOGY

Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish

(2013) Jianbo He et al.   GASTROENTEROLOGY

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion

(2013) Michael J. Williams et al.   GASTROENTEROLOGY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Intramyocardial Autologous Cell Engraftment in Patients with Ischaemic Heart Failure: A Meta-Analysis of Randomised Controlled Trials

(2013) Kang Cheng et al.   Heart Lung and Circulation

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Mast cells, glia and neuroinflammation: partners in crime?

(2013) Stephen D. Skaper et al.   IMMUNOLOGY

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa

(2013) L. Egea et al.   JOURNAL OF IMMUNOLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Regulatory T cells in nonlymphoid tissues

(2013) Dalia Burzyn et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Stromal cells in tissue homeostasis: balancing regeneration and fibrosis

(2013) Ton J. Rabelink et al.   Nature Reviews Nephrology

Renal progenitors: an evolutionary conserved strategy for kidney regeneration

(2013) Paola Romagnani et al.   Nature Reviews Nephrology

Eosinophils secrete IL-4 to facilitate liver regeneration

(2013) Y. P. S. Goh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

(2013) T. G. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

(2013) F. K. Swirski et al.   SCIENCE

The Rise of Cell Therapy Trials for Stroke: Review of Published and Registered Studies

(2013) Paulo Henrique Rosado-de-Castro et al.   STEM CELLS AND DEVELOPMENT

New tides: using zebrafish to study renal regeneration

(2013) Kristen K. McCampbell et al.   Translational Research

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

(2013) Anat London et al.   Frontiers in Cellular Neuroscience

Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart

(2012) Nicola Smart et al.   Annals of the New York Academy of Sciences

Cardiac Regenerative Capacity and Mechanisms

(2012) Kazu Kikuchi et al.   Annual Review of Cell and Developmental Biology

Regulation of Cardiac MicroRNAs by Bone Marrow Mononuclear Cell Therapy in Myocardial Infarction

(2012) Kazuma Iekushi et al.   CIRCULATION

Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish

(2012) Luke Pase et al.   CURRENT BIOLOGY

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

(2012) Regina Español–Suñer et al.   GASTROENTEROLOGY

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

(2012) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats

(2012) Lin Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

(2012) Sophie Dulauroy et al.   NATURE MEDICINE

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile

(2012) Alexander R. Pinto et al.   PLoS One

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration

(2012) Marielle Saclier et al.   STEM CELLS

Sterile inflammation – do innate lymphoid cell subsets play a role?

(2012) Shane Russell   Frontiers in Immunology

Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

(2011) Maliha A. Alikhan et al.   AMERICAN JOURNAL OF PATHOLOGY

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

(2011) Michael A. Gibbons et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

(2011) Ting-Ting Tang et al.   BASIC RESEARCH IN CARDIOLOGY

Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132

(2011) Rajesh Katare et al.   CIRCULATION RESEARCH

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Emerging roles for integrated imaging modalities in cardiovascular cell-based therapeutics: a clinical perspective

(2011) Peter J. Psaltis et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair

(2011) Ravid Shechter et al.   PLoS One

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

A Multicellular Approach Forms a Significant Amount of Tissue-Engineered Small Intestine in the Mouse

(2011) Frédéric G. Sala et al.   TISSUE ENGINEERING PART A

Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

(2011) A. Dellavalle et al.   Nature Communications

Regulatory interactions between muscle and the immune system during muscle regeneration

(2010) James G. Tidball et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Perivascular Ancestors of Adult Multipotent Stem Cells

(2010) Mirko Corselli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury

(2010) Haiyan Lu et al.   FASEB JOURNAL

Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response

(2010) Y. N. Kallis et al.   GUT

Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

(2010) Begoña Ochoa et al.   HEPATOLOGY

Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype

(2010) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Barriers to the successful treatment of liver disease by hepatocyte transplantation

(2010) Kyle A. Soltys et al.   JOURNAL OF HEPATOLOGY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

CSF-1, IGF-1, and the control of postnatal growth and development

(2010) Deborah J. Gow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

(2010) David C. Hay et al.   Stem Cell Research

An Overview of Methods for the In Vivo Evaluation of Tissue-Engineered Skin Constructs

(2010) Gerwen Lammers et al.   TISSUE ENGINEERING PART B-REVIEWS

Impact of ageing on muscle cell regeneration

(2009) Silvia Carosio et al.   AGEING RESEARCH REVIEWS

Perivascular multi-lineage progenitor cells in human organs: Regenerative units, cytokine sources or both?

(2009) Chien-Wen Chen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-10 From Transplanted Bone Marrow Mononuclear Cells Contributes to Cardiac Protection After Myocardial Infarction

(2008) Jana S. Burchfield et al.   CIRCULATION RESEARCH

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology