Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells

(2017) Jin-Hua Chi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway

(2017) Zhengmao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

(2017) Zhantao Deng et al.   International Journal of Nanomedicine

Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation

(2017) Chenggui Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

(2017) Xiangrong Chen et al.   Journal of Neuroinflammation

Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury

(2017) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

Downregulation of USP4 Promotes Activation of Microglia and Subsequent Neuronal Inflammation in Rat Spinal Cord After Injury

(2017) Xingjie Jiang et al.   NEUROCHEMICAL RESEARCH

Apamin inhibits TNF-α- and IFN-γ-induced inflammatory cytokines and chemokines via suppressions of NF-κB signaling pathway and STAT in human keratinocytes

(2017) Woon-Hae Kim et al.   Pharmacological Reports

Docosahexaenoic acid attenuates LPS-stimulated inflammatory response by regulating the PPARγ/NF-κB pathways in primary bovine mammary epithelial cells

(2017) Xuexiu He et al.   RESEARCH IN VETERINARY SCIENCE

The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention

(2017) Hangzhe Xu et al.   NEURAL PLASTICITY

Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats

(2017) Jin Jiang et al.   Frontiers in Molecular Neuroscience

iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53

(2017) Harumasa Nakazawa et al.   PLoS One

Low-level laser facilitates alternatively activated macrophage/microglia polarization and promotes functional recovery after crush spinal cord injury in rats

(2017) Ji Wei Song et al.   Scientific Reports

Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1

(2017) Kuo-Cheng Lan et al.   Scientific Reports

Inhibition of Endoplasmic Reticulum Stress Preserves the Integrity of Blood-Spinal Cord Barrier in Diabetic Rats Subjected to Spinal Cord Injury

(2017) Zili He et al.   Scientific Reports

HDAC3 inhibition ameliorates spinal cord injury by immunomodulation

(2017) Tomoharu Kuboyama et al.   Scientific Reports

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

(2016) Niek G.J. Leus et al.   BIOCHEMICAL PHARMACOLOGY

FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells

(2016) Gang Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning

(2016) Hongbo Yi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock

(2016) Ted Bambakidis et al.   JOURNAL OF NEUROTRAUMA

Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury

(2016) Hemant Kumar et al.   MOLECULAR NEUROBIOLOGY

Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

(2016) Xiaolan Cui et al.   Cell Death & Disease

Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Xiang-Sheng Zhang et al.   Cell Death & Disease

Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation

(2015) Meng-Meng Ji et al.   Autophagy

Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion

(2015) Satoshi Suda et al.   BRAIN RESEARCH

JAK/STAT pathway regulation of GABA A receptor expression after differing severities of experimental TBI

(2015) Daniel J. Raible et al.   EXPERIMENTAL NEUROLOGY

The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review)

(2015) Joseph Sinkovics   INTERNATIONAL JOURNAL OF ONCOLOGY

Exendin-4 Enhances Motor Function Recovery via Promotion of Autophagy and Inhibition of Neuronal Apoptosis After Spinal Cord Injury in Rats

(2015) Hao-Tian Li et al.   MOLECULAR NEUROBIOLOGY

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential

(2015) Tianci Chu et al.   Regenerative Medicine

Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder

(2014) C. Brad Wilson et al.   BEHAVIOURAL BRAIN RESEARCH

The Effects of Fludarabine on Rat Cerebral Ischemia

(2014) Qian Xu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice

(2014) Qian Zhang et al.   MOLECULAR NEUROBIOLOGY

Valproic Acid: A New Candidate of Therapeutic Application for the Acute Central Nervous System Injuries

(2014) Sheng Chen et al.   NEUROCHEMICAL RESEARCH

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Valproic Acid Protects Motor Neuron Death by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Cytochrome C Release after Spinal Cord Injury

(2013) Jee Y. Lee et al.   JOURNAL OF NEUROTRAUMA

HMGB1 Contributes to Regeneration After Spinal Cord Injury in Adult Zebrafish

(2013) Ping Fang et al.   MOLECULAR NEUROBIOLOGY

Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways

(2013) Sun Young Park et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury

(2011) C. Penas et al.   NEUROSCIENCE