HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication

Creation of a long-acting nanoformulated dolutegravir

(2018) Brady Sillman et al.   Nature Communications

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

(2017) Divya Prakash Gnanadhas et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotype, function, and differentiation potential of human monocyte subsets

(2017) Lisa B. Boyette et al.   PLoS One

Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens

(2016) S R Larson et al.   CELL DEATH AND DIFFERENTIATION

Elie Metchnikoff, the Man and the Myth

(2016) Siamon Gordon   Journal of Innate Immunity

Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS

(2016) Arevik Mosoian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neuropharmacologic Approaches to Restore the Brain’s Microenvironment

(2016) Weizhe Li et al.   Journal of Neuroimmune Pharmacology

Development and characterization of a long-acting nanoformulated abacavir prodrug

(2016) Dhirender Singh et al.   Nanomedicine

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

(2016) Gang Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

HIV-1 cellular and tissue replication patterns in infected humanized mice

(2016) Mariluz Araínga et al.   Scientific Reports

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

(2016) Rafal Kaminski et al.   Scientific Reports

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

(2016) Brennan S. Dirk et al.   Scientific Reports

Anti-HIV Drug-Combination Nanoparticles Enhance Plasma Drug Exposure Duration as Well as Triple-Drug Combination Levels in Cells Within Lymph Nodes and Blood in Primates

(2015) Jennifer P. Freeling et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression

(2015) Sina Gordan et al.   IMMUNOLOGICAL REVIEWS

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate

(2015) Pehuén Pereyra Gerber et al.   JOURNAL OF CELL BIOLOGY

The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking

(2015) Audrey Dumas et al.   JOURNAL OF CELL BIOLOGY

Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial

(2015) James E. Scriven et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of Heme Oxygenase-1 Deficiency and Associated Glutamate-Mediated Neurotoxicity Is a Highly Conserved HIV Phenotype of Chronic Macrophage Infection That Is Resistant to Antiretroviral Therapy

(2015) Alexander J. Gill et al.   JOURNAL OF VIROLOGY

Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers

(2015) Wendy E. Walker et al.   JOURNAL OF VIROLOGY

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

(2015) Maria Pino et al.   Retrovirology

Early hematopoiesis and macrophage development

(2015) Kathleen E. McGrath et al.   SEMINARS IN IMMUNOLOGY

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

(2015) Hsin-Kai Liao et al.   Nature Communications

Hepcidin and Host Defense against Infectious Diseases

(2015) Kathryn Michels et al.   PLoS Pathogens

Asymptomatic HIV-infected Individuals on Antiretroviral Therapy Exhibit Impaired Lung CD4+T-Cell Responses to Mycobacteria

(2014) Kondwani C. Jambo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

Interaction of HIV-1 Nef Protein with the Host Protein Alix Promotes Lysosomal Targeting of CD4 Receptor

(2014) Nathaly A. Amorim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significant Virus Replication in Langerhans Cells following Application of HIV to Abraded Skin: Relevance to Occupational Transmission of HIV

(2014) T. Kawamura et al.   JOURNAL OF IMMUNOLOGY

Characterization of Platelet-Monocyte Complexes in HIV-1-Infected Individuals: Possible Role in HIV-Associated Neuroinflammation

(2014) M. V. Singh et al.   JOURNAL OF IMMUNOLOGY

Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance

(2014) D. Guo et al.   JOURNAL OF VIROLOGY

Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis

(2014) T. DeFalco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block

(2014) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction

(2014) A Nicole Desch et al.   Nature Communications

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Granulocyte Macrophage-Colony Stimulating Factor Induced Zn Sequestration Enhances Macrophage Superoxide and Limits Intracellular Pathogen Survival

(2013) Kavitha Subramanian Vignesh et al.   IMMUNITY

HIV-1 Infection of Macrophages Dysregulates Innate Immune Responses to Mycobacterium tuberculosis by Inhibition of Interleukin-10

(2013) Gillian S. Tomlinson et al.   JOURNAL OF INFECTIOUS DISEASES

Small magnetite antiretroviral therapeutic nanoparticle probes for MRI of drug biodistribution

(2013) Dongwei Guo et al.   Nanomedicine

Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections

(2013) Pavan Puligujja et al.   Nanomedicine-Nanotechnology Biology and Medicine

Down-Regulation of CTLA-4 by HIV-1 Nef Protein

(2013) Mohamed El-Far et al.   PLoS One

Plasmacytoid dendritic cells: Key players in viral infections and autoimmune diseases

(2013) Karina Santana-de Anda et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Nature, nurture and HIV: The effect of producer cell on viral physiology

(2013) Sergey Iordanskiy et al.   VIROLOGY

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

(2012) Prasanta K. Dash et al.   AIDS

The embryonic origins of erythropoiesis in mammals

(2012) M. H. Baron et al.   BLOOD

The GM-CSF receptor family: Mechanism of activation and implications for disease

(2012) Timothy R. Hercus et al.   GROWTH FACTORS

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

(2012) Georgette Kanmogne et al.   International Journal of Nanomedicine

Characterization of resident and migratory dendritic cells in human lymph nodes

(2012) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Re(de)fining the dendritic cell lineage

(2012) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice during Tumor-Specific Antibody Immunotherapy

(2011) P. Hubert et al.   CANCER RESEARCH

Cytokines and the regulation of fungus-specific CD4 T cell differentiation

(2011) Vanessa Espinosa et al.   CYTOKINE

Dimethyl Fumarate, an Immune Modulator and Inducer of the Antioxidant Response, Suppresses HIV Replication and Macrophage-Mediated Neurotoxicity: A Novel Candidate for HIV Neuroprotection

(2011) Stephanie A. Cross et al.   JOURNAL OF IMMUNOLOGY

Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection

(2011) Irena Kadiu et al.   Journal of Neuroimmune Pharmacology

Macrophage Bridging Conduit Trafficking of HIV-1 Through the Endoplasmic Reticulum and Golgi Network

(2011) Irena Kadiu et al.   JOURNAL OF PROTEOME RESEARCH

How does the oxidative burst of macrophages kill bacteria? Still an open question

(2011) James M. Slauch   MOLECULAR MICROBIOLOGY

Macrophage endocytic trafficking of antiretroviral nanoparticles

(2011) Irena Kadiu et al.   Nanomedicine

Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments

(2010) J. Mazzolini et al.   BLOOD

Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood–brain barrier and infection by HIV: Implications for NeuroAIDS

(2010) Clarisa M. Buckner et al.   CELLULAR IMMUNOLOGY

Unmet therapeutic needs in the new era of combination antiretroviral therapy for HIV-1

(2010) B. Taiwo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages

(2010) Ari S. Nowacek et al.   JOURNAL OF CONTROLLED RELEASE

Development of a HIV-1 lipopeptide antigen pulsed therapeutic dendritic cell vaccine

(2010) Amanda Cobb et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

Peroxisome proliferator-activated receptor-γ activation suppresses HIV-1 replication in an animal model of encephalitis

(2009) Raghava Potula et al.   AIDS

Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution

(2009) Ashwin Balagopal et al.   AIDS

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

HIV-1 Nef Promotes Endocytosis of Cell Surface MHC Class II Molecules via a Constitutive Pathway

(2009) A. Chaudhry et al.   JOURNAL OF IMMUNOLOGY

Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS

(2009) H. Dou et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Differential Role of Autophagy in CD4 T Cells and Macrophages during X4 and R5 HIV-1 Infection

(2009) Lucile Espert et al.   PLoS One

miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1

(2009) Tzu-Ling Sung et al.   PLoS Pathogens

Amplification of the signal transducer and activator of transcription I signaling pathway and its association with apoptosis in monocytes from HIV-infected patients

(2008) Abdulkarim Alhetheel et al.   AIDS

Differential impact of adherence on long-term treatment response among naive HIV-infected individuals

(2008) Viviane D Lima et al.   AIDS

Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation

(2008) S. A. Beers et al.   BLOOD

The Emergence of Hematopoietic Stem Cells Is Initiated in the Placental Vasculature in the Absence of Circulation

(2008) Katrin E. Rhodes et al.   Cell Stem Cell

Human Immunodeficiency Virus Infection Alters Tumor Necrosis Factor Alpha Production via Toll-Like Receptor-Dependent Pathways in Alveolar Macrophages and U1 Cells

(2008) M. Q. Nicol et al.   JOURNAL OF VIROLOGY

HIV-1 Nef Induces a Rab11-Dependent Routing of Endocytosed Immune Costimulatory Proteins CD80 and CD86 to the Golgi

(2008) Ashutosh Chaudhry et al.   TRAFFIC

HIV-1 Infection and the PPARγ-Dependent Control of Adipose Tissue Physiology

(2008) Marta Giralt et al.   PPAR Research

Real-Time Visualization of HIV-1 GAG Trafficking in Infected Macrophages

(2008) Karine Gousset et al.   PLoS Pathogens

Human macrophages support persistent transcription from unintegrated HIV-1 DNA

(2007) Jeremy Kelly et al.   VIROLOGY