bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression

No Need for Constant Help: Human IgG2 Antibodies Have an Autonomous Agonistic Activity for Immunotherapy of Cancer

(2015) Anja Lux et al.   CANCER CELL

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

(2015) David J. DiLillo et al.   CELL

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Intravenous immunoglobulin in neurology—mode of action and clinical efficacy

(2015) Jan D. Lünemann et al.   Nature Reviews Neurology

Two-faced immunology—from osteogenesis to bone resorption

(2015) Hiroshi Takayanagi   Nature Reviews Rheumatology

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

(2015) Benjamin M. Fiebiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities

(2015) Falk Nimmerjahn et al.   TRENDS IN IMMUNOLOGY

Immune complexes regulate bone metabolism through FcRγ signalling

(2015) Takako Negishi-Koga et al.   Nature Communications

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy

(2014) Christian P. Pallasch et al.   CELL

Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo

(2014) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

(2014) Nuray Gül et al.   JOURNAL OF CLINICAL INVESTIGATION

Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between Fc RI and Fc RIV

(2014) M. A. Otten et al.   JOURNAL OF IMMUNOLOGY

Differential Contribution of Three Activating IgG Fc Receptors (Fc RI, Fc RIII, and Fc RIV) to IgG2a- and IgG2b-Induced Autoimmune Hemolytic Anemia in Mice

(2014) L. Baudino et al.   JOURNAL OF IMMUNOLOGY

Intravenous Immunoglobulin Treatment in Humans Suppresses Dendritic Cell Function via Stimulation of IL-4 and IL-13 Production

(2014) A. S. W. Tjon et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

(2014) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Dendritic cells and macrophages in the kidney: a spectrum of good and evil

(2014) Natasha M. Rogers et al.   Nature Reviews Nephrology

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

(2014) Valentin Goede et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intravenous immunoglobulin-induced IL-33 is insufficient to mediate basophil expansion in autoimmune patients

(2014) Meenu Sharma et al.   Scientific Reports

A Humanized Mouse Identifies the Bone Marrow as a Niche with Low Therapeutic IgG Activity

(2014) Anja Lux et al.   Cell Reports

Bone- and Cartilage-Protective Effects of a Monoclonal Antibody Against Colony-Stimulating Factor 1 Receptor in Experimental Arthritis

(2014) Myew-Ling Toh et al.   Arthritis & Rheumatology

Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

(2013) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

The high-affinity human IgG receptor Fc RI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

(2013) D. A. Mancardi et al.   BLOOD

Neutrophils mediate antibody-induced antitumor effects in mice

(2013) M. Albanesi et al.   BLOOD

FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs

(2013) Ann L. White et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells

(2013) Amir H. Massoud et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell–independent B cell activation induces immunosuppressive sialylated IgG antibodies

(2013) Constanze Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging

(2013) Fabricio Montalvao et al.   JOURNAL OF CLINICAL INVESTIGATION

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Inflammatory monocytes and Fc  receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

(2013) M. Seeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor activities of agonistic anti-TNFR antibodies require differential Fc RIIB coengagement in vivo

(2013) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid Dendritic Cells, Interferon Signaling, and FcγR Contribute to Pathogenesis and Therapeutic Response in Childhood Immune Thrombocytopenia

(2013) Kartik Sehgal et al.   Science Translational Medicine

Tissue macrophage heterogeneity: issues and prospects

(2013) Siamon Gordon et al.   Seminars in Immunopathology

Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fc  receptor for the amelioration of experimental ITP

(2012) D. Leontyev et al.   BLOOD

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Low level of FcγRIII expression on murine natural killer cells

(2012) Markus Biburger et al.   IMMUNOLOGY LETTERS

Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs

(2012) Carolin M. Oefner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Of Mice and Men: The Need for Humanized Mouse Models to Study Human IgG Activity in Vivo

(2012) Anja Lux et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Fc RIII (CD16) and Fc RI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma

(2012) M. Albanesi et al.   JOURNAL OF IMMUNOLOGY

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

(2012) P. Mark Hogarth et al.   NATURE REVIEWS DRUG DISCOVERY

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc  receptor engagement

(2012) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse model recapitulating human Fc  receptor structural and functional diversity

(2012) P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin G dimers and immune complexes are dispensable for the therapeutic efficacy of intravenous immune globulin in murine immune thrombocytopenia

(2012) Tony Tremblay et al.   TRANSFUSION

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

(2011) Nicholas S. Wilson et al.   CANCER CELL

Monocyte Subsets Responsible for Immunoglobulin G-Dependent Effector Functions In Vivo

(2011) Markus Biburger et al.   IMMUNITY

Dendritic Cell and Macrophage Heterogeneity In Vivo

(2011) Daigo Hashimoto et al.   IMMUNITY

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

(2011) Thorsten B. Feyerabend et al.   IMMUNITY

Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody

(2011) A. L. White et al.   JOURNAL OF IMMUNOLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Intravenous immunoglobulin therapy in rheumatic diseases

(2011) Jagadeesh Bayry et al.   Nature Reviews Rheumatology

Fc  receptor IIB (Fc RIIB) maintains humoral tolerance in the human immune system in vivo

(2011) A. Baerenwaldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes

(2010) J.-F. Seite et al.   BLOOD

Therapeutic Antibodies to Human L1CAM: Functional Characterization and Application in a Mouse Model for Ovarian Carcinoma

(2010) S. Wolterink et al.   CANCER RESEARCH

Mechanisms of IVIG Efficacy in Chronic Inflammatory Demyelinating Polyneuropathy

(2010) Björn Tackenberg et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A requirement for FcγR in antibody-mediated bacterial toxin neutralization

(2010) Nareen Abboud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fc RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

(2010) F. Nimmerjahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model

(2009) S.-Y. Wang et al.   BLOOD

Clinical applications of intravenous immunoglobulins (IVIg) - beyond immunodeficiencies and neurology

(2009) H.-P. Hartung et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

In vivodepletion of CD4+FOXP3+Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcγRIII+phagocytes

(2009) Yulius Y. Setiady et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impaired inhibitory Fc  receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy

(2009) B. Tackenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What is the contents of the magic draft IVIg?

(2008) Jean-François Seite et al.   AUTOIMMUNITY REVIEWS

Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation

(2008) S. A. Beers et al.   BLOOD

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc RI, Fc RIII, and Fc RIV

(2008) V. Minard-Colin et al.   BLOOD

A Polymorphism in the Complement Component C1qA Correlates with Prolonged Response Following Rituximab Therapy of Follicular Lymphoma

(2008) E. Racila et al.   CLINICAL CANCER RESEARCH

FcγRIV is a mouse IgE receptor that resembles macrophage FcεRI in humans and promotes IgE-induced lung inflammation

(2008) David A. Mancardi et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Trastuzumab-Based Therapy in Patients With HER-2/neu–Positive Metastatic Breast Cancer

(2008) Antonino Musolino et al.   JOURNAL OF CLINICAL ONCOLOGY

A novel subset of NK cells expressing high levels of inhibitory FcγRIIB modulating antibody-dependent function

(2008) Charles-Antoine Dutertre et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE