Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

Accelerated ageing of the lung in COPD: new concepts

(2015) Nicolas Mercado et al.   THORAX

STOP accelerating lung aging for the treatment of COPD

(2014) Kazuhiro Ito et al.   EXPERIMENTAL GERONTOLOGY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Targeted Deletion of Jun/AP-1 in Alveolar Epithelial Cells Causes Progressive Emphysema and Worsens Cigarette Smoke–Induced Lung Inflammation

(2012) Narsa M. Reddy et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR inhibitors in cancer therapy

(2012) Yekaterina Y. Zaytseva et al.   CANCER LETTERS

Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation

(2012) Yoshiki Kobayashi et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Current management of lymphangioleiomyomatosis

(2011) Camille Taillé et al.   CURRENT OPINION IN PULMONARY MEDICINE

Nortriptyline Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase- 

(2011) N. Mercado et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

p38 Mitogen-Activated Protein Kinase-  Inhibition by Long-Acting  2 Adrenergic Agonists Reversed Steroid Insensitivity in Severe Asthma

(2011) N. Mercado et al.   MOLECULAR PHARMACOLOGY

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy

(2010) O. Yogev et al.   CANCER RESEARCH

Mechanisms and resistance in glucocorticoid control of inflammation

(2010) Peter J. Barnes   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

(2009) John A. Marwick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

Molecular Mechanisms of Corticosteroid Resistance

(2008) Ian M. Adcock et al.   CHEST