Article
Biochemistry & Molecular Biology
Hina Agraval, Jiten R. Sharma, Nutan Prakash, Umesh C. S. Yadav
Summary: This study elucidates the mechanism of cigarette smoke-induced COX-2-mediated EMT in airway epithelial cells. Fisetin reverses EMT induced by smoke by inhibiting COX-2, suggesting that it could be an effective drug candidate for treating smoke-induced lung dysfunction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Sun Young Jung, Gun-Dong Kim, Dae Woon Choi, Dong-Uk Shin, Ji-Eun Eom, Seung Yong Kim, Ok Hee Chai, Hyun-Jin Kim, So-Young Lee, Hee Soon Shin
Summary: The study found that Epilobium species extract can inhibit inflammatory cell recruitment and symptoms in COPD mice, as well as attenuate inflammatory gene expression by suppressing MAPKs and NF kappa B activity. Additionally, identified phytochemical constituents of Epilobium species extract showed anti-inflammatory effects.
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Article
Biochemistry & Molecular Biology
Mun-Ock Kim, Jae-Won Lee, Jae Kyoung Lee, Yu Na Song, Eun Sol Oh, Hyunju Ro, Dahye Yoon, Yun-Hwa Jeong, Ji-Yoon Park, Sung-Tae Hong, Hyung Won Ryu, Su Ui Lee, Dae Young Lee
Summary: Korean black ginseng extract inhibits airway inflammation and mucus secretion by decreasing the activation of TAK1, suggesting it could be a potential adjuvant in the treatment of airway inflammatory diseases caused by cigarette smoke.
Article
Biochemistry & Molecular Biology
Pritam Saha, Sneha Durugkar, Siddhi Jain, P. A. Shantanu, Samir R. Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V. G. M. Naidu
Summary: The study found that PIP treatment can protect cells from CSE-induced lung epithelial cell death. PIP treatment can restore epithelial markers and reduce mesenchymal and inflammatory markers in both in vitro and in vivo models. PIP treatment can improve altered lung function in mice induced by CS exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen
Summary: DHQ significantly reverses cigarette smoke-induced ferroptosis via a Nrf2-dependent signaling pathway, exerting protective effects in both in vivo mouse models and in vitro cell cultures.
Article
Chemistry, Multidisciplinary
Xuan Ma, Jinzhao Zhang, Shengyu Wang, Yaming Li, Ibrahim Abdel Aziz Ibrahim, Xin Diao
Summary: In this study, the ameliorative effect of paclobutrazol against chronic cigarette smoke-induced COPD in rats was assessed. Results showed that paclobutrazol increased body weight, improved respiratory function, and decreased inflammation in rats exposed to secondhand smoke.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
Eun Bok Baek, Jin-Hyung Rho, Eunhye Jung, Chang-Seob Seo, Jin-Hee Kim, Hyo-Jung Kwun
Summary: The study demonstrates that PJH can effectively prevent respiratory inflammation and airway remodeling in a mouse model of chronic obstructive pulmonary disease induced by cigarette smoke and lipopolysaccharide.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Immunology
Lijing Wang, Qiong Chen, Qiao Yu, Jian Xiao, Hongjun Zhao
Summary: In this study, it was found that exosomes derived from cigarette smoke extract-treated mouse airway epithelial cells promoted M1 macrophage polarization by upregulating TREM-1 expression, thereby aggravating the development of COPD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Rosalia Gagliardo, Fabio Bucchieri, Angela Marina Montalbano, Giusy Daniela Albano, Delphine Gras, Alberto Fucarino, Roberto Marchese, Giulia Anzalone, Chiara Lo Nigro, Pascal Chanez, Mirella Profita
Summary: The airway epithelium plays a critical role in the pathophysiology of COPD, with dysregulation of Oct4, CD146, and CD105 expression induced by cigarette smoke exposure potentially exacerbating airway epithelial dysfunction and contributing to disease progression.
Article
Immunology
Li Che, Zhefan Xie, Guangshu Chen, Wei Zhang, Tingting Xia, Jiaxin Lin, Wenzhi Luo, Li Chen, Wenguang Yin, Xingdong Cai, Shengming Liu
Summary: This study found that the expression of RELM beta and autophagy genes is significantly increased in the lung tissue of COPD patients. RELM beta promotes airway inflammation in COPD by activating autophagy and increasing the expression of inflammatory cytokines. Furthermore, RELM beta mediates signal transduction by binding to the cell membrane receptor TLR4.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Plant Sciences
Eun Bok Baek, Yu Jin Kim, Jin-Hyung Rho, Eun-Ju Hong, Mee-Young Lee, Hyo-Jung Kwun
Summary: The study found that Gyeji-tang significantly suppressed lung inflammation and airway remodeling induced by cigarette smoke and lipopolysaccharide exposure, suggesting its potential therapeutic effect on chronic obstructive pulmonary disease.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Norio Yamamoto, Keiko Kan-o, Miyoko Tatsuta, Yumiko Ishii, Tomohiro Ogawa, Seiji Shinozaki, Satoru Fukuyama, Yoichi Nakanishi, Koichiro Matsumoto
Summary: Recent clinical studies have shown that inhalation of incense smoke may cause impaired lung function and asthma. Experimental evidence suggests that incense smoke exposure can lead to airway hyperresponsiveness, disruption of epithelial tight junction proteins in the lungs, and damage to bronchial epithelial barrier function. Antioxidants may be effective in treating incense smoke-induced airway dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Gabriele De Rubis, Keshav Raj Paudel, Bikash Manandhar, Sachin Kumar Singh, Gaurav Gupta, Raniya Malik, Jessie Shen, Aniss Chami, Ronan MacLoughlin, Dinesh Kumar Chellappan, Brian Gregory George Oliver, Philip Michael Hansbro, Kamal Dua
Summary: Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease caused by chronic cigarette smoke exposure. Traditional treatments focus on reducing symptoms, but fail to regulate oxidative stress and inflammation, resulting in lung damage. This study explores the potential of agarwood essential oil nanoemulsion (agarwood-NE) as a promising treatment option for COPD by demonstrating its antioxidant and anti-inflammatory effects. The findings show that agarwood-NE successfully counters the pro-inflammatory effects of cigarette smoke extract by reducing the expression of pro-inflammatory cytokines and inducing the expression of anti-inflammatory mediators and antioxidant genes.
Article
Engineering, Biomedical
Bao-Ping Tian, Fangyuan Li, Ruiqing Li, Xi Hu, Tian-Wen Lai, Jingxiong Lu, Yun Zhao, Yang Du, Zeyu Liang, Chen Zhu, Wei Shao, Wen Li, Zhi-Hua Chen, Xiaolian Sun, Xiaoyuan Chen, Songmin Ying, Daishun Ling, Huahao Shen
Article
Critical Care Medicine
Tianwen Lai, Baoping Tian, Chao Cao, Yue Hu, Jiesen Zhou, Yong Wang, Yanping Wu, Zhouyang Li, Xuchen Xu, Min Zhang, Feng Xu, Yuan Cao, Min Chen, Dong Wu, Bin Wu, Chen Dong, Wen Li, Songmin Ying, Zhihua Chen, Huahao Shen
Article
Physiology
Tianwen Lai, Mindan Wu, Chao Zhang, Luanqing Che, Feng Xu, Yong Wang, Yanping Wu, Nanxia Xuan, Chao Cao, Xufei Du, Bin Wu, Wen Li, Songmin Ying, Huahao Shen, Zhihua Chen
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Weina Huang, Libin Chen, Ning Xu, Linfeng Wang, Fang Liu, Shiyi He, Tianwen Lai, Xueqin Chen
BIOSCIENCE REPORTS
(2019)
Review
Respiratory System
Haipin Chen, Zhouyang Li, Lingling Dong, Yinfang Wu, Huahao Shen, Zhihua Chen
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2019)
Article
Cell Biology
Yin-Fang Wu, Zhou-Yang Li, Ling-Ling Dong, Wei-Jie Li, Yan-Ping Wu, Jing Wang, Hai-Pin Chen, Hui-Wen Liu, Miao Li, Ci-Liang Jin, Hua-Qiong Huang, Song-Min Ying, Wen Li, Hua-Hao Shen, Zhi-Hua Chen
Article
Respiratory System
Tianwen Lai, Xiaoxia Wen, Dong Wu, Guomei Su, Yun Gao, Cuifen Chen, Weiquan Wu, Yingying Lv, Zhanghui Chen, Quanchao Lv, Wen Li, Dongming Li, Min Chen, Bin Wu
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2019)
Correction
Engineering, Biomedical
Bao-ping Tian, Fangyuan Li, Ruiqing Li, Xi Hu, Tian-wen Lai, Jingxiong Lu, Yun Zhao, Yang Du, Zeyu Liang, Chen Zhu, Wei Shao, Wen Li, Zhi-hua Chen, Xiaolian Sun, Xiaoyuan Chen, Songmin Ying, Daishun Ling, Huahao Shen
Article
Respiratory System
Yanping Wu, Haixia Chen, Nanxia Xuan, Lingren Zhou, Yinfang Wu, Chen Zhu, Miao Li, Qingyu Weng, Jiaxin Shen, Hao Zhang, Bin Zhang, Fen Lan, Lixia Xia, Xuefang Xiong, Zhouyang Li, Yun Zhao, Mindan Wu, Songmin Ying, Wen Li, Huahao Shen, Zhihua Chen
Article
Respiratory System
Wen Li, Yinfang Wu, Yun Zhao, Zhouyang Li, Haixia Chen, Lingling Dong, Huiwen Liu, Min Zhang, Yanping Wu, Jiesen Zhou, Juan Xiong, Yue Hu, Wen Hua, Bin Zhang, Minzhi Qiu, Qing-ling Zhang, Chunhua Wei, Mingchun Wen, Jing Han, Xiaobo Zhou, Weiliang Qiu, Fugui Yan, Huaqiong Huang, Songmin Ying, Augustine M. K. Choi, Huahao Shen, Zhihua Chen
Review
Respiratory System
Mindan Wu, Shuyi Wang, Qingyu Weng, Haixia Chen, Jiaxin Shen, Zhouyang Li, Yanping Wu, Yun Zhao, Miao Li, Yinfang Wu, Shiyi Yang, Qichuan Zhang, Huahao Shen
Summary: This study found that prenatal and postnatal exposure to Bisphenol A (BPA) was associated with an increased risk of childhood asthma. However, only postnatal and early gestational exposure (at 16 weeks) to BPA could induce the risk of childhood wheeze, while late gestational exposure (at 26 weeks) did not.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Immunology
Hua-Qiong Huang, Na Li, Dan-Yang Li, Du Jing, Zheng-Yuan Liu, Xu-Chen Xu, Hai-Pin Chen, Ling-Ling Dong, Min Zhang, Song-Min Ying, Wen Li, Hua-Hao Shen, Zhou-Yang Li, Zhi-Hua Chen
Summary: This study demonstrates that autophagy plays a crucial role in the development of bronchitis-like airway inflammation in a COPD mouse model induced by CS. Inhibition of autophagy, such as with 3-MA, can effectively suppress the development of airway inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mindan Wu, Tianwen Lai, Du Jing, Shiyi Yang, Yanping Wu, Zhouyang Li, Yinfang Wu, Yun Zhao, Lingren Zhou, Haipin Chen, Jiaxin Shen, Wen Li, Songmin Ying, Zhihua Chen, Xiaohong Wu, Huahao Shen
Summary: The study showed that increased IL17A expression in the airway epithelium is associated with COPD, and selective knockout of IL17A in the airway epithelium can reduce neutrophilic infiltration, peribronchial inflammation, proinflammatory mediators, and mucus production in a COPD mouse model. This suggests a novel function of airway epithelium-derived IL17A in COPD pathogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Respiratory System
Jie-Sen Zhou, Zhou-Yang Li, Xu-Chen Xu, Yun Zhao, Yong Wang, Hai-Pin Chen, Min Zhang, Yin-Fang Wu, Tian-Wen Lai, Chun-Hong Di, Ling-Ling Dong, Juan Liu, Nan-Xia Xuan, Chen Zhu, Yan-Ping Wu, Hua-Qiong Huang, Fu-Gui Yan, Wen Hua, Yi Wang, Wei-Ning Xiong, Hui Qiu, Tao Chen, Dong Weng, Hui-Ping Li, Xiaobo Zhou, Lie Wang, Fang Liu, Xin Lin, Song-Min Ying, Wen Li, Mitsuru Imamura, Mary E. Choi, Martin R. Stampfli, Augustine M. K. Choi, Zhi-Hua Chen, Hua-Hao Shen
EUROPEAN RESPIRATORY JOURNAL
(2020)