FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma

HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axis

(2016) Mohita Bhagat et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma

(2016) Evanka Madan et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxic and Reoxygenated Microenvironment: Stemness and Differentiation State in Glioblastoma

(2016) Mariana Maier Gaelzer et al.   MOLECULAR NEUROBIOLOGY

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

(2015) Brenda Auffinger et al.   Expert Review of Neurotherapeutics

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

(2015) Hui Xu et al.   Oncotarget

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

(2015) Brenda Auffinger et al.   Expert Review of Neurotherapeutics

A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance

(2015) Khushboo Irshad et al.   PLoS One

Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma

(2014) Daniela Valletta et al.   CARCINOGENESIS

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay

(2014) FRANCESCO MARAMPON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding

(2014) Nathalie Wojtalewicz et al.   PLoS One

Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells

(2013) Murielle Mimeault et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

(2013) Luc G T Morris et al.   NATURE GENETICS

FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells

(2012) B Dikshit et al.   ONCOGENE

Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models

(2011) Sang-Kyun Lim et al.   BMB Reports

The HIF-1-Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth

(2011) F. Pez et al.   CANCER RESEARCH

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis–relapse samples of precursor B-cell acute lymphoblastic leukemia

(2011) C E de Bock et al.   LEUKEMIA