Article
Biochemistry & Molecular Biology
Shangfeng Gao, Junbo Zhou, Zhiyuan Hu, Shicheng Zhang, Yue Wu, Preethi Priyanka Musunuru, Tong Zhang, Liquan Yang, Xiang Luo, Jin Bai, Qingming Meng, Rutong Yu
Summary: This study found that PCIF1 plays a suppressive role in the growth and survival of glioma cells, regulating cell proliferation and apoptosis. Its inhibition of cell cycle progression and induction of apoptosis may be related to changes in cell checkpoint proteins and apoptotic markers. In addition, overexpression of PCIF1 can inhibit tumor growth and prolong the survival time of tumor-bearing mice, and its expression levels are associated with the malignancy of gliomas.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Wen-fang Li, Arin Herkilini, Yu Tang, Ping Huang, Guan-bin Song, Makoto Miyagishi, Vivi Kasim, Shou-rong Wu
Summary: PBX3 is involved in the progression of various cancers, and its silencing leads to p21 upregulation, resulting in increased apoptosis and decreased proliferation and colony formation in colorectal cancer cells. PBX3 is highly expressed in clinical CRC patients, and it regulates tumor growth through the p53/p21 axis.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Lun Gao, Zhang Ye, Jun-Hui Liu, Ji-An Yang, Yong Li, Jia-Yang Cai, Yi-Xuan Wang, Shi-Ao Tong, Gang Deng, Shenqi Zhang, Qian-Xue Chen
Summary: TMCO1 plays a critical role in gliomas and its overexpression predicts poor prognosis. The expression of TMCO1 is associated with glioma grade, and knockdown of TMCO1 inhibits cell proliferation and induces apoptosis, while promoting cell migration and invasion through EMT.
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Immunology
Lei Yang, You-Ling Shi, Yan Ma, Wei-Wei Ren, Guang-Ming Pang, Jiao Liu
Summary: The study revealed that the upregulation of KLF16 expression in OSCC cells, interfering with KLF16 resulted in cell cycle arrest, inhibited cell growth, and promoted cell apoptosis.
Article
Biochemistry & Molecular Biology
Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang
Summary: The study confirmed that NSC139021 effectively inhibited the proliferation of glioblastoma cells and induced apoptosis by regulating the p53 signaling pathway and cell cycle kinase pathway, suggesting a potential therapeutic role in glioblastoma treatment.
Article
Oncology
Jun Zhou, Wanpin Nie, Jiajia Yuan, Zeyu Zhang, Liangliang Mi, Changfa Wang, Ranglang Huang
Summary: GSG2 plays a crucial role in the progression of CCA and its overexpression predicts disease deterioration. Experimental results demonstrate that downregulation of GSG2 inhibits proliferation, promotes apoptosis, arrests cell cycle, and weakens migration in CCA cells.
Article
Oncology
Shangfeng Gao, Zhuang Sha, Junbo Zhou, Yihao Wu, Yunnong Song, Cheng Li, Xuejiao Liu, Tong Zhang, Rutong Yu
Summary: The study found elevated levels of BYSL protein in glioma tissues, and high expression of BYSL promoted tumor cell growth and survival, possibly through its association with RIOK2 and mTOR, and activation of the AKT signaling pathway.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao, Xingchun Gou
Summary: The study showed that CACUL1 overexpression in glioma tissues promoted cell proliferation, suppressed apoptosis, and induced cell cycle arrest. Knockdown of CACUL1 hindered cell proliferation and induced apoptosis in glioblastoma cells, suggesting a potential oncogenic role for CACUL1 in gliomas.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Biology
Mohamed A. Elkady, Ahmed S. Doghish, Ahmed Elshafei, Mostafa M. Elshafey
Summary: miR-567 is downregulated in A549 NSCLC cells, but its upregulation can inhibit cell proliferation, promote apoptosis, induce cell cycle arrest, and act as a tumor suppressor by regulating CDK8 gene expression.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Jakub Rok, Justyna Kowalska, Zuzanna Rzepka, Dominika Stencel, Anna Skorek, Klaudia Banach, Dorota Wrzesniok
Summary: Melanoma is the most dangerous form of skin cancer due to its high mortality, aggressiveness, and low effectiveness of therapy. Previous studies have shown the therapeutic potential of minocycline, doxycycline, and chlortetracycline on melanoma cells. This study aimed to evaluate the cytotoxicity of tigecycline, a third-generation tetracycline, on melanotic and amelanotic melanoma cell lines. The results demonstrated that tigecycline efficiently inhibited the proliferation of both types of melanoma cells, accompanied by dysregulation of the cell cycle, depolarization of the mitochondrial membrane, and alterations in various molecular levels. However, the drug induced apoptosis only in melanotic melanoma cells, while amelanotic cells exhibited resistance and showed increased autophagy marker levels.