Article
Reproductive Biology
Taojie Zhang, Lijuan Zhang, Guoliang Huang, Xiaomeng Hao, Zezheng Liu, Shengdong Huo
Summary: Melatonin regulates the expression of microRNAs in the ovaries, mainly through the STAT3 pathway. The LIN28/let-7b and STAT3/miR-21 axes are involved in cell differentiation, apoptosis, and proliferation.
Article
Biochemistry & Molecular Biology
Dae-Won Lee, Sungho Shin, Jeong-Ho Kim, Cheolju Lee, In Yong Kim, Il-Hoan Oh
Summary: The inhibition of let-7 miRNAs enhances the therapeutic potential of MSCs by promoting cell proliferation, migration, and regenerative processes. It does not alter the fate of MSCs but instead induces functional changes accompanied by changes in proteomics. In addition, let-7-inhibited MSCs promote self-renewal of hematopoietic progenitor cells and enhance capillary formation in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yuchong Zhao, Yun Wang, Wei Chen, Shuya Bai, Wang Peng, Mengli Zheng, Yilei Yang, Bin Cheng, Zhou Luan
Summary: In pancreatic cancer, eIF4A1 downregulates E-cadherin expression through the c-MYC/miR-9 axis, promoting EMT and metastasis. Intervention on eIF4A1 and c-MYC can reduce the EMT and metastasis capabilities of pancreatic cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Virology
Yung-Ju Yeh, Ching-Ping Tseng, Sheng-Da Hsu, His -Yuan Huang, Michael M. C. Lai, Hsien-Da Huang, Ju-Chien Cheng
Summary: MicroRNA let-7b is induced by HCV infection and directly targets the HCV genome to regulate HCV replication. Through targeting negative regulators of IFN signaling, let-7b enhances IFN expression and signaling to limit HCV replication in the early stage of infection. This study sheds new insight into the role of let-7b in combating HCV infection and understanding the initial defense mechanisms against RNA viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Cell Biology
Si-Yang Wang, Yue Xu, Quan Hong, Xiang-Mei Chen, Guang-Yan Cai
Summary: This study demonstrated that aged mice are more susceptible to AKI injury and identified an important role for the upregulation of the senescence-associated DNA damage/p53 pathway in this susceptibility. MSC treatment can reduce the degree of DNA damage and apoptosis. Furthermore, downregulation of let-7b-5p may lead to increased renal AKI susceptibility, and the presence of let-7b-5p in MSC-derived Exos can alleviate tubular epithelial cell apoptosis by inhibiting p53.
CELL AND TISSUE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marzieh Jamalidoust, Maryam Shafaati, Mehdi Kalani, Maryam Zare, Mazyar Ziyeayan
Summary: The study demonstrates the inhibitory effect of let-7b on HCV replication by promoting apoptosis and reducing HCV-RNA load. Therefore, let-7b may serve as a potential antiviral therapy target.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Oncology
Zhuohui Lin, Mariia Radaeva, Artem Cherkasov, Xuesen Dong
Summary: This study discusses the role of the RNA-binding protein Lin28 in regulating cancer cell stemness and promoting tumor progression. Lin28 controls the expression of oncogenes by acting on various types of RNAs in cancer cells. The study also highlights the importance of understanding the critical drivers and molecular mechanisms underlying therapy resistance in tumors. The development of Lin28 inhibitors targeting CSCs is also discussed.
Article
Medicine, Research & Experimental
Yun Liu, Jun Zhang, Fang Cao, Xiaobao Dong, Jie Li, Yanna Cao, Zhanglin Li, Yan Guo, Jie Yan, Yuanyuan Liu, Qiang Zhao
Summary: This study reveals that the upregulation of lncRNA ADAMTS9-AS2 inhibits proliferation and metastasis in neuroblastoma by inhibiting LIN28B's association with pri-let-7 miRNA and subsequently affecting the activity of oncogene MYCN. The differential expression of ADAMTS9-AS2 in neuroblastoma cells is also associated with N6-methyladenosine methylation.
Article
Chemistry, Medicinal
Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang
Summary: Emodin can attenuate pulmonary fibrosis and epithelial-mesenchymal transition (EMT) by regulating the c-MYC/miR-182-5p/ZEB2 axis, providing evidence for the application of Emodin in the treatment of pulmonary fibrosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Ying-Ting Wu, Si-Yu Ma, Wen-Qin Sun, Wei-Wei Shen, Hui-Ting Zhu, Qin Zhang, Hui-Fen Chen
Summary: The study found that TRIM65 is up-regulated in ectopic endometrial tissues and EMS cells, positively correlated with p-ERK1/2, C-myc, MMP-2, and integrin β1 levels. TRIM65 promotes proliferation and invasion of EMS cells through the ERK1/2/C-myc pathway via DUSP6 ubiquitination. The feedback loop between TRIM65 and the ERK1/2/C-myc signaling pathway may be a potential therapeutic target for endometriosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Xin Liu, Hongjuan He, Fengwei Zhang, Xin Hu, Fanqi Bi, Kai Li, Haoran Yu, Yue Zhao, Xiangqi Teng, Jiaqi Li, Lihong Wang, Yan Zhang, Qiong Wu
Summary: Exploring the epigenetic regulation mechanism of colorectal cancer from the perspective of N6-methyladenosine modification may provide a new target for tumor therapy. The study found that the gene expression of METTL3 was significantly upregulated in CRC, promoting the methylation of EphA2 and VEGFA, which were prevented from mRNA degradation by the m6A readers IGF2BP2/3. EphA2 and VEGFA could promote vasculogenic mimicry formation in colorectal cancer through different IGF2BP-dependent mechanisms.
CELL DEATH & DISEASE
(2022)
Article
Anatomy & Morphology
Sourangshu Chakraborti, Aparajita Karmakar, Riana Guha, Christopher Ngan, Raunak Kumar Das, Noel Whitaker
Summary: This study investigates the induction of EMT by HPV16 in the C33A cell line. Immunofluorescence and RT-PCR were used to examine the expression of 8-catenin, EMT-TFs, and c-myc in HPV16 E6/E7 oncogene transfected and nontransfected C33A cells. ImageJ and Python programming were utilized for image analysis. The results show that HPV16 E6/E7 oncogene can induce EMT based on the increased expression of 8-catenin, c-myc, and EMT-TFs.
Article
Cell Biology
Aristeidis E. Boukouris, Yongneng Zhang, Bruno Saleme, Adam Kinnaird, Yuan Yuan Zhao, Yongsheng Liu, Sotirios D. Zervopoulos, Subhash K. Das, Rohan D. Mittal, Alois Haromy, Maria Areli Lorenzana-Carrillo, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Gopinath Sutendra, Evangelos D. Michelakis
Summary: Metabolic stress can induce the expression of CRMP2A in cancer cells, inhibiting epithelial-to-mesenchymal transition (EMT) and stemness. Loss of CRMP2A leads to microtubule remodeling, increased glutamine utilization, and enhanced EMT/stemness. The expression of CRMP2A is decreased in metastatic tumors compared to primary tumors in prostate cancer patients.
Article
Cell Biology
Yu Tian, Bo Tang, Chengye Wang, Yan Wang, Jiakai Mao, Yifan Yao, Zhenming Gao, Rui Liang, Mingliang Ye, Shijie Cai, Liming Wang
Summary: The study reveals that in intrahepatic cholangiocarcinoma (iCCA), high expression of USP22 is associated with malignant invasion and poorer overall survival, can increase cell proliferation and migration, and induce epithelial-to-mesenchymal transition (EMT).
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Lan Zhao, Jianshuo Wang, Pengzhen Wang, Zhanyu Deng, Jin Cui, Weiguang Huang, Shaoheng Zhang
Summary: Cardiac-resident mesenchymal stem cells (cMSCs) can undergo mesenchymal-to-endothelial transition (MEndoT) with the cooperation of Oct4 and c-Myc, promoting angiogenesis and enhancing myocardial repair.
STEM CELL RESEARCH & THERAPY
(2022)